Respiratory Sciences

Microbial Sciences

Professor Peter Andrew

  • Molecular and cellular studies of host and bacterial responses in infection and disease and pathogen/environmental interactions especially involving Streptococcus pneumoniae and Listeria monocytogenes

Professor Mike Barer

  • Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis

Professor Andrea Cooper

  • Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
  • The role of early innate events in driving coordinated immune responses
  • The role of cytokines and chemokines in initiation, expression and regulation of immunity
  • The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
  • The role of the inflamed environment in regulating the expression of immunity

Dr Primrose Freestone

  • Studies into microbial endocrinology
  • Relationship between stress and stress hormones and the progress of human and animal infection

Dr Natalie Garton

  • Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
  • Spectroscopic methods to monitor bacterial adaptation

Dr Galina Mukamolova

  • Molecular mechanisms of bacterial dormancy and resuscitation
  • Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
  • Antimicrobial tolerance
  • Biomarkers of non-replicating persistence

Dr Helen O'Hare

  • Bacterial sensory perception and signal transduction
  • Regulation of bacterial metabolism (Mycobacterium tuberculosis)

Dr Catherine Pashley

  • Understanding the role fungal allergy and/or colonisation plays in causing and exacerbating respiratory diseases such as asthma, COPD or cystic fibrosis
  • Investigating the interaction between the respiratory mycobiome and bacteriome
  • Understanding the effect antifungal or antibacterial drugs may have on the mycobiome and bacteriome
  • Developing approaches to identify and quantify fungal exposure in the environment
  • Understanding the relationship between fungal exposure and respiratory health
  • Investigating the role the environmental use of fungicides may have on the development of resistance to antifungal drugs used clinically

Dr Cordula Stover

  • Respiratory
  • Mediators of mucosal immunity
  • Microbial
  • Vascular inflammation in sepsis
  • Renal
  • Immune complex mediated inflammation

Professor Russell Wallis

  • Molecular changes that occur during initiation of the classical and lectin pathways of complement activation
  • Characterising the interactions between components that trigger complement activation

Dr Hasan Yesilkaya

  • Molecular analysis of bacterial virulence determinants of important human pathogens such as Klebsiella pneumoniae and Streptococcus pneumoniae.
  • Understanding in vivo survival mechanisms of microbes

Nephrology

Dr Jonathan Barratt

  • Genetics and epigenetics of IgA Nephropathy
  • Role of the innate immune system in IgA Nephropathy
  • Novel therapies in IgA Nephropathy
  • IgA structure and function
  • Lymphocyte trafficking and IgA Nephropathy
  • Role of complement in glomerular injury in IgA Nephropathy

Dr Alan Bevington

  • Metabolic basis of catabolic states, in particular the stimulation of protein wasting in skeletal muscle in response to metabolic acidosis

Professor Nigel Brunskill

  • Cellular Mechanisms and novel interventions in proteinuric progressive renal disease and diabetic nephropathy
  • Complement pathways in tubulointerstitial disease
  • Study of microparticles as novel biomarkers of cardiovascular disease in uraemia
  • Community studies of chronic kidney disease and acute kidney injury risk factors, and implementation of novel management strategies

Dr James Burton

  • Mechanisms of left ventricular hypertrophy, inflammation and fibrosis in CKD
  • Interventions to improve cardiovascular outcomes in dialysis patients
  • Novel biomarkers for the assessment of cardiovascular risk in patients with CKD

Dr Cordula Stover

  • Respiratory
  • Mediators of mucosal immunity
  • Microbial
  • Vascular inflammation in sepsis
  • Renal
  • Immune complex mediated inflammation

Dr Emma Watson

  • Therapeutic use of exercise in CKD
  • Molecular mechanisms of muscle wasting in human CKD

Respiratory Sciences

Dr Yassine Amrani

  • Use of translational bench-to-bedside research to identify novel therapeutic approaches for the treatment of chronic obstructive pulmonary disease

Professor Peter Andrew

  • Molecular and cellular studies of host and bacterial responses in infection and disease and pathogen/environmental interactions especially involving Streptococcus pneumoniae and Listeria monocytogenes

