Respiratory Sciences
Microbial Sciences
- Molecular and cellular studies of host and bacterial responses in infection and disease and pathogen/environmental interactions especially involving Streptococcus pneumoniae and Listeria monocytogenes
- Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis
- Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
- The role of early innate events in driving coordinated immune responses
- The role of cytokines and chemokines in initiation, expression and regulation of immunity
- The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
- The role of the inflamed environment in regulating the expression of immunity
- Studies into microbial endocrinology
- Relationship between stress and stress hormones and the progress of human and animal infection
- Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
- Spectroscopic methods to monitor bacterial adaptation
- Molecular mechanisms of bacterial dormancy and resuscitation
- Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
- Antimicrobial tolerance
- Biomarkers of non-replicating persistence
- Bacterial sensory perception and signal transduction
- Regulation of bacterial metabolism (Mycobacterium tuberculosis)
- Understanding the role fungal allergy and/or colonisation plays in causing and exacerbating respiratory diseases such as asthma, COPD or cystic fibrosis
- Investigating the interaction between the respiratory mycobiome and bacteriome
- Understanding the effect antifungal or antibacterial drugs may have on the mycobiome and bacteriome
- Developing approaches to identify and quantify fungal exposure in the environment
- Understanding the relationship between fungal exposure and respiratory health
- Investigating the role the environmental use of fungicides may have on the development of resistance to antifungal drugs used clinically
- Respiratory
- Mediators of mucosal immunity
- Microbial
- Vascular inflammation in sepsis
- Renal
- Immune complex mediated inflammation
- Molecular changes that occur during initiation of the classical and lectin pathways of complement activation
- Characterising the interactions between components that trigger complement activation
- Molecular analysis of bacterial virulence determinants of important human pathogens such as Klebsiella pneumoniae and Streptococcus pneumoniae.
- Understanding in vivo survival mechanisms of microbes
Nephrology
- Genetics and epigenetics of IgA Nephropathy
- Role of the innate immune system in IgA Nephropathy
- Novel therapies in IgA Nephropathy
- IgA structure and function
- Lymphocyte trafficking and IgA Nephropathy
- Role of complement in glomerular injury in IgA Nephropathy
- Metabolic basis of catabolic states, in particular the stimulation of protein wasting in skeletal muscle in response to metabolic acidosis
- Cellular Mechanisms and novel interventions in proteinuric progressive renal disease and diabetic nephropathy
- Complement pathways in tubulointerstitial disease
- Study of microparticles as novel biomarkers of cardiovascular disease in uraemia
- Community studies of chronic kidney disease and acute kidney injury risk factors, and implementation of novel management strategies
- Mechanisms of left ventricular hypertrophy, inflammation and fibrosis in CKD
- Interventions to improve cardiovascular outcomes in dialysis patients
- Novel biomarkers for the assessment of cardiovascular risk in patients with CKD
- Respiratory
- Mediators of mucosal immunity
- Microbial
- Vascular inflammation in sepsis
- Renal
- Immune complex mediated inflammation
- Therapeutic use of exercise in CKD
- Molecular mechanisms of muscle wasting in human CKD
Respiratory Sciences
- Use of translational bench-to-bedside research to identify novel therapeutic approaches for the treatment of chronic obstructive pulmonary disease
- Molecular and cellular studies of host and bacterial responses in infection and disease and pathogen/environmental interactions especially involving Streptococcus pneumoniae and Listeria monocytogenes
- Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis
- Respiratory physiology based in a clinical environment
- Mechanics of breathing, development and clinical physiology
- Pathophysiology of asthma with a particular focus on ion channels and mast cell-airway smooth muscle
- Immunopathogenesis of airway disease namely asthma, chronic obstructive pulmonary disease and chronic cough
- Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
- The role of early innate events in driving coordinated immune responses
- The role of cytokines and chemokines in initiation, expression and regulation of immunity
- The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
- The role of the inflamed environment in regulating the expression of immunity
- T-cell function in respiratory disease, in particular asthma and Chronic Obstructive Pulmonary Disease
- Development and function of human Innate Lymphoid Cells (ILCs)
- Airway epithelial cell biology especially the role of epithelial ion channels and their impact on mucociliary clearance in conditions like asthma, cystic fibrosis and chronic obstructive pulmonary disease
- Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
- Spectroscopic methods to monitor bacterial adaptation
- Ex vivo and in vitro studies of lung and liver disease
- Use of structural biology methods to understand disease mechanisms and develop new therapies
- Interstitial lung disease, inflammation and fibrosis
- Alpha1-antitrypsin deficiency and the serpinopathies
- Misfolding and conformational diseases
- Epidemiology of latent and active tuberculosis
- Molecular mechanisms of bacterial dormancy and resuscitation
- Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
- Antimicrobial tolerance
- Biomarkers of non-replicating persistence
- Understanding the role fungal allergy and/or colonisation plays in causing and exacerbating respiratory diseases such as asthma, COPD or cystic fibrosis
- Investigating the interaction between the respiratory mycobiome and bacteriome
- Understanding the effect antifungal or antibacterial drugs may have on the mycobiome and bacteriome
- Developing approaches to identify and quantify fungal exposure in the environment
- Understanding the relationship between fungal exposure and respiratory health
- Investigating the role the environmental use of fungicides may have on the development of resistance to antifungal drugs used clinically
- Mechanisms of airway remodelling and repair in asthma
- Severe asthma phenotyping
- Biomarkers of severe asthma
- Structure function relationships in asthma with a focus on computational models
- Applied physiology and functional imaging (MRI and CT systems)
- Phenotyping acute exacerbations of cardio respiratory disease
- Exhaled breath metabolomics
- Respiratory
- Mediators of mucosal immunity
- Microbial
- Vascular inflammation in sepsis
- Renal
- Immune complex mediated inflammation
Professor Andy Wardlaw
- Eosinophil biology, particularly as it relates to the pathogenesis of asthma
- Drug development in asthma
- Hypereosinophilic disease
- Fungal diseases of the lung, in particular allergic fungal airway disease
Tuberculosis
- Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis
- Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
- The role of early innate events in driving coordinated immune responses
- The role of cytokines and chemokines in initiation, expression and regulation of immunity
- The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
- The role of the inflamed environment in regulating the expression of immunity
- Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
- Spectroscopic methods to monitor bacterial adaptation
- Epidemiology of latent and active tuberculosis
- Molecular mechanisms of bacterial dormancy and resuscitation
- Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
- Antimicrobial tolerance
- Biomarkers of non-replicating persistence
- Bacterial sensory perception and signal transduction
- Regulation of bacterial metabolism (Mycobacterium tuberculosis)