Molecular and Cell Biology

Biochemistry

Dr Alfredo De Biasio

  • Structural Biology: Cryo-EM, X-ray crystallography and Nuclear Magnetic Resonance
  • Structure and function of eukaryotic DNA polymerases
  • Molecular mechanisms of DNA replication
  • Molecular mechanisms of maintenance of DNA integrity

Professor Nicholas Brindle

  • Molecular mechanisms in signal transduction
  • Protein engineering
  • Cardiovascular disease
  • Drug discovery

Professor Mark Carr

  • Structure-based drug discovery and design
  • Antibody-assisted structure-based drug discovery

Professor Shaun Cowley

  • Regulation of gene expression via histone deacetylase (HDAC) enzymes• Embryonic stem (ES) cell differentiation
  • Generation of CRISPR/Cas9 knock-out and knock-In mice
  • Epigenetics of cancer cells

Dr Cyril Dominguez

  • Structural Biology
  • RNA biology
  • Protein-RNA interactions
  • Drug screening

Professor Ian Eperon

  • Mechanisms of RNA splicing
  • Splice site selection and alternative splicing, regulation and role of quadruplexes
  • Single molecule imaging of assembly of splicing complexes
  • Action at a distance on RNA chains: use of modelling and chemical biology

Professor Andrew Fry

  • Cell cycle control and cancer biology
  • Molecular mechanisms of mitosi
  • Microtubule cytoskeleton and centrosome organization
  • Protein kinase activation and inhibition

Professor Bibek Gooptu

  • Misfolding and conformational diseases
  • Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Ex vivo and in vitro studies of lung and liver disease

Dr Ildiko Gyory

  • Transcriptional regulation of B lymphocyte development
  • Oncogenes and tumour suppressors in B lymphoid cancer
  • Cell-type specific regulation of cell cycle genes
  • Context-dependent switch from oncogenic to tumour suppressor function

Dr Salvador Macip

  • Understanding the molecular mechanisms involved in ageing and developing strategies to slow down the process
  • Defining novel personalized therapies for B cell malignancies
  • Characterization of the p53 pathway

Dr Olga Makarova

  • Structure determination of splicing-regulatory complexes using electron microscopy
  • Analysis of function and structure of essential splicing factors
  • Evolution of splicing machinery from low to high eukaryotes
  • Splicing as a prognostic tool in cancer

Professor Peter Moody

  • Enzyme mechanisms
  • developing structural biology techniques
  • neutron crystallography

Dr Helen O'Hare

  • Molecular mechanisms of bacterial sensory perception and signal transduction
  • Role of bacterial serine threonine protein kinases in regulating bacterial physiology
  • Metabolism of Mycobacterium tuberculosis during infection
  • Regulation of gene expression in Mycobacterium tuberculosis

Professor Daniel Panne

  • Structural Biology: cryoEM and X-ray crystallography
  • Molecular mechanisms of gene regulation
  • Regulation of higher order chromatin structure and assembly
  • Signalling in the innate immune system

Dr Raj Patel

  • Mammalian cell cycle
  • Mechanism of chromosome segregation
  • The Mitotic checkpoint and apoptosis

Dr Sally Prigent

  • Receptor tyrosine kinases
  • Signalling adaptor/scaffold proteins
  • Regulation of protein complex formation in signalling pathways
  • Mechanisms of cell migration

Dr Andrey Revyakin

  • Molecular mechanisms of transcription initiation
  • Single-molecule imaging of assembly of macro-molecular complexes
  • Super-resolution microscopy
  • Bottom-up nano-engineering

Dr Thomas Schalch

  • Mechanisms of gene silencing.
  • Structural S. pombe biology.
  • Chromatin higher order structure and function.
  • Macromolecular machines in epigenetics and chromatin

Dr Ralf Schmid

  • Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
  • Functional Annotation of Protein Sequences
  • Alternative Splicing and its Effect on Protein Structure

