Postgraduate research
Cardiovascular Sciences
Biomarkers
- Diagnostics and monitoring in Emergency Care
- The role of biological ageing in coronary artery disease
- Investigating the biological mechanism by which telomere length influences cardiovascular risk
- How modulating telomere length affects cellular physiology and response to pro-atherogenic stress
- Investigating the relationship between telomere length and other cardiovascular phenotypes and risk factors
- Genetic regulation of telomere length in humans
- Identification of additional genetic determinants of LTL
- Identification of the functional SNP(s) within each locus and the mechanism by which they impact on gene/protein function and LTL regulation.
- Investigating the biological mechanism by which the Chr2 (ACYP2) and Chr19 (ZNF) influence LTL
- Epigenetic and gene expression changes associated with changes in LTL
- Molecular and cellular mechanisms of cardiovascular ageing
- Oxidative DNA damage and repair in humans
- Mitochondria and cellular oxidative stress
- Signal transductin associated with the following receptor systems as relevant to pain, sepsis and cardiovascular disease
- Classical and non classical (Nociceptin) Opioid receptors
- Vanilloid (TRPV1) receptors
- Urotensin II receptors
- Inflammatory Organ Injury Post Cardiac Surgery
- Blood Management
- Study of the genetic variation underlying cardiovascular disease and related traits via:
- Genome wide association studies
- Genome wide transcriptome analysis
- Mendelian randomisation
- Collapsing statistics
- Runs of homozygosity
- Pathway analysis
- Genome wide Meta-analyses of genetic data
- Whole genome imputation
- Gene-gene interactions
- Work on sex-chromosomes including Y-haplogroups
- Genome wide methylation data
- Autonomic modulation of Electrical Restitution and Ventricular Fibrillation initiation
- Nitric oxide in mediating vagal protection of the heart against VF
- Non-invasive markers of ventricular arrhythmia risk stratification
- Atrial fibrillation - spectral characteristics and catheter ablation
- Electromechanical refinement of multi-site cardiac pacing
- Studies on the role of cardiovascular peptides in heart disease
- The use of hormonal markers for diagnosis and prognosis in heart disease and to determine therapeutic response to various drug treatments
- Use of proteomic technologies in biomarker discovery
- Action potential duration restitution and its role in the genesis of ventricular arrhythmia and sudden cardiac death.
- Heart failure: in particular optimising cardiac resynchronisation therapy.
- Physiological measurement and modelling
- Cerebral haemodynamics, particularly the regulation of cerebral blood flow
- Cardiovascular system regulation, particularly the short-term regulation of arterial blood pressure
- Natriuretic peptides and other biomarkers in heart failure
- Epidemiology of heart failure
- Novel pharmacological therapies in heart failure
- Data linkage as a research tool
- Multicentre trials in heart failure
- Epidemiology and management of acute coronary artery disease
- Aortic diseases (mechanisms/epidemiology/diagnosis/treatment)
- Cardiovascular biomarkers (proteins/metabolites)
- Gut microbiome in cardiovascular disease
- Obstetrics
- Metabolism - gestational diabetes mellitus
- Cardiovascular - preeclampsia
- Reproductive sciences
- Data research
Genomics
- Abdominal aortic aneurysms
- Genomics
- AAA growth
- AAA screening
- Data linkage
- How receptors work: mechanistic, functional and structural biology of receptors
- Directed evolution for creating new proteins and understanding protein function and structure
- Cardiovascular protective signalling
- The role of biological ageing in coronary artery disease
- Investigating the biological mechanism by which telomere length influences cardiovascular risk
- How modulating telomere length affects cellular physiology and response to pro-atherogenic stress
- Investigating the relationship between telomere length and other cardiovascular phenotypes and risk factors
- Genetic regulation of telomere length in humans
- Identification of additional genetic determinants of LTL
- Identification of the functional SNP(s) within each locus and the mechanism by which they impact on gene/protein function and LTL regulation.
