Structure determination of protein and protein nucleic acid complexes allows us to understand the mechanisms of macromolecular complexes machines that carry out the processes of life. Structural biology can also provide detailed insights into strategies to develop small and medium-sized molecules that can alter protein functions and serve as effective therapeutics.
Our researchers in the Institute for Structural and Chemical Biology are increasingly working together to improve our understanding of the workings of life. Our researchers use chemistry to develop probes and tools to explore biological systems – providing a ‘chemical view’ of human biology. By exploiting this chemistry, we are able to manipulate macromolecular function and activity. This is important for both drug development and the development of research tools.