Professor John Schwabe

  • Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
  • Molecular mechanisms of the regulation of gene expression
  • Investigating the structure and function of large histone deacetylase containing repression complexes
  • Nuclear receptors and their role in metabolism, development and disease

Dr Sue Shackleton

  • The nuclear envelope proteome and its role in human inherited disease
  • Regulation of interaction networks linking the nucleus to the cytoskeleton
  • Mechanisms controlling nuclear positioning during muscle development

Dr Kayoko Tanaka

  • Structural and functional studies of microtubule nucleation mechanism
  • Obtaining mechanistic insights into microtubule anchoring matrix
  • Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
  • Investigating signal components’ structural arrangements in GPCR-mediated Ras activation

Professor Geerten Vuister

  • Regulation of Ca2+ transport
  • NMR methods development
  • Structure validation
  • Computational tools for Biomolecular NMR

Cancer and Cell Biology

Professor Mark Carr

  • Structure-based drug discovery and design
  • Antibody-assisted structure-based drug discovery

Dr Mohammed El-Mezgueldi

  • Molecular mechanism of regulation of muscle contraction
  • Actin cytoskeleton
  • Genetic cardiomyopathies
  • Biophysical, kinetic and thermodynamic approaches

Professor Andrew Fry

  • Cell cycle control and cancer biology
  • Molecular mechanisms of mitosi
  • Microtubule cytoskeleton and centrosome organization
  • Protein kinase activation and inhibition

Dr Ildiko Gyory

  • Transcriptional regulation of B lymphocyte development
  • Oncogenes and tumour suppressors in B lymphoid cancer
  • Cell-type specific regulation of cell cycle genes
  • Context-dependent switch from oncogenic to tumour suppressor function

Dr Salvador Macip

  • Understanding the molecular mechanisms involved in ageing and developing strategies to slow down the process
  • Defining novel personalized therapies for B cell malignancies
  • Characterization of the p53 pathway

Dr Olga Makarova

  • Structure determination of splicing-regulatory complexes using electron microscopy
  • Analysis of function and structure of essential splicing factors
  • Evolution of splicing machinery from low to high eukaryotes
  • Splicing as a prognostic tool in cancer

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Dr Raj Patel

  • Mammalian cell cycle
  • Mechanism of chromosome segregation
  • The Mitotic checkpoint and apoptosis

Dr Sally Prigent

  • Receptor tyrosine kinases
  • Signalling adaptor/scaffold proteins
  • Regulation of protein complex formation in signalling pathways
  • Mechanisms of cell migration

Professor Christine Pullar

  • Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
  • Development of treatments to prevent skin and organ fibrosis
  • Biophysical analysis of how cells sense directional signals
  • Development of treatments to heal chronic wounds

Dr Sue Shackleton

  • The nuclear envelope proteome and its role in human inherited disease
  • Regulation of interaction networks linking the nucleus to the cytoskeleton
  • Mechanisms controlling nuclear positioning during muscle development

Dr Kayoko Tanaka

  • Structural and functional studies of microtubule nucleation mechanism
  • Obtaining mechanistic insights into microtubule anchoring matrix
  • Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
  • Investigating signal components’ structural arrangements in GPCR-mediated Ras activation

Cell Physiology and Pharmacology

Professor John Challiss

  • G protein-coupled receptor (GPCR) molecular pharmacologyRegulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • Understanding the importance of glial cells in CNS regulation

Dr Noel Davies

  • Physiology and biophysics of K+ channels• Regulation of K+ channels by haem and carbon monoxide
  • Regulation of cardiac Ca2+ currents by nitric oxide
  • Developing analysis software for electrophysiological data

Professor Bibek Gooptu

  • Misfolding and conformational diseases
  • Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Ex vivo and in vitro studies of lung and liver disease

Professor Martyn Mahaut-Smith

  • Signalling in the platelet and its precursor cell
  • Thrombosis, haemostasis and platelet production
  • Calcium signalling through ion channels and G-protein-coupled receptors
  • Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Professor Christine Pullar

  • Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
  • Development of treatments to prevent skin and organ fibrosis
  • Biophysical analysis of how cells sense directional signals
  • Development of treatments to heal chronic wounds

Dr Nina Storey

  • Ion channel physiology and pharmacology
  • Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
  • Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
  • Mitochondrial function and dysregulation in ischaemic heart disease

Dr Catherine Vial

  • P2 receptors
  • Extracellular nucleotide signalling
  • Airways and asthma
  • Hematic/blood cells

Dr Gary Willars

  • GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
  • Possible cellular roles of proinsulin C-peptide

Dr Jonathan Willets

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • The role of endocannabinoids in reproductive health

Cell Signalling and G Protein-Coupled Receptor Molecular Pharmacology

Professor John Challiss

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • Understanding the importance of glial cells in CNS regulation

Professor Martyn Mahaut-Smith

  • Signalling in the platelet and its precursor cell
  • Thrombosis, haemostasis and platelet production
  • Calcium signalling through ion channels and G-protein-coupled receptors
  • Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors

Professor Christine Pullar

  • Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
  • Development of treatments to prevent skin and organ fibrosis
  • Biophysical analysis of how cells sense directional signals
  • Development of treatments to heal chronic wounds

Dr Nina Storey

  • Ion channel physiology and pharmacology
  • Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
  • Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
  • Mitochondrial function and dysregulation in ischaemic heart disease

Dr Kayoko Tanaka

  • Structural and functional studies of microtubule nucleation mechanism
  • Obtaining mechanistic insights into microtubule anchoring matrix
  • Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
  • Investigating signal components’ structural arrangements in GPCR-mediated Ras activation

Dr Catherine Vial

  • P2 receptors
  • Extracellular nucleotide signalling
  • Airways and asthma
  • Hematic/blood cells

Dr Gary Willars

  • GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
  • Possible cellular roles of proinsulin C-peptide

Dr Jonathan Willets

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • The role of endocannabinoids in reproductive health

Mechanisms and Principles of Regulation of Gene Expression

Dr Alfredo De Biasio

  • Structural Biology: Cryo-EM, X-ray crystallography and Nuclear Magnetic Resonance
  • Structure and function of eukaryotic DNA polymerases
  • Molecular mechanisms of DNA replication
  • Molecular mechanisms of maintenance of DNA integrity

Dr Shaun Cowley

  • Regulation of gene expression via histone deacetylase (HDAC) enzymes
  • Embryonic stem (ES) cell differentiation
  • Generation of CRISPR/Cas9 knock-out and knock-In mice
  • Epigenetics of cancer cells

Cyril Dominguez

  • Structural Biology
  • RNA biology
  • Protein-RNA interactions
  • Drug screening

Professor Ian Eperon

  • Mechanisms of RNA splicing
  • Splice site selection and alternative splicing, regulation and role of quadruplexes
  • Single molecule imaging of assembly of splicing complexes
  • Action at a distance on RNA chains: use of modelling and chemical biology

Dr Ildiko Gyory

  • Transcriptional regulation of B lymphocyte development
  • Oncogenes and tumour suppressors in B lymphoid cancer
  • Cell-type specific regulation of cell cycle genes
  • Context-dependent switch from oncogenic to tumour suppressor function

Dr Olga Makarova

  • Structure determination of splicing-regulatory complexes using electron microscopy
  • Analysis of function and structure of essential splicing factors
  • Evolution of splicing machinery from low to high eukaryotes
  • Splicing as a prognostic tool in cancer

Dr Helen O'Hare

  • Molecular mechanisms of bacterial sensory perception and signal transduction
  • Role of bacterial serine threonine protein kinases in regulating bacterial physiology
  • Metabolism of Mycobacterium tuberculosis during infection
  • Regulation of gene expression in Mycobacterium tuberculosis

Professor Daniel Panne

  • Structural Biology: cryoEM and X-ray crystallography
  • Molecular mechanisms of gene regulation
  • Regulation of higher order chromatin structure and assembly
  • Signalling in the innate immune system

