My research career in Physiology and Pharmacology started with a PhD on voltage-gated ion channels (1983-86) under the supervision of Dr Robert Meech at the University of Bristol. This was followed by Post-Doc positions in Toronto (lymphocyte ion channels with Dr Lyanne Schlichter) Cambridge (platelet ion channels with Drs Tim Rink and Stewart Sage) and San Diego (calcium and cyclic nucleotide signalling with Prof Roger Tsien). In 1992 I returned to Cambridge funded initially by a British Heart Foundation Lectureship to continue work on platelet ion channels and calcium signalling. During this time I became fascinated by megakaryocyte function. In 2007 I moved to a Chair in Cellular Physiology at the University of Leicester. My long-standing interest in using state of the art techniques to study biological systems led to an appointment as Academic Head of Core Biotechnology Services (2015-2018) alongside teaching and research activities. In addition as current Chair of the Disability Equality Action Group I advocate for improved support for disabled University staff.
Wright JR, Jones S, Parvathy S, Kaczmarek LK, Forsythe I, Farndale RW, Gibbins JM, Mahaut-Smith MP. (2021) The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen. Platelets Aug 4:1-11. doi: 10.1080/09537104.2021.1942818.
Bye, A.P, Gibbins, J.M. & Mahaut-Smith, M.P. (2020). Ca2+ waves coordinate purinergic receptor-evoked integrin activation and polarisation. Science Signaling Vol. 13, Issue 615, eaav7354. F1000 research paper.
Mahaut-Smith, M.P., Evans, R.J. & Vial, C. (2019). Development of a P2X1-eYFP receptor knock-in mouse to track receptors in real time. Purinergic Signaling, 15(3):397-402 https://doi.org/10.1007/s11302-019-09666-1
Ilkan, Z., Watson, S., Watson, S.P. & Mahaut-Smith, M.P. (2018). P2X1 receptors amplify FcγRIIa-induced calcium increases and functional responses in human platelets. Thrombosis & Haemostasis. 118:369-380
Ilkan Z., Wright JR, Goodall A.H., Gibbins J.M., Jones C.I. & Mahaut-Smith M.P. (2017). Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. J.Biol.Chem. 292:9204-9217.
Osman S., Taylor, K.A., Allcock, N., Rainbow, R.D. & Mahaut-Smith, M.P. (2016). Detachment of surface membrane invagination systems by cationic amphiphilic drugs. Scientific Reports 6:18536.
Jones, S., Evans, R.J. & Mahaut-Smith, M.P. (2014) Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation. Molecular Pharmacology 86:243-51
Taylor, K.A., Wright, J.R., Vial, C., Evans, R.J. & Mahaut-Smith, M.P. (2014). Amplification of human platelet activation by surface pannexin-1 channels. Journal of Thrombosis & Haemostasis. 12:987-98.
Vaiyapuri, S., Jones, C.I., Sasikumar, P.. Moraes, L.A., Munger, S.J., Wright, J.R., Ali, M.S., Sage, T., Kaiser, W.J., Tucker, K.L., Stain, C.J., Bye, A.P., Jones, S., Oviedo-Orta, E., Simon, A.S., Mahaut-Smith, M.P., & Gibbins, J.M. (2012). Gap Junctions and Connexin Hemichannels Underpin Haemostasis and Thrombosis. Circulation 125, 2479-2491.
Fung, C.Y.E, Jones, S., Ntrakwah, A., Naseem, K.M. Farndale, R.W. & Mahaut-Smith, M.P. (2012). Platelet Ca2+ responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors. Blood 119, 3613-3621.