Professor John Schwabe’s research spans a number of interrelated areas concerned with understanding enzymes inside the cell nucleus that assemble into large complex molecular machines to regulate genes. His group has led the field in how these complexes are assembled, how they act together with other proteins to control physiology and how this mechanism is affected by disease. During the COVID-19 pandemic the team are using their structural biology expertise to investigate how SARS-CoV-2 gains entry to cells and how this may be targeted with future therapeutics.
The Leicester Institute of Structural and Chemical Biology (LISCB) houses the state-of-the-art £6 million Regional Cryo-Electron Microscopy facility, a revolutionary method to directly visualise the molecular machinery in our cells with atomic-level detail. The microscope is being operated remotely by facility Manager Dr Christos Savva who is working with academic groups and industry partners around the world to investigate how SARS-CoV-2 infects and replicates inside our cells.
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