Molecular and Cell Biology
Biochemistry
- Molecular mechanisms in signal transduction
- Protein engineering
- Cardiovascular disease
- Drug discovery
- Regulation of gene expression via histone deacetylase (HDAC) enzymes• Embryonic stem (ES) cell differentiation
- Generation of CRISPR/Cas9 knock-out and knock-In mice
- Epigenetics of cancer cells
- Structural Biology
- RNA biology
- Protein-RNA interactions
- Drug screening
- Mechanisms of RNA splicing
- Splice site selection and alternative splicing, regulation and role of quadruplexes
- Single molecule imaging of assembly of splicing complexes
- Action at a distance on RNA chains: use of modelling and chemical biology
- Cell cycle control and cancer biology
- Molecular mechanisms of mitosi
- Microtubule cytoskeleton and centrosome organization
- Protein kinase activation and inhibition
- Misfolding and conformational diseases
- Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
- Alpha1-antitrypsin deficiency and the serpinopathies
- Ex vivo and in vitro studies of lung and liver disease
- Understanding the molecular mechanisms involved in ageing and developing strategies to slow down the process
- Defining novel personalized therapies for B cell malignancies
- Characterization of the p53 pathway
- Structure determination of splicing-regulatory complexes using electron microscopy
- Analysis of function and structure of essential splicing factors
- Evolution of splicing machinery from low to high eukaryotes
- Splicing as a prognostic tool in cancer
- Enzyme mechanisms
- developing structural biology techniques
- neutron crystallography
- Molecular mechanisms of bacterial sensory perception and signal transduction
- Role of bacterial serine threonine protein kinases in regulating bacterial physiology
- Metabolism of Mycobacterium tuberculosis during infection
- Regulation of gene expression in Mycobacterium tuberculosis
- Structural Biology: cryoEM and X-ray crystallography
- Molecular mechanisms of gene regulation
- Regulation of higher order chromatin structure and assembly
- Signalling in the innate immune system
Dr Raj Patel
- Mammalian cell cycle
- Mechanism of chromosome segregation
- The Mitotic checkpoint and apoptosis
Dr Sally Prigent
- Receptor tyrosine kinases
- Signalling adaptor/scaffold proteins
- Regulation of protein complex formation in signalling pathways
- Mechanisms of cell migration
- Mechanisms of gene silencing.
- Structural S. pombe biology.
- Chromatin higher order structure and function.
- Macromolecular machines in epigenetics and chromatin
- Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
- Functional Annotation of Protein Sequences
- Alternative Splicing and its Effect on Protein Structure
- Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
- Molecular mechanisms of the regulation of gene expression
- Investigating the structure and function of large histone deacetylase containing repression complexes
- Nuclear receptors and their role in metabolism, development and disease
- The nuclear envelope proteome and its role in human inherited disease
- Regulation of interaction networks linking the nucleus to the cytoskeleton
- Mechanisms controlling nuclear positioning during muscle development
- Structural and functional studies of microtubule nucleation mechanism
- Obtaining mechanistic insights into microtubule anchoring matrix
- Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
- Investigating signal components’ structural arrangements in GPCR-mediated Ras activation
- Regulation of Ca2+ transport
- NMR methods development
- Structure validation
- Computational tools for Biomolecular NMR
Dr Christopher Switzer
- Cellular Chemistry
- Oxidative Stress
- Mechanisms of Cellular Dysfunction
- Bioinorganic Chemistry
Dr Yolanda Markaki
- Quantitative super-resolution imaging of nuclear landscapes
- Genome organization and nuclear function
- Epigenetic regulation of pluripotency and differentiation
- X-chromosome inactivation and long non-coding RNAs
Cancer and Cell Biology
- Cell cycle control and cancer biology
- Molecular mechanisms of mitosi
- Microtubule cytoskeleton and centrosome organization
- Protein kinase activation and inhibition
- Understanding the molecular mechanisms involved in ageing and developing strategies to slow down the process
- Defining novel personalized therapies for B cell malignancies
- Characterization of the p53 pathway
- Centrosome structure and function
- Molecular mechanisms of cilia function
- Mechanisms of genomic stability during the cell cycle
- Live cell imaging of organelle function
- Structure determination of splicing-regulatory complexes using electron microscopy
- Analysis of function and structure of essential splicing factors
- Evolution of splicing machinery from low to high eukaryotes
- Splicing as a prognostic tool in cancer
- Ion channel physiology and pharmacology
- Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
- Cellular cardiac electrophysiology and mechanisms of arrhythmia
