Institute for Structural and Chemical Biology


All our research is driven by people. Our academics lead research groups with postdocs, PhD students and technical staff, often in collaboration with each other and other colleagues. Our facility managers provide technical expertise and are outstanding scientists in their own right.

See our Management and Advisory Board

Institute Director

John SchwabeProfessor John Schwabe

  • Professor of Structural Biology
  • Structural Biology: NMR Spectroscopy and X-ray Crystallography
  • Molecular mechanisms of the regulation of gene expression
  • Nuclear receptors and their role in metabolism, development and disease
Learn more about Professor John Schwabe

Institute Deputy Director

Andrew HudsonProfessor Andrew Hudson

  • Professor of Biophysical Chemistry
  • Specialises in applying optical methods including optical tweezing molecular spectroscopy and microscopy (and combinations of these) to address problems at the life science interface
Learn more about Professor Andrew Hudson

Institute Manager


Philip Ash

Philip AshResearch group

  • Metalloenzyme mechanism with sub-turnover frequency time resolution
Learn more about Philip Ash

Steve Bull

portraitSynthetic methodologies for functional molecules with interesting physical and biological properties


Learn more about Steve Bull

Amanda Chaplin

portrait Amanda ChaplinResearch group

  • Structural architecture of DNA repair machinery
Learn more about Amanda Chaplin

Cyril Dominguez

Research groupprofile pi Cyril Dominguez

  • Structure and function of RNA processing complexes
Learn more about Cyril Dominguez

Richard Doveston

Richard DovestonResearch group

  • Stabilising protein-protein interactions
Learn more about Richard Doveston

Ian Eperon

Ian Eperon profileResearch group

  • RNA splicing: from single-molecules to therapy
Learn more about Ian Eperon

Joanna Fox

Joanna FoxResearch group

  • Regulation and molecular architecture of apoptotic protein complexes
Learn more about Joanna Fox

Bibek Gooptu

Bibek GooptuResearch group

  • Conformational mechanisms of lung and liver disease
Learn more about Bibek Gooptu

Gareth Hall

Gareth HallResearch group

  • Structure-based drug discovery

James Hodgkinson

portrait james hodgkinsonResearch group

  • Synthetic organic chemistry and chemical biology
Learn more about James Hodgkinson

Richard Hopkinson

Richard HopkinsonResearch group

  • Understanding the functional role of formaldehyde in health and disease
Learn more about Richard Hopkinson

Andrew Hudson

Andrew HudsonResearch group

  • Biospectroscopy and imaging
Learn more about Andrew Hudson

Abhinav Koyamangalath Vadakkepat

Research Group: Structural biology of cell wall integrated nanomachines

Learn more about Abhinav Koyamangalath Vadakkepat

Hanna Kwon

Hanna KwonResearch group

  • Metalloenzyme mechanisms
Learn more about Hanna Kwon

Yolanda Markaki

portrait YolandaResearch group

  • Developmental epigenetics and nuclear architecture

Learn more about Yolanda Markaki

Peter Moody

portrait Peter MoodyResearch group

  • Enzyme structure and function
Learn more about Peter Moody

Helen O'Hare

Helen o'HareResearch group

  • Molecular mechanisms of sensory perception and metabolic regulation in bacteria
Learn more about Helen O'Hare

Daniel Panne

Daniel PanneResearch group

  • Structural biology of signal transduction and epigenetic gene regulation
Learn more about Daniel Panne

Patricia Rodriguez Macia

portrait of Patricia Rodriguez MacaiaBiocatalysis to learn from and mimic nature at the intersection of chemistry, biology and materials science


Learn more about Patricia Rodriguez Macia

Thomas Schalch

Thomas SchlachResearch group

  • Chromatin structure and function

Learn more about Thomas Schalch

Ralf Schmid

portrait Ralf SchmidResearch group

  • Molecular modelling and bioinformatics
Learn more about Ralf Schmid

John Schwabe

John SchwabeResearch group

  • Structural biology of transcriptional repression complexes
Learn more about John Schwabe

Rama Suntharalingam

Research groupportrait Rama Suntharalingam

  • Metallopharmaceuticals for the treatment of cancer
Learn more about Rama Suntharalingam

Geerten W Vuister

Geerten VuisterResearch group

  • Structural biology of Ca2+-transport regulation complexes

Learn more about Geerten W Vuister

Russell Wallis

Research groupportrait professor Russell Wallis

  • Structural biology of complement activation
Learn more about Russell Wallis

Facility managers

Dr Jaswir Basran

Jaswir BasranBiophysical characterisation

Learn more about Jaswir Basran

Dr Fred Muskett

Dr Emma Hesketh

Dr TJ Ragan

TJ RaganResearch Computing Officer

TJ is the Scientific Computation Officer at the Institute of Structural and Chemical Biology.

Previous to this role he was a postdoctoral scientist at Leicester University and before that at NIMR in Mill Hill. His scientific interests are protein NMR protein structure calculations and single particle cryo-EM.

Honorary members

Some of our past principal investigators remain affiliated to the Institute for Structural and Chemical Biology as honorary members.

Ivan Campeotto

Research group

  • Structural studies of key regulators of malaria and trypanosomal infections
Learn more about Ivan Campeotto

Mark Carr

portrait of Professor Mark CarrResearch group

  • Structure-based drug discovery
Learn more about Mark Carr

Alfredo De Biasio

Research group

  • Molecular architecture and function of DNA replication and repair machines
Learn more about Alfredo De Biasio

Pietro Roversi

Research group

  • ERQC/ERAD modulation for broad-spectrum glycoprotein secretion-rescue in rare disease
Learn more about Pietro Roversi

Postdoctoral researchers

Beatriz Romartinez Alonso

Beatriz Romartinez Alonso is part of the group of John Schwabe.

Find out more about Beatriz Romartinez Alonso

Robert Turnbull

Robert Turnbull is part of the group of John Schwabe.

Find out more about Robert Turnbull

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