People

Dr Jatinder Minhas

Associate Professor of Stroke Medicine / Honorary Consultant Stroke Physician

Profile

I hold the position of Associate Professor of Stroke Medicine at the University of Leicester. In addition, I am an Honorary Consultant Stroke Physician at University Hospitals of Leicester NHS Trust. As I move towards research independence I lead and collaborate on a number of clinical and physiologically focused stroke studies in addition to a number of research based leadership roles. 

Research

1) NIHR ARC PhD Studentship Matched Funding. Evaluating the feasibility of remote haemodynamic monitoring in a cohort of multi-ethnic chronic stroke patients using a novel user interface and artificial intelligence algorithms. PI.

2) NIHR East Midlands Clinical Research Network. Parkinson’s Disease in minority ethnic groups - understanding phenotypical traits to inform pathways of care in the East Midlands. Co-PI.

3) NIHR-British Association of Stroke Physicians Writing Group Funding. Clinical Frailty and its role in stroke outcomes and recovery. Co-I.

4) Medical Research Council IAX Funding. Evaluating the feasibility of assessing carbon dioxide change in stroke patients. PI.

5) Medical Research Council LD3 Confidence in Concept Grant. Brain TV confidence in concept: severe brain injury. Co-I.

6) NIHR CLAHRC Phase V Funding. Evaluating the implementation of rapid access clinics in cardiovascular disease. Co-PI.

7) Dunhill Medical Trust Clinical Research Training Fellowship. Feasibility of improving cerebral autoregulation in intracerebral haemorrhage. PI.

Publications

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*Wang X, *Minhas JS, *Moullaali TJ, Di Tanna GL, Lindley RI, Chen X, Arima H, Chen G, Delcourt C, Bath PM et al. Associations of early systolic blood pressure control and outcome after thrombolysis-eligible acute ischemic stroke: results from the ENhanced Control of Hypertension ANd Thrombolysis stroke study (ENCHANTED). Stroke. (Accepted In Press 21/06/21)

Caldwell HG, Howe CA, Hoiland RL, Carr JMJR, Chalifoux CJ, Brown CV, Patrician A, Tremblay JC, Panerai RB, Robinson TG, Minhas JS, Ainslie PN. Alterations in arterial CO2 rather than pH affect the kinetics of neurovascular coupling in humans. J Physiol. 2021 Jun 9. doi: 10.1113/JP281615. Epub ahead of print. PMID: 34107079.

Ince J, Mankoo AS, Kadicheeni M, Swienton D, Panerai RB, Robinson TG, Minhas JS. Cerebrovascular tone and resistance measures differ between healthy control and patients with acute intracerebral haemorrhage: exploratory analyses from the BREATHE-ICH study. Physiol Meas. 2021 Apr 14. doi: 10.1088/1361-6579/abf7da. Epub ahead of print. PMID: 33853052.

Minhas JS, Sammut-Powell C, Birleson E, Patel HC, Parry-Jones AR. Are do-not-resuscitate orders associated with limitations of care beyond their intended purpose in patients with acute intracerebral haemorrhage? Analysis of the ABC-ICH study. BMJ Open Qual. 2021 Feb;10(1):e001113. doi: 10.1136/bmjoq-2020-001113. PMID: 33547153.

Caldwell HG, Howe CA, Chalifoux CJ, Hoiland RL, Carr JMJR, Brown CV, Patrician A, Tremblay JC, Panerai RB, Robinson TG, Minhas JS, Ainslie PN. Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis. J Physiol. 2021 Mar;599(5):1439-1457. doi: 10.1113/JP280682. Epub 2021 Jan 18. PMID: 33404065.

Minhas JS, Wang X, Lindley RI, Delcourt C, Song L, Woodward M, Lee TH, Broderick JP, Pontes- Neto OM, Kim JS, Ricci S, Lavados PM, Bath PM, Durham AC, Wang JG, Sharma VK, Demchuk AM, Martins SO, Chalmers J, Anderson CS, Robinson TG; ENCHANTED Investigators. Comparative effects of intensive-blood pressure versus standard-blood pressure-lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial. J Hypertens. 2021 Feb 1;39(2):280-285. doi: 10.1097/HJH.0000000000002640. PMID: 33031175.