- The role of hERG and hEAG channels in cancer initiation and progression
Dr Raj Patel
- Mammalian cell cycle
- Mechanism of chromosome segregation
- The Mitotic checkpoint and apoptosis
Dr Sally Prigent
- Receptor tyrosine kinases
- Signalling adaptor/scaffold proteins
- Regulation of protein complex formation in signalling pathways
- Mechanisms of cell migration
- The nuclear envelope proteome and its role in human inherited disease
- Regulation of interaction networks linking the nucleus to the cytoskeleton
- Mechanisms controlling nuclear positioning during muscle development
- Structural and functional studies of microtubule nucleation mechanism
- Obtaining mechanistic insights into microtubule anchoring matrix
- Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
- Investigating signal components’ structural arrangements in GPCR-mediated Ras activation
Dr Christopher Switzer
- Cellular Chemistry
- Oxidative Stress
- Mechanisms of Cellular Dysfunction
- Bioinorganic Chemistry
Dr Yolanda Markaki
- Quantitative super-resolution imaging of nuclear landscapes
- Genome organization and nuclear function
- Epigenetic regulation of pluripotency and differentiation
- X-chromosome inactivation and long non-coding RNAs
Cell Physiology and Pharmacology
- G protein-coupled receptor (GPCR) molecular pharmacologyRegulating GPCR function in the cardiovascular system
- Regulating signal transduction in health and disease
- Understanding the importance of glial cells in CNS regulation
- Misfolding and conformational diseases
- Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
- Alpha1-antitrypsin deficiency and the serpinopathies
- Ex vivo and in vitro studies of lung and liver disease
- Centrosome structure and function
- Molecular mechanisms of cilia function
- Mechanisms of genomic stability during the cell cycle
- Live cell imaging of organelle function
- Signalling in the platelet and its precursor cell
- Thrombosis, haemostasis and platelet production
- Calcium signalling through ion channels and G-protein-coupled receptors
- Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors
- Ion channel physiology and pharmacology
- Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
- Cellular cardiac electrophysiology and mechanisms of arrhythmia
- The role of hERG and hEAG channels in cancer initiation and progression
Professor Christine Pullar
- Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
- Development of treatments to prevent skin and organ fibrosis
- Biophysical analysis of how cells sense directional signals
- Development of treatments to heal chronic wounds
- Ion channel physiology and pharmacology
- Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
- Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
- Mitochondrial function and dysregulation in ischaemic heart disease
- P2 receptors
- Extracellular nucleotide signalling
- Airways and asthma
- Hematic/blood cells
- GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
- Possible cellular roles of proinsulin C-peptide
- G protein-coupled receptor (GPCR) molecular pharmacology
- Regulating GPCR function in the cardiovascular system
- Regulating signal transduction in health and disease
- The role of endocannabinoids in reproductive health
Cell Signalling and G Protein-Coupled Receptor Molecular Pharmacology
- G protein-coupled receptor (GPCR) molecular pharmacology
- Regulating GPCR function in the cardiovascular system
- Regulating signal transduction in health and disease
- Understanding the importance of glial cells in CNS regulation
- Signalling in the platelet and its precursor cell
- Thrombosis, haemostasis and platelet production
- Calcium signalling through ion channels and G-protein-coupled receptors
- Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors
Professor Christine Pullar
- Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
- Development of treatments to prevent skin and organ fibrosis
- Biophysical analysis of how cells sense directional signals
- Development of treatments to heal chronic wounds
- Ion channel physiology and pharmacology
- Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
- Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
- Mitochondrial function and dysregulation in ischaemic heart disease
- Structural and functional studies of microtubule nucleation mechanism
- Obtaining mechanistic insights into microtubule anchoring matrix
- Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
- Investigating signal components’ structural arrangements in GPCR-mediated Ras activation
- P2 receptors
- Extracellular nucleotide signalling
- Airways and asthma
- Hematic/blood cells
- GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
- Possible cellular roles of proinsulin C-peptide
- G protein-coupled receptor (GPCR) molecular pharmacology
- Regulating GPCR function in the cardiovascular system
- Regulating signal transduction in health and disease
- The role of endocannabinoids in reproductive health
Mechanisms and Principles of Regulation of Gene Expression