Professor Mike Barer

  • Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis

Dr Caroline Beardsmore

  • Respiratory physiology based in a clinical environment
  • Mechanics of breathing, development and clinical physiology

Professor Peter Bradding

  • Pathophysiology of asthma with a particular focus on ion channels and mast cell-airway smooth muscle

Professor Chris Brightling

  • Immunopathogenesis of airway disease namely asthma, chronic obstructive pulmonary disease and chronic cough

Professor Andrea Cooper

  • Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
  • The role of early innate events in driving coordinated immune responses
  • The role of cytokines and chemokines in initiation, expression and regulation of immunity
  • The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
  • The role of the inflamed environment in regulating the expression of immunity

Professor David Cousins

  • T-cell function in respiratory disease, in particular asthma and Chronic Obstructive Pulmonary Disease
  • Development and function of human Innate Lymphoid Cells (ILCs)

Dr Erol Gaillard

  • Airway epithelial cell biology especially the role of epithelial ion channels and their impact on mucociliary clearance in conditions like asthma, cystic fibrosis and chronic obstructive pulmonary disease

Dr Natalie Garton

  • Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
  • Spectroscopic methods to monitor bacterial adaptation

Professor Bibek Gooptu

  • Ex vivo and in vitro studies of lung and liver disease
  • Use of structural biology methods to understand disease mechanisms and develop new therapies
  • Interstitial lung disease, inflammation and fibrosis
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Misfolding and conformational diseases

Dr Pranab Haldar

  • Epidemiology of latent and active tuberculosis

Dr Galina Mukamolova

  • Molecular mechanisms of bacterial dormancy and resuscitation
  • Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
  • Antimicrobial tolerance
  • Biomarkers of non-replicating persistence

Dr Catherine Pashley

  • Understanding the role fungal allergy and/or colonisation plays in causing and exacerbating respiratory diseases such as asthma, COPD or cystic fibrosis
  • Investigating the interaction between the respiratory mycobiome and bacteriome
  • Understanding the effect antifungal or antibacterial drugs may have on the mycobiome and bacteriome
  • Developing approaches to identify and quantify fungal exposure in the environment
  • Understanding the relationship between fungal exposure and respiratory health
  • Investigating the role the environmental use of fungicides may have on the development of resistance to antifungal drugs used clinically

Professor Salman Siddiqui

  • Mechanisms of airway remodelling and repair in asthma
  • Severe asthma phenotyping
  • Biomarkers of severe asthma
  • Structure function relationships in asthma with a focus on computational models
  • Applied physiology and functional imaging (MRI and CT systems)
  • Phenotyping acute exacerbations of cardio respiratory disease
  • Exhaled breath metabolomics

Dr Cordula Stover

  • Respiratory
  • Mediators of mucosal immunity
  • Microbial
  • Vascular inflammation in sepsis
  • Renal
  • Immune complex mediated inflammation

Professor Andy Wardlaw

  • Eosinophil biology, particularly as it relates to the pathogenesis of asthma
  • Drug development in asthma
  • Hypereosinophilic disease
  • Fungal diseases of the lung, in particular allergic fungal airway disease

Tuberculosis

Professor Mike Barer

  • Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis

Professor Andrea Cooper

  • Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
  • The role of early innate events in driving coordinated immune responses
  • The role of cytokines and chemokines in initiation, expression and regulation of immunity
  • The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
  • The role of the inflamed environment in regulating the expression of immunity

Dr Natalie Garton

  • Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
  • Spectroscopic methods to monitor bacterial adaptation

Dr Pranab Haldar

  • Epidemiology of latent and active tuberculosis

Dr Galina Mukamolova

  • Molecular mechanisms of bacterial dormancy and resuscitation
  • Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
  • Antimicrobial tolerance
  • Biomarkers of non-replicating persistence

Dr Helen O'Hare

  • Bacterial sensory perception and signal transduction
  • Regulation of bacterial metabolism (Mycobacterium tuberculosis)