Dr James Hodgkinson
Associate Professor of Chemistry and Chemical Biology
Profile
Research
Publications
(0)
Selected publications:
- Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells, J.P. Smalley, I.M. Baker, W.A. Pytel, L.Y. Lin, K.J. Bowmann, J.W.R. Schwabe, S.M. Cowley, J.T. Hodgkinson, J. Med. Chem. 2022, 65, 5642-5659.
- PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes, J. P. Smalley, G. E. Adams, C. J. Millard, Y. Song, J. K. S. Norris, J. W. R. Schwabe, S. M. Cowley, J. T. Hodgkinson, Chem. Commun. 2020, 56, 4476-4479.
- HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions, G.M. Williams, V. Paschalis, J. Ortega, F. W. Muskett, J.T. Hodgkinson, G. Li, J.W.R. Schwabe, R.S. Lahue. Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 23597-23605.
- Bifunctional HDAC Therapeutics: One Drug to Rule Them All? J.P. Smalley, S.M. Cowley, J.T. Hodgkinson, Molecules, 2020, 25, 4394.
- Siderophore-Antibiotic Conjugate Design - New Drugs for Bad Bugs? K. H. Negash, J. K. S. Norris, J. T. Hodgkinson, Molecules, 2019, 24, 3314.
- A new pseudomonas quinolone signal (PQS) binding partner: MexG, J. T. Hodgkinson, J. Gross, Y.R. Baker, D.R. Spring, M. Welch, Chem. Sci. 2016, 7, 2553-2562.
For full publication list see: https://orcid.org/0000-0001-9978-7322
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Supervision
- Chemical Biology
- Medicinal Chemistry
- Synthetic Organic Chemistry,
- Drug Discovery
Please contact me directly for enquires regarding opportunities for PhD studentships or postdoctoral positions.
Teaching
Press and media
Activities
Conferences
Invited speaker - SCI Conference: Targeting protein degradation 3 – from discovery to the clinic, Society of Chemical Industry, London, 8th and 9th June 2022
Invited speaker - University of Nottingham, 11th May, 2022
Invited speaker - University of York, 19th Nov, 2021
Invited speaker - Young Chemists 2021, Imperial College London (remote), 23.04.2021
Invited speaker - RSC Chemical Biology and Bio-Organic Group (CBBG) Forum, 10th Jan 2020
Invited speaker - Polymicrobial Meeting, Cambridge, 11th Dec 2019
Invited speaker - Gregynog Synthesis Workshop, Wales, 13th Sept 2018
Poster presentation - Astbury Conversation, Leeds, 16th April 2018
Invited speaker - RSC East Midlands organic section meeting, Leicester, 5th April 2017