Dr Alfredo De Biasio
- Structural Biology: Cryo-EM, X-ray crystallography and Nuclear Magnetic Resonance
- Structure and function of eukaryotic DNA polymerases
- Molecular mechanisms of DNA replication
- Molecular mechanisms of maintenance of DNA integrity
- Regulation of gene expression via histone deacetylase (HDAC) enzymes
- Embryonic stem (ES) cell differentiation
- Generation of CRISPR/Cas9 knock-out and knock-In mice
- Epigenetics of cancer cells
- Structural Biology
- RNA biology
- Protein-RNA interactions
- Drug screening
- Mechanisms of RNA splicing
- Splice site selection and alternative splicing, regulation and role of quadruplexes
- Single molecule imaging of assembly of splicing complexes
- Action at a distance on RNA chains: use of modelling and chemical biology
- Structure determination of splicing-regulatory complexes using electron microscopy
- Analysis of function and structure of essential splicing factors
- Evolution of splicing machinery from low to high eukaryotes
- Splicing as a prognostic tool in cancer
- Molecular mechanisms of bacterial sensory perception and signal transduction
- Role of bacterial serine threonine protein kinases in regulating bacterial physiology
- Metabolism of Mycobacterium tuberculosis during infection
- Regulation of gene expression in Mycobacterium tuberculosis
- Structural Biology: cryoEM and X-ray crystallography
- Molecular mechanisms of gene regulation
- Regulation of higher order chromatin structure and assembly
- Signalling in the innate immune system
- Mechanisms of gene silencing.
- Structural S. pombe biology.
- Chromatin higher order structure and function.
- Macromolecular machines in epigenetics and chromatin
- Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
- Molecular mechanisms of the regulation of gene expression
- Investigating the structure and function of large histone deacetylase containing repression complexes
- Nuclear receptors and their role in metabolism, development and disease
Dr Michael Tellier
- Regulation of transcription (initiation, elongation, termination)
- Mechanisms of RNA splicing and mRNA cleavage and polyadenylation
- Protein phosphorylation (kinases and phosphatases)
- OMICS approaches: genomics, transcriptomics, (phospho-)proteomics, bioinformatics
Dr Yolanda Markaki
- Quantitative super-resolution imaging of nuclear landscapes
- Genome organization and nuclear function
- Epigenetic regulation of pluripotency and differentiation
- X-chromosome inactivation and long non-coding RNAs
Molecular Physiology of the Cardiovascular System
- Molecular mechanisms in signal transduction
- Protein engineering
- Cardiovascular disease
- Drug discovery
- G protein-coupled receptor (GPCR) molecular pharmacology
- Regulating GPCR function in the cardiovascular system
- Regulating signal transduction in health and disease
- Understanding the importance of glial cells in CNS regulation
- Signalling in the platelet and its precursor cell
- Thrombosis, haemostasis and platelet production
- Calcium signalling through ion channels and G-protein-coupled receptors
- Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors
- Ion channel physiology and pharmacology
- Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
- Cellular cardiac electrophysiology and mechanisms of arrhythmia
- The role of hERG and hEAG channels in cancer initiation and progression
- Ion channel physiology and pharmacology
- Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
- Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
- Mitochondrial function and dysregulation in ischaemic heart disease
- P2 receptors
- Extracellular nucleotide signalling
- Airways and asthma
- Hematic/blood cells
- GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
- Possible cellular roles of proinsulin C-peptide
- G protein-coupled receptor (GPCR) molecular pharmacology
- Regulating GPCR function in the cardiovascular system
- Regulating signal transduction in health and disease
- The role of endocannabinoids in reproductive health
Single Molecule Approaches to Understanding Biological Systems
- Mechanisms of RNA splicing
- Splice site selection and alternative splicing, regulation and role of quadruplexes
- Single molecule imaging of assembly of splicing complexes
- Action at a distance on RNA chains: use of modelling and chemical biology
- Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
- Molecular mechanisms of the regulation of gene expression
- Investigating the structure and function of large histone deacetylase containing repression complexes
- Nuclear receptors and their role in metabolism, development and disease
Dr Yolanda Markaki
- Quantitative super-resolution imaging of nuclear landscapes
- Genome organization and nuclear function
- Epigenetic regulation of pluripotency and differentiation
- X-chromosome inactivation and long non-coding RNAs
Structure Based Drug Discovery and Design
- Structural Biology
- RNA biology
- Protein-RNA interactions
- Drug screening
Professor John Schwabe
- Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
- Molecular mechanisms of the regulation of gene expression
- Investigating the structure and function of large histone deacetylase containing repression complexes
- Nuclear receptors and their role in metabolism, development and disease
Structure, Dynamics and Assembly of Macromolecular Complexes
Dr Alfredo De Biasio
- Structural Biology: Cryo-EM, X-ray crystallography and Nuclear Magnetic Resonance
- Structure and function of eukaryotic DNA polymerases
- Molecular mechanisms of DNA replication
- Molecular mechanisms of maintenance of DNA integrity
- Regulation of gene expression via histone deacetylase (HDAC) enzymes
- Embryonic stem (ES) cell differentiation
- Generation of CRISPR/Cas9 knock-out and knock-In mice
- Epigenetics of cancer cells
- Structural Biology
- RNA biology
- Protein-RNA interactions
- Drug screening
- Mechanisms of RNA splicing
- Splice site selection and alternative splicing, regulation and role of quadruplexes
- Single molecule imaging of assembly of splicing complexes
- Action at a distance on RNA chains: use of modelling and chemical biology
- Misfolding and conformational diseases
- Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
- Alpha1-antitrypsin deficiency and the serpinopathies
- Ex vivo and in vitro studies of lung and liver disease
- Centrosome structure and function
- Molecular mechanisms of cilia function
- Mechanisms of genomic stability during the cell cycle
- Live cell imaging of organelle function
- Structure determination of splicing-regulatory complexes using electron microscopy
- Analysis of function and structure of essential splicing factors
- Evolution of splicing machinery from low to high eukaryotes
- Splicing as a prognostic tool in cancer
- Enzyme mechanisms
- Developing structural biology techniques
- Neutron crystallography
- Structural Biology: cryoEM and X-ray crystallography
- Molecular mechanisms of gene regulation
- Regulation of higher order chromatin structure and assembly
- Signalling in the innate immune system
- Mechanisms of gene silencing
- Structural S. pombe biology
- Chromatin higher order structure and function
- Macromolecular machines in epigenetics and chromatin
- Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
- Functional Annotation of Protein Sequences
- Alternative Splicing and its Effect on Protein Structure
- Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
- Molecular mechanisms of the regulation of gene expression
- Investigating the structure and function of large histone deacetylase containing repression complexes
- Nuclear receptors and their role in metabolism, development and disease
- The nuclear envelope proteome and its role in human inherited disease
- Regulation of interaction networks linking the nucleus to the cytoskeleton
- Mechanisms controlling nuclear positioning during muscle development
- Structural and functional studies of microtubule nucleation mechanism
- Obtaining mechanistic insights into microtubule anchoring matrix
- Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
- Investigating signal components’ structural arrangements in GPCR-mediated Ras activation
- Regulation of Ca2+ transport
- NMR methods development
- Structure validation
- Computational tools for Biomolecular NMR
Dr Yolanda Markaki
- Quantitative super-resolution imaging of nuclear landscapes
- Genome organization and nuclear function
- Epigenetic regulation of pluripotency and differentiation
- X-chromosome inactivation and long non-coding RNAs
Structure-Function Relationships in Ion Channels and Receptors
- Molecular mechanisms in signal transduction
- Protein engineering
- Cardiovascular disease
- Drug discovery
- Misfolding and conformational diseases
- Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
- Alpha1-antitrypsin deficiency and the serpinopathies
- Ex vivo and in vitro studies of lung and liver disease
- Signalling in the platelet and its precursor cell
- Thrombosis, haemostasis and platelet production
- Calcium signalling through ion channels and G-protein-coupled receptors
- Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors
- Ion channel physiology and pharmacology
- Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
- Cellular cardiac electrophysiology and mechanisms of arrhythmia
- The role of hERG and hEAG channels in cancer initiation and progression
- Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
- Functional Annotation of Protein Sequences
- Alternative Splicing and its Effect on Protein Structure
- Ion channel physiology and pharmacology
- Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
- Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
- Mitochondrial function and dysregulation in ischaemic heart disease
- Regulation of Ca2+ transport
- NMR methods development
- Structure validation
- Computational tools for Biomolecular NMR
- GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
- Possible cellular roles of proinsulin C-peptide