Respiratory Sciences

Professor Peter Bradding

• Pathophysiology of asthma with a particular focus on ion channels and mast cell-airway smooth muscle

Professor Chris Brightling

• Immunopathogenesis of airway disease namely asthma, chronic obstructive pulmonary disease and chronic cough

Professor Andrea Cooper

• Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
• The role of early innate events in driving coordinated immune responses
• The role of cytokines and chemokines in initiation, expression and regulation of immunity
• The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
• The role of the inflamed environment in regulating the expression of immunity

Professor David Cousins

• T-cell function in respiratory disease, in particular asthma and Chronic Obstructive Pulmonary Disease
• Development and function of human Innate Lymphoid Cells (ILCs)

Professor Bibek Gooptu

• Ex vivo and in vitro studies of lung and liver disease
• Use of structural biology methods to understand disease mechanisms and develop new therapies
• Interstitial lung disease, inflammation and fibrosis
• Alpha1-antitrypsin deficiency and the serpinopathies
• Misfolding and conformational diseases

Dr Neil Greening

• Exacerbations of COPD
• Systemic consequences of COPD, including sarcopenia and muscle dysfunction
• Effects of hospitalisation on patient health

Dr Pranab Haldar

• Interstitial lung disease and Idiopathic pulmonary fibrosis
• Ex vivo studies of lung disease
• Pathophysiology of Idiopathic pulmonary fibrosis
• Understanding cellular responses and mechanisms driving tissue remodelling in fibriotic lung disease

Dr Katy Roach

• Interstitial lung disease and Idiopathic pulmonary fibrosis
• Ex vivo studies of lung disease
• Pathophysiology of Idiopathic pulmonary fibrosis
• Understanding cellular responses and mechanisms driving tissue remodelling in fibriotic lung disease

Dr Dominick Shaw

• Severe asthma; airway biology through to epidemiology
• Medical technology; digital inhalers and wearables for respiratory health
• Prognostic scoring; early warning scores to improve clinical outcomes in respiratory disease
• Respiratory health provision for disadvantaged groups

Professor Michael Steiner

• Diagnosis and management of COPD
• Epidemiology and population health in respiratory disease
• Exercise and rehabilitation in respiratory disease
• Nutrition and muscle health in respiratory disease

Dr Luke Baker

• Disease agnostic mechanisms of sarcopenia in MLTCs
• Role of resolution physiology in muscle biology
• Acute illness and it's multi-factorial effect on skeletal muscle

Dr Rachael Evans

• pathophysiology, phenotypes, treatments and clinical care for Long Covid
• diagnosis and management of breathlessness
• role of exercise rehabilitation for adults with long term conditions

Dr Neil Greening

• Exacerbations of COPD
• Systemic consequences of COPD, including sarcopenia and muscle dysfunction
• Effects of hospitalisation on patient health

Dr Mark Orme

• Exercise-based rehabilitation (UK and global health)
• Digital health technologies for disease self-management
• Measurement and evaluation of 24-hour movement behaviours (physical activity, sedentary behaviour, sleep)
• Effects of 24-hour movement behaviours on health

Professor Sally Singh

• Exercise rehabilitation in respiratory and cardiac disease, long covid and multiple long term conditions
• Supporting allied health professionals to develop a research career
• Development of culturally appropriate rehabilitation in low- and middle-income countries
• Development of digital solutions to deliver rehabilitation for multiple long-term conditions

Professor Mike Barer

• Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis 

Dr Primrose Freestone

• Studies into microbial endocrinology
• Relationship between stress and stress hormones and the progress of human and animal infection
• Fresh produce safety

Dr Natalie Garton

• Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
• Spectroscopic methods to monitor bacterial adaptation

Professor Galina Mukamolova

• Molecular mechanisms of bacterial dormancy and resuscitation
• Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
• Antimicrobial tolerance
• Biomarkers of non-replicating persistence

Dr Helen O'Hare

• Bacterial sensory perception and signal transduction
• Regulation of bacterial metabolism (Mycobacterium tuberculosis)  

Dr John E Pearl

• Non-culture detection of mycobacteria in the environment to understand the metabolic configuration and respiratory state associated with their capacity to survive and persist
• Investigation of phenotypic development in NTM as a response to challenging environments with an emphasis on metabolic remodelling and respiration
• Development of constraints-based genome scale models of mycobacteria to understand bacterial fitness within the context of challenging environments using the COBRA toolbox and MATLAB
• The interaction between the environment and mycobacteria during aerosolization to better understand what factors are important for airborne transmission.
• Airflow measurement and computational fluid dynamic modelling of experimental aerosol exposure to predict lower airway particulate deposition.
• Production engineering of an anatomically realistic mouse training device for intravenous and intraperitoneal injection skill development 

Dr Hasan Yesilkaya

• Molecular analysis of bacterial virulence determinants of important human pathogens such as Klebsiella pneumoniae and Streptococcus pneumoniae.
• Understanding in vivo survival mechanisms of microbes

Dr Erol Gaillard

• Airway epithelial cell biology especially the role of epithelial ion channels and their impact on mucociliary clearance in conditions like asthma, cystic fibrosis and chronic obstructive pulmonary disease

Professor Manish Pareek

• Diagnosis of latent and active TB
• Migrant health