Panerai RB, Minhas JS, Llwyd O, Salinet ASM, Katsogridakis E, Maggio P, Robinson TG. The critical closing pressure contribution to dynamic cerebral autoregulation in humans: influence of arterial partial pressure of CO2. J Physiol. 2020 Dec;598(24):5673-5685.

Hextrum S, Minhas JS, Liotta EM, Sorond FA, Naidech AM, Maas MB. Hypocapnia, ischemic lesions, and outcomes after intracerebral hemorrhage. J Neurol Sci. 2020 Nov 15;418:117139. doi: 10.1016/j.jns.2020.117139. Epub 2020 Sep 12. PMID: 32949919.

Minhas JS, Coles B, Mistri AK, Eveson DJ, Hussain ST, Potter JF, Khunti K, Robinson TG. What is the optimal blood pressure level for patients with atrial fibrillation treated with direct oral anticoagulants? J Hypertens. 2020 Sep;38(9):1820-1828. doi: 10.1097/HJH.0000000000002487. PMID: 32453015.

Panerai RB, Robinson TG, Minhas JS. The upper frequency limit of dynamic cerebral autoregulation. J Physiol. 2019 Dec;597(24):5821-5833. doi: 10.1113/JP278710. Epub 2019 Nov 28. PMID: 31671473.

Minhas JS, Panerai RB, Swienton D, Robinson TG. Feasibility of improving cerebral autoregulation in acute intracerebral hemorrhage (BREATHE-ICH) study: Results from an experimental interventional study. Int J Stroke. 2020 Aug;15(6):627-637. doi:10.1177/1747493019873690.

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Supervision

I study all aspects of acute stroke haemodynamic physiology though have a particular interest in acute intracerebral haemorrhage haemodynamics and cerebrovascular reactivity assessment.

I am interested in MD/PhD supervision in the following topic areas:

Cerebral Haemodynamics; Cerebral Autoregulation; Cerebrovascular Reactivity; Acute Stroke Care; Pre-Hospital Stroke Diagnosis

Teaching

I engage in a broad portfolio of educational commitments which have permitted attainment of Fellow status with AdvanceHE and ongoing progress towards Senior Fellow status. My commitments include:

Module Lead: MB7058_2021-22_SEM1: Physiology and Pharmacology of Cardiovascular Disease

Course Co-Director: Leicester Transcranial Doppler Course Examiner: University of Leicester Medical School

Appeals: University of Leicester Central Appeals Panellist 

Press and media

I have expertise in:

Acute Intracerebral Haemorrhage; Acute Stroke; Frailty; Vascular Neurology; Deprescribing; Hypertension

Activities

British Association of Stroke Physicians TakeUp Stroke Fellow (2020-22)

NIHR RfPB East Midlands Regional Advisory Committee Member (2021-)

Visiting Fellow/Collaborator University of British Columbia Okanagan Campus (Ainslie Lab 2020-)

Care Quality Commission Specialist Advisor (2016-) 

Awards

College of Life Sciences Lauder Prize

Quincentennial Lecturer Award Royal College of Physicians

European Stroke Organisation Young Stroke Physicians and Researchers Workshop Prize

University of Leicester Student’s Union Teaching Superstar Award

Royal College of Physicians’ Grand Round Case Presentation Prize University Hospitals of Leicester NHS Trust

Edward Boyle Memorial Award Association of Commonwealth Countries

Centre for Advancement of Interprofessional Education (CAIPE) National Conference Prize London

Qualifications

2019 Doctor of Medicine University of Leicester

2019 Fellow AdvanceHE (Higher Education Authority)

2017 Speciality Certificate Examination (SCE) Royal College of Physicians London

2016 Masters in Research University of Leicester 2014 Membership of the Royal College of Physicians London

2014 Associate Fellow Higher Education Authority

2012 Bachelor of Medicine and Surgery Norwich Medical School University of East Anglia

2007 Bachelor of Sciences in Human Genetics University of Nottingham

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