Dr Chris Millard

I work in the Schwabe group to understand the structure and function of Histone Deacetylase complexes. My current project is to use cryo-electron microscopy to study one of the six histone-containing complexes as well as develop an understanding of its function within the cell.

Turnbull, R., Fairall, L., Saleh, A., Kesall, E., Morris, K., Ragan, T., Savva, C., Chandru, A., Millard, C., Makarvova, O., Smith, C., Rosemann, A., Fry, A., Cowley, S., Schwabe, J.W.R. (2020) The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nature Communications 11, 3252.

Millard, C.J., Fairall, L., Ragan, T.J., Savva, C.G. and Schwabe, J.W.R. (2020) The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Research 48, 12972.

Wang, Z.A., Millard, C.J., Lin, C-L., Gurnett, J., Wu, M., Lee, K., Fairall, L., *Schwabe, J.W.R., *Cole, P.A. (2020) Diverse Nucleosome Site-Selectivity Among Histone Deacetylase Complexes. eLife 9, e57663. *Co-corresponding authors

Smalley, J., Adams, G., Millard, C., Song, Y., *Schwabe, J.W.R., *Cowley, S., *Hodgkinson, J. (2020) PROTAC mediated degradation of Class-I histone deacetylase enzymes in corepressor complexes. Chemical Communications doi: 10.1039/d0cc01485k. *Co-corresponding authors