Dr Andrey Revyakin

  • Molecular mechanisms of transcription initiation
  • Single-molecule imaging of assembly of macro-molecular complexes
  • Super-resolution microscopy
  • Bottom-up nano-engineering

Dr Thomas Schalch

  • Mechanisms of gene silencing.
  • Structural S. pombe biology.
  • Chromatin higher order structure and function.
  • Macromolecular machines in epigenetics and chromatin

Professor John Schwabe

  • Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
  • Molecular mechanisms of the regulation of gene expression
  • Investigating the structure and function of large histone deacetylase containing repression complexes
  • Nuclear receptors and their role in metabolism, development and disease

Molecular Physiology of the Cardiovascular System

Professor Nicholas Brindle

  • Molecular mechanisms in signal transduction
  • Protein engineering
  • Cardiovascular disease
  • Drug discovery

Professor John Challiss

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • Understanding the importance of glial cells in CNS regulation

Dr Noel Davies

  • Physiology and biophysics of K+ channels
  • Regulation of K+ channels by haem and carbon monoxide
  • Regulation of cardiac Ca2+ currents by nitric oxide
  • Developing analysis software for electrophysiological data

Professor Martyn Mahaut-Smith

  • Signalling in the platelet and its precursor cell
  • Thrombosis, haemostasis and platelet production
  • Calcium signalling through ion channels and G-protein-coupled receptors
  • Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Dr Nina Storey

  • Ion channel physiology and pharmacology
  • Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
  • Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
  • Mitochondrial function and dysregulation in ischaemic heart disease

Dr Catherine Vial

  • P2 receptors
  • Extracellular nucleotide signalling
  • Airways and asthma
  • Hematic/blood cells

Dr Gary Willars

  • GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
  • Possible cellular roles of proinsulin C-peptide

Dr Jonathan Willets

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • The role of endocannabinoids in reproductive health

Single Molecular Approaches to Understanding Biological Systems

Professor Ian Eperon

  • Mechanisms of RNA splicing
  • Splice site selection and alternative splicing, regulation and role of quadruplexes
  • Single molecule imaging of assembly of splicing complexes
  • Action at a distance on RNA chains: use of modelling and chemical biology

Dr Andrey Revyakin

  • Molecular mechanisms of transcription initiation
  • Single-molecule imaging of assembly of macro-molecular complexes
  • Super-resolution microscopy
  • Bottom-up nano-engineering

Professor John Schwabe

  • Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
  • Molecular mechanisms of the regulation of gene expression
  • Investigating the structure and function of large histone deacetylase containing repression complexes
  • Nuclear receptors and their role in metabolism, development and disease

Structure Based Drug Discovery and Design

Professor Mark Carr
  • Structure-based drug discovery and design
  • Antibody-assisted structure-based drug discovery

Cyril Dominguez
  • Structural Biology
  • RNA biology
  • Protein-RNA interactions
  • Drug screening

Professor John Schwabe
  • Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
  • Molecular mechanisms of the regulation of gene expression
  • Investigating the structure and function of large histone deacetylase containing repression complexes
  • Nuclear receptors and their role in metabolism, development and disease

Structure, Dynamics and Assembly of Macromolecular Complexes

Dr Alfredo De Biasio

  • Structural Biology: Cryo-EM, X-ray crystallography and Nuclear Magnetic Resonance
  • Structure and function of eukaryotic DNA polymerases
  • Molecular mechanisms of DNA replication
  • Molecular mechanisms of maintenance of DNA integrity

Professor Mark Carr

  • Structure-based drug discovery and design
  • Antibody-assisted structure-based drug discovery

Dr Shaun Cowley

  • Regulation of gene expression via histone deacetylase (HDAC) enzymes
  • Embryonic stem (ES) cell differentiation
  • Generation of CRISPR/Cas9 knock-out and knock-In mice
  • Epigenetics of cancer cells

Cyril Dominguez

  • Structural Biology
  • RNA biology
  • Protein-RNA interactions
  • Drug screening

