People

Dr Thomas Schalch

Associate Professor

School/Department: Molecular Cell Biology Department of

Telephone: +44 (0)116 229 7120

Email: ts332@leicester.ac.uk

Profile

"Biography since 2018 Associate Professor University of Leicester 2012-2018 SNF Professor University of Geneva 2010-2012 Research Investigator Cold Spring Harbor Laboratory 2006-2010 Postdoctoral Fellow Cold Spring Harbor Laboratory 2004-2006 Postdoctoral Fellow ETH Zurich Education 2004 Ph.D. in Natural Sciences ETH Zurich 1999 Diploma in Biology ETH Zurich Honors 2012-2018 Swiss National Science Foundation Professorship 2007-2010 Human Frontiers in Science Program Fellowship 2006-2007 EMBO Post-doctoral Fellowship 2005ETH Award / Medal for exceptional PhD thesis "

Research

"We focus on discovering structural and biochemical principles that operate to organize and programme genomes is the major goal of research in my laboratory. Many of these processes are tightly linked to cancer and are of great interest for the development of therapeutic interventions. The following projects are currently actively pursued in my laboratory: • The structure of the chromatin fibre in the cell nucleus and its relationship to gene regulation remains poorly understood. (BBSRC grant BB/R016275/1). • Ubiquitination is not only critical for protein degradation but also for chromatin signalling where it orchestrates downstream histone modifications on transcribed genes. Our work on the histone H2B ubiquitin ligase complex aims to reveal the mechanism driving the protection of active genes by H2B ubiquitination from heterochromatin invasion. (BBSRC grant BB/S018549/1). • Our recent work on the regulation of histone H3 methyltransferase Clr4 established that ubiquitination also controls heterochromatin formation. We are very keen to investigate the molecular mechanisms that control this key enzyme. "

Publications

(0)

Stirpe A. Guidotti N. Northall S. Kilic S. Hainard A. Vadas O. Fierz B. Schalch T. (preprint). SUV39 SET domains mediate crosstalk of heterochromatic histone marks. bioRxiv 2020.06.30.177071 Open Access Preprint

Leopold K. Stirpe A. and Schalch T. (2019). Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Genes & Development 33 565-577 Open Access Article

Ekundayo B. Richmond T.J. and Schalch T. (2017). Capturing structural heterogeneity in chromatin fibers. Journal of Molecular Biology 429 3031-3042. free article doi UNIGE archives Job

G. Brugger C. Xu T. Lowe B.R. Pfister Y. Qu C. Shanker S. Baños Sanz J.I. Partridge J.F. and Schalch T. (2016). SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Molecular Cell 62 207-221. Article

Kuscu C. Zaratiegui M. Kim H.S. Wah D.A. Martienssen R.A. Schalch T. and Joshua-Tor L.(2014). CRL4-like Clr4 Complex in Schizosaccharomyces Pombe Depends on an Exposed Surface of Dos1 for Heterochromatin Silencing. PNAS 111 1795-1800. Article

Schalch T. Job G. Shanker S Partridge J. F. Joshua-Tor L. (2011). The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nature Structural and Molecular Biology 18 1351-7. Article

Schalch T. Job G. Noffsinger V. J. Shanker S. Kuscu C. Joshua-Tor L. and Partridge J. F. (2009). High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Molecular Cell 34 36-46. Article

Schalch T. Duda S. Sargent D. F. and Richmond T. J. (2005). X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Nature 436 138-41. Article

Dorigo B. Schalch T. Kulangara A. Duda S. Schroeder R. R. and Richmond T. J. (2004). Nucleosome arrays reveal the two-start organization of the chromatin fiber. Science 306 1571-3. Article

Dorigo B. Schalch T. Bystricky K. and Richmond T. J. (2003). Chromatin fiber folding: requirement for the histone H4 N-terminal tail. Journal of Molecular Biology 327 85-96. Article

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Supervision

chromatin structure epigenetic mechanisms structural biology structure-function studies

Teaching

"BS2091 Biochemistry of Nucleic Acids 2019-21 BS1030 The Molecules of Life 2018-2021 BS3070 Structural Biology 2020-21 BS3X00 Third Year Projects 2019-2021 BS4006 BSc Research Project 2019-2021"

Press and media

Chromatin structure epigenetic mechanisms.
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