Professor Gavin Murphy

BHF Chair of Cardiac Surgery/Consultant Cardiac Surgeon

School/Department: Life Sciences, College of

Telephone: +44 (0)116 256 3054

Email: gjm19@le.ac.uk

Address: Department of Cardiovascular Sciences University of Leicester Glenfield Hospital Leicester LE3 9QP

Profile

Gavin Murphy is an academic cardiac surgeon at the University of Leicester. He graduated in Medicine at the University of Bristol and went on to obtain his MD from the University of Leicester. He trained in Cardiothoracic Surgery in the South West of England and in Lausanne Switzerland, and was appointed as a Walport Consultant Senior Lecturer in Cardiac Surgery at the University of Bristol in 2007. He was appointed to the British Heart Foundation Chair of Cardiac Surgery at the University of Leicester in 2012.

He is the Director of the Leicester Clinical Trials Unit (LCTU) and Cardiothoracic Surgery Lead for the Royal College of Surgeons of England Clinical Trials Initiative.

Research

Gavin Murphy's research interests include diseases affecting the thoracic aorta, blood management (TiTRE2 trial, NEJM 2015), and the prevention of perioperative organ injury. His research has been awarded the Ronald Edwards Medal and the John Parker Medal by the Society for Cardiothoracic Surgery in Great Britain and Ireland, and the Hans G Borst Award for Thoracic Aortic Surgery, by the European Association of Cardiothoracic Surgeons.

Publications

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Murphy GJ, et al. Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials. Southampton (UK): NIHR Journals Library; Programme Grants for Applied Research 5.14. 2017 Sep.

Mariscalco G, et al. Body mass index and mortality among adults undergoing cardiac surgery: A nationwide study with a systematic review and meta-analysis. Circulation. 2017 Feb 28;135(9):850-863.

Bottle A, et al. Unwarranted variation in the quality of care for patients with diseases of the thoracic aorta. J Am Heart Assoc. 2017 Mar 14;6(3). pii: e004913.

Reeves BC, Pike K, Rogers CA, Brierley RCM, Stokes EA, Wordsworth S, Nash RL, Miles A, Mumford AD, Cohen A, Angelini GD, Murphy GJ, for the TITRe2 investigators. A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery (TITRe2) HTA Journal June 2016.

Patel NN, Avlonitis V, Jones H, Sterne JAC, Reeves BC, Murphy GJ. Indications for red cell transfusion in cardiac surgery: A systematic review and meta-analysis of randomised controlled trials and observational studies. Lancet Haematol. 2015 Dec;2(12):e543-53.

Murphy GJ, Pike K, Rogers CA, Wordsworth S, Stokes EA, Angelini GD, Reeves BC on behalf of TITRe2 Investigators. Liberal or restrictive transfusion after cardiac surgery: TITRe2 randomized trial. New England Journal of Medicine 2015 Mar 12;372(11):997-1008.

Birnie K, Verheyden V, Pagano D, Bhabra B, Tilling K, Sterne JAS, Murphy GJ. Predictive models for Kidney Disease: Improving Global Outcomes (KDIGO) Defined Acute Kidney Injury in UK Cardiac Surgery. Critical Care 2014;18:606

Rogers CA, Pike K, Angelini GD, Reeves BC, Glauber M, Ferrarini M, Murphy GJ. An open randomized controlled trial of median sternotomy versus anterolateral left thoracotomy on morbidity and health care resource use in patients having off-pump coronary artery bypass surgery: the Sternotomy Versus Thoracotomy (STET) trial. J Thorac Cardiovasc Surg. 2013 Aug;146(2):306-16.e1-9.

Patel NN, Lin H, Jones C, Walkden G, Ray P, Sleeman PA, Angelini GD, Murphy GJ. Interactions of cardiopulmonary bypass and erythrocyte transfusion in the pathogenesis of pulmonary dysfunction in Swine. Anesthesiology. 2013 Aug;119(2):365-78

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, Murphy GJ. Reversal of anaemia with allogenic RBC transfusion prevents post cardiopulmonary bypass acute kidney injury in swine. Am J Physiol Renal Physiol 2011;301(3):F605-14.

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, Murphy GJ. Phosphodiesterase Type 5 inhibition prevents post cardiopulmonary bypass acute kidney injury in swine. Annals of Thoracic Surgery 2011;92(6):2168-76.

Patel NN, Rogers CS, Angelini GD, Murphy GJ. Pharmacological therapies for the prevention of acute kidney injury following cardiac surgery: A systematic review. Heart Failure Reviews 2011;16(6):553-67.

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, George SJ, Murphy GJ. Prevention of post cardiopulmonary bypass acute kidney injury by endothelin-A receptor blockade. Critical Care Medicine 2011;39:793-802.

Murphy GJ, Reeves BC, Rogers CA, Rizvi SIA, Culliford L, Angelini GD. Increased mortality, post-operative morbidity and cost following red blood cell transfusion in patients having cardiac surgery. Circulation 2007;116:2544-52.

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Press and media

For media enquires, please contact Sue Page.

Activities

Professor Murphy was appointed Director of the Leicester Clinical Trials Unit in 2017.

Current committee memberships

  • Chairman, Academic and Research Committee, Society for Cardiothoracic Surgery in UK and Ireland (SCTS) 2015-2021
  • Member SCTS Executive 2015-
  • Associate Editor Heart 2013-
  • Associate Editor Cochrane Heart Group 2014-

Awards

Ronald Edwards Medal and the John Parker Medal by the Society for Cardiothoracic Surgery in Great Britain and Ireland.

The Hans G Borst Award for Thoracic Aortic Surgery, by the European Association of Cardiothoracic Surgeons.

Qualifications

  • BSc in Physiology, Bristol, 1991
  • MBChB, Bristol, 1994
  • FRCS (Eng), 1998
  • MD, Leicester, 2003
  • FRCS (C.Th), 2005
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