Professor Ian Eperon

  • Mechanisms of RNA splicing
  • Splice site selection and alternative splicing, regulation and role of quadruplexes
  • Single molecule imaging of assembly of splicing complexes
  • Action at a distance on RNA chains: use of modelling and chemical biology

Professor Bibek Gooptu

  • Misfolding and conformational diseases
  • Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Ex vivo and in vitro studies of lung and liver disease

Dr Olga Makarova

  • Structure determination of splicing-regulatory complexes using electron microscopy
  • Analysis of function and structure of essential splicing factors
  • Evolution of splicing machinery from low to high eukaryotes
  • Splicing as a prognostic tool in cancer

Professor Peter Moody

  • Enzyme mechanisms
  • Developing structural biology techniques
  • Neutron crystallography

Professor Daniel Panne

  • Structural Biology: cryoEM and X-ray crystallography
  • Molecular mechanisms of gene regulation
  • Regulation of higher order chromatin structure and assembly
  • Signalling in the innate immune system

Dr Andrey Revyakin

  • Molecular mechanisms of transcription initiation
  • Single-molecule imaging of assembly of macro-molecular complexes
  • Super-resolution microscopy
  • Bottom-up nano-engineering

Dr Thomas Schalch

  • Mechanisms of gene silencing
  • Structural S. pombe biology
  • Chromatin higher order structure and function
  • Macromolecular machines in epigenetics and chromatin

Dr Ralf Schmid

  • Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
  • Functional Annotation of Protein Sequences
  • Alternative Splicing and its Effect on Protein Structure

Professor John Schwabe

  • Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
  • Molecular mechanisms of the regulation of gene expression
  • Investigating the structure and function of large histone deacetylase containing repression complexes
  • Nuclear receptors and their role in metabolism, development and disease

Dr Sue Shackleton

  • The nuclear envelope proteome and its role in human inherited disease
  • Regulation of interaction networks linking the nucleus to the cytoskeleton
  • Mechanisms controlling nuclear positioning during muscle development

Dr Kayoko Tanaka

  • Structural and functional studies of microtubule nucleation mechanism
  • Obtaining mechanistic insights into microtubule anchoring matrix
  • Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
  • Investigating signal components’ structural arrangements in GPCR-mediated Ras activation

Professor Geerten Vuister

  • Regulation of Ca2+ transport
  • NMR methods development
  • Structure validation
  • Computational tools for Biomolecular NMR

Structure-Function Relationships in Ion Channels and Receptors

Professor Nicholas Brindle

  • Molecular mechanisms in signal transduction
  • Protein engineering
  • Cardiovascular disease
  • Drug discovery

Dr Noel Davies

  • Physiology and biophysics of K+ channels
  • Regulation of K+ channels by haem and carbon monoxide
  • Regulation of cardiac Ca2+ currents by nitric oxide
  • Developing analysis software for electrophysiological data

Professor Bibek Gooptu

  • Misfolding and conformational diseases
  • Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Ex vivo and in vitro studies of lung and liver disease

Professor Martyn Mahaut-Smith

  • Signalling in the platelet and its precursor cell
  • Thrombosis, haemostasis and platelet production
  • Calcium signalling through ion channels and G-protein-coupled receptors
  • Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Professor Christine Pullar

  • Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
  • Development of treatments to prevent skin and organ fibrosis
  • Biophysical analysis of how cells sense directional signals
  • Development of treatments to heal chronic wounds

Dr Ralf Schmid

  • Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
  • Functional Annotation of Protein Sequences
  • Alternative Splicing and its Effect on Protein Structure

Dr Nina Storey

  • Ion channel physiology and pharmacology
  • Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
  • Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
  • Mitochondrial function and dysregulation in ischaemic heart disease

Professor Geerten Vuister

  • Regulation of Ca2+ transport
  • NMR methods development
  • Structure validation
  • Computational tools for Biomolecular NMR

Dr Gary Willars

  • GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
  • Possible cellular roles of proinsulin C-peptide