- Investigating the biological mechanism by which the Chr2 (ACYP2) and Chr19 (ZNF) influence LTL
- Epigenetic and gene expression changes associated with changes in LTL
- Study of the genetic variation underlying cardiovascular disease and related traits via:
- Genome wide association studies
- Genome wide transcriptome analysis
- Mendelian randomisation
- Collapsing statistics
- Runs of homozygosity
- Pathway analysis
- Genome wide Meta-analyses of genetic data
- Whole genome imputation
- Gene-gene interactions
- Work on sex-chromosomes including Y-haplogroups
- Genome wide methylation data
- Cardiovascular genetics
- Role of biological ageing in coronary heart disease
- Obstetrics
- Metabolism - Gestational Diabetes Mellitus
- Cardiovascular - Preeclampsia
- Reproductive Sciences
- Data research
- Understanding the molecular and cellular mechanisms of genetic variants associated with coronary artery disease
Imaging
Dr Ranjit Arnold
- The role of cardiac MRI in the evaluation of patients with suspected coronary heart disease
- Investigation and management of coronary microvascular disease
- Assessment and therapeutic targeting of impaired myocardial perfusion in heart failure
- Artificial intelligence in the evaluation of cardiac MRI images
- Pathophysiology of COVID-related organ injury
- Integrated physical-mental health for older people
- Physical activity interventions for older people with severe mental illness
- Service design and delivery
- Cerebral haemodynamics and vascular mechanisms in ageing, cognitive and mental health disorders for older people
- Cerebral blood flow and autoregulation in neurodegenerative diseases, including idiopathic Parkinson’s disease, mild cognitive impairment and dementia syndromes
- Parkinson’s disease
- Haemodynamic mechanisms of post-operative cognitive dysfunction
- Predictors of decline in mild cognitive impairment
- Post-stroke dementia/cognitive decline
- Clinical trials
- The role of cardiac MRI in the management of patients with suspected cardiac disease
- Detection and quantification of subclinical myocardial dysfunction (using novel strain measurement)
- Aortic stenosis- determinants of symptoms and timing of surgery
- Diabetic cardiomyopathy
- Assessment of novel treatments for STEMI and cardiovascular dysfunction/heart failure
- Pathophysiology, prognosis and treatment of HFpEF
- Investigation and management of patients with suspected angina
- Technical studies in cerebrovascular physiology (particularly acute intracerebral haemorrhage)
- Multi-modality research
- Delivering technically excellent and innovative translational programmes of research with the potential to deliver significant improvements in stroke care, in reasonable time frames
- Severe stroke syndromes and prognostication including pre-hospital assessment(s)
- Studies on the role of cardiovascular peptides in heart disease
- The use of hormonal markers for diagnosis and prognosis in heart disease and to determine therapeutic response to various drug treatments
- Use of proteomic technologies in biomarker discovery
- Physiological measurement and modelling
- Cerebral haemodynamics, particularly the regulation of cerebral blood flow
- Cardiovascular system regulation, particularly the short-term regulation of arterial blood pressure
- Blood Pressure and Acute Stroke
- Autonomic Dysfunction and Acute Stroke
- Cerebrovascular Autoregulation and Acute Stroke
- Multi-centre Stroke Trials
- Predicting Disability in an Ageing Population
- The role of cardiac MRI in increasing our understanding of the pathophysiology of myocardial remodelling response to valve disease.
- The role of imaging and blood biomarkers in the risk stratification of patients with aortic stenosis.
- Using novel imaging techniques (4D Flow) to understand haemodynamics within the heart and the aorta in patients with bicuspid and tri-leaflet aortic valve disease.
- Using novel contrast agents, such as manganese and USPIO.
- Detection and quantification of subclinical myocardial dysfunction (using novel strain measurement)
- Aortic stenosis- determinants of symptoms and timing of surgery.
- Health inequalities in diagnosis and management of patients with valve disease.
- Obstetrics
- Metabolism - Gestational Diabetes Mellitus
- Cardiovascular - Preeclampsia
- Reproductive Sciences
- Data research
- Development of novel non-invasive monitoring modalities in acute illness
- Integration of non-invasive monitoring for early diagnosis in acute illness
Intervention
- Rare coronary artery diseases:
- Spontaneous coronary artery dissection (SCAD) and Coronary aneurysms and estasia (CAE)
- Cardio-oncology
- National data linkage studies
- Novel medical devices
- Coronary optical coherence tomography (including as part of minimal invasive autopsy)
- Endocarditis
- Integrated physical-mental health for older people
- Physical activity interventions for older people with severe mental illness
- Service design and delivery
- Cerebral haemodynamics and vascular mechanisms in ageing, cognitive and mental health disorders for older people
- Abdominal aortic aneurysms
- Genomics
- AAA growth
- AAA screening
- Data linkage
- How receptors work: mechanistic, functional and structural biology of receptors
- Directed evolution for creating new proteins and understanding protein function and structure
- Cardiovascular protective signalling
- Cardiovascular electrophysiology: Ventricular Fibrillation and Sudden Cardiac Death
- Autonomic modulation of Electrical Restitution and Ventricular Fibrillation initiation
- Myocardial electrical heterogeneity and cardiotopic innervation of the sympathetic nerves
- Experimental models of Heart Failure
- Coagulation following injury
- Multi-centre trials in emergency care
- Predictive modeling of outcome following injury
- Cerebral blood flow and autoregulation in neurodegenerative diseases, including idiopathic Parkinson’s disease, mild cognitive impairment and dementia syndromes
- Parkinson’s disease
- Haemodynamic mechanisms of post-operative cognitive dysfunction
- Predictors of decline in mild cognitive impairment
- Post-stroke dementia/cognitive decline
- Clinical trials
- The role of cardiac MRI in the management of patients with suspected cardiac disease
- Detection and quantification of subclinical myocardial dysfunction (using novel strain measurement)
- Potential (lifestyle and pharmacologic) therapies for diabetic cardiomyopathy
- Assessment of novel treatments for STEMI and cardiovascular dysfunction/heart failure
- Pathophysiology, prognosis and treatment of HFpEF
- Investigation and management of patients with suspected angina
- Technical studies in cerebrovascular physiology (particularly acute intracerebral haemorrhage)
- Multi-modality research
- Delivering technically excellent and innovative translational programmes of research with the potential to deliver significant improvements in stroke care, in reasonable time frames
- Severe stroke syndromes and prognostication including pre-hospital assessment(s)
- Inflammatory Organ Injury Post Cardiac Surgery
- Blood Management
Professor Ross Naylor
- Reducing the risks of carotid surgery
- Factors mediating acute changes in carotid plaque morphology
- Aortic graft infection management
- Antiplatelet function during carotid surgery
- Autonomic modulation of Electrical Restitution and Ventricular Fibrillation initiation
- Nitric oxide in mediating vagal protection of the heart against VF
- Non-invasive markers of ventricular arrhythmia risk stratification
- Atrial fibrillation - spectral characteristics and catheter ablation
- Electromechanical refinement of multi-site cardiac pacing
- Blood Pressure and Acute Stroke
- Autonomic Dysfunction and Acute Stroke
- Cerebrovascular Autoregulation and Acute Stroke
- Multi-centre Stroke Trials
- Predicting Disability in an Ageing Population
- Acute and chronic kidney injury after vascular surgery or endovascular intervention (clinical trials and a national cohort study)
- Cardiovascular risk reduction studies in patients with aneurysmal disease
- Qualitative research relating to aneurysm screening and vascular disease
- Literature synthesis in vascular diseases
- Pathogenesis and outcome of abdominal aortic aneurysms
- Obstetrics
- Metabolism - Gestational Diabetes Mellitus
- Cardiovascular - Preeclampsia
- Reproductive Sciences
- Data research
- Cardiac arrhythmia and implantable cardiac rhythm management devices (pacemakers and defibrillators)
- Resuscitation science
- Cardiovascular clinical trials
- Aviation medicine and cardiovascular aspects of fitness to fly
- Inflammatory Organ Injury Post Cardiac Surgery
- Endothelial dysfunction post cardiac surgery and miRNA regulation
- Blood Management
Nephrology
- Genetics and epigenetics of IgA Nephropathy
- Role of the innate immune system in IgA Nephropathy
- Novel therapies in IgA Nephropathy
- IgA structure and function
- Lymphocyte trafficking and IgA Nephropathy
- Role of complement in glomerular injury in IgA Nephropathy
- Cellular Mechanisms and novel interventions in proteinuric progressive renal disease and diabetic nephropathy
- Complement pathways in tubulointerstitial disease
- Study of microparticles as novel biomarkers of cardiovascular disease in uraemia
- Community studies of chronic kidney disease and acute kidney injury risk factors, and implementation of novel management strategies
- Mechanisms of left ventricular hypertrophy, inflammation and fibrosis in CKD
- Interventions to improve cardiovascular outcomes in dialysis patients
- Novel biomarkers for the assessment of cardiovascular risk in patients with CKD
Dr Emma Watson
- Therapeutic use of exercise in CKD
- Molecular mechanisms of muscle wasting in human CKD
- Understanding whether clinical practice guideline recommendations meet the needs of people living with chronic kidney disease
- Investigate the effectiveness of treatments of sleep apnoea for people living with chronic kidney disease
- Using novel evidence synthesis techniques to understand the effectiveness of treatments for people living with chronic kidney disease
Protection
- How receptors work: mechanistic, functional and structural biology of receptors
- Directed evolution for creating new proteins and understanding protein function and structure
- Cardiovascular protective signalling
- Molecular and cellular mechanisms of cardiovascular ageing
- Oxidative DNA damage and repair in humans
- Mitochondria and cellular oxidative stress
Professor Ross Naylor
- Reducing the risks of carotid surgery
- Factors mediating acute changes in carotid plaque morphology
- Prevention and treatment of Aortic graft infection
- Antiplatelet function during carotid surgery
- Action potential duration restitution and its role in the genesis of ventricular arrhythmia and sudden cardiac death.
- Heart failure: in particular optimising cardiac resynchronisation therapy.
- Natriuretic peptides and other biomarkers in heart failure
- Epidemiology of heart failure
- Novel pharmacological therapies in heart failure
- Data linkage as a research tool
- Multicentre trials in heart failure
- Epidemiology and management of acute coronary artery disease
- Obstetrics
- Metabolism - Gestational Diabetes Mellitus
- Cardiovascular - Preeclampsia
- Reproductive Sciences
- Data research
- Cardiac arrhythmia and implantable cardiac rhythm management devices (pacemakers and defibrillators)
- Resuscitation science
- Cardiovascular clinical trials
- Aviation medicine and cardiovascular aspects of fitness to fly