Health Sciences

Professor Keith Abrams

• Development and Application of Bayesian Methods in Healthcare Evaluation
• Systematic Reviews and Meta-Analysis
• Joint Modelling of Longitudinal and Time-to-Event Data

Dr Sylwia Bujkiewicz

• Methods for multi-parameter evidence synthesis
• Bayesian methods in healthcare evaluation
• Bayesian evidence synthesis for surrogate endpoints evaluation
• Statistical methods in Health Technology Assessment

Professor Nicola Cooper

• Interface and Integration of Medical Statistics and Health Economics
• Methods for Statistical Modelling of Cost Data
• Integration of Evidence Synthesis within a Decision-Modelling Context
• Handling of Missing Data in Economic Evaluations Conducted Alongside Clinical Trials
• Application of Bayesian Statistical Methods to the above

Dr Michael Crowther

• The joint modelling of longitudinal and survival data
• Survival analysis, particularly parametric approaches to multi-state survival analysis
• Meta-analysis
• Statistical software development

Professor Laura Gray

• Design and Analysis of Randomised Clinical Trials (particularly cluster trials and those of complex interventions)
• Systematic Reviews and Meta-Analysis
• Prognostic model Development and Validation (see the Leicester Practice Risk Score)

Dr Paul Lambert

• Relative Survival Methods, in particular Modelling of Excess Mortality
• Meta-Analysis and Research Synthesis
• Hierarchical Models
• Use of Bayesian Methods in Medical Statistics
• Statistical Modelling of Cost Data and Cost Effectiveness Analysis

Dr Rupert Major

• Prognostic Model Development and Validation
• Clinical Implementation of Prognostic Models
• Application of Novel Biostatistical Models to Kidney Data   

Dr Mark Rutherford

• Methods for Analysing Population-Based Cancer Data
• Relative Survival Methods
• Modelling and Projecting Cancer Incidence

Professor Alex Sutton

• Meta-Analysis and Systematic Review Methods
• Multi-Parameter Evidence Synthesis Including Network Meta-Analysis
• Statistical Methods in Health Economics and Health Technology Assessment
• Graphical Methods For Displaying Statistical Information

Dr Michael Sweeting

• Joint modelling of longitudinal and time-to-event data
• Prognostic model development and validation
• Health economic decision modelling
• Design and analysis of randomised controlled trials
• Evidence synthesis and meta-analysis

Professor Melanie Davies, CBE

• Lifestyle and obesity management for diabetes prevention
• Management of diabetes and cardiovascular risk in South Asian populations
• Clinical trial design
• Lifestyle and physical activity interventions in the treatment of chronic disease
• Clinical trial design
• Complex interventions, including self-management and diabetes prevention
• Novel glucose lowering therapies
• Sedentary behaviour and health
• Novel therapies for obesity
• Type 2 diabetes mellitus in younger patients
• Diabetes screening

Dr Charlotte Edwardson

• Levels and patterns of physical activity and sedentary behaviour in different populations
• Effects of physical activity and sedentary behaviour on metabolic health and chronic disease
• Interventions to increase physical activity and reduce sedentary behaviour
• Objectively measured physical activity and sedentary behaviour
• Randomised controlled trials

Dr Clare Gillies

• Evidence synthesis and decision models for health research
• Economic evaluation of healthcare interventions
• Systematic Reviews and Meta-Analysis
• Prevention of diabetes and cardiovascular disease

Professor Laura Gray

• Design and Analysis of Randomised Clinical Trials (particularly cluster trials and those of complex interventions)
• Systematic Reviews and Meta-Analysis
• Prognostic model Development and Validation (see the Leicester Practice Risk Score)

Dr Deirdre Harrington

• Using physical activity to prevent chronic disease in children, adults and families.
• Design and evaluation of school and community based prevention programmes
• Understanding young people’s screen use
• Using screens to promote physical activity in young people
• Body composition assessment

Professor Kamlesh Khunti

• Epidemiological studies of diabetes and cardiovascular disease and early detection and screening for these diseases, in particular among South Asian people
• Interventional studies of prevention of type 2 diabetes and cardiovascular disease
• Models of delivering care for people with diabetes and cardiovascular disease
• Hypoglycaemia
• Therapeutic inertia

Dr Alex Rowlands

• Objective measurement of free-living physical behaviours (physical activity, sedentary behaviour and sleep)
• Analytical methods for the quantification of physical behaviours
• Effects of physical behaviours on health

Dr David Webb

• Continous Glucose Monitoring and hyperinsulinaemic – euglycaemic clamp systems
• Novel biomarkers in the prediction and management of Type 2 diabetes
• Insulin sensitivity measures and their therapeutic application in human diabetes research
• Epidemiology of screen-detected type 2 diabetes and early phase glucose dysregulation
• Novel vasculopathic mechanisms in Type 1 and Type 2 Diabetes mellitus

Dr Thomas Yates

• Effects of sedentary behaviour and different types of physical activity on metabolic health
• Treatment and prevention of type 2 diabetes and chronic disease by decreasing sedentary behaviour, and increasing standing, light movement and other movement-based therapies
• Physical activity epidemiology using regional, national and international datasets
• Translating physical activity and diabetes prevention programmes into routine practice

Professor Nuala Sheehan

• Methods for Inferring Causality from Observational Epidemiological Data
• Methods for Estimating Relationships from Genetic Marker Data
• Graphical Modelling of Complex Problems in Genetics
• Methods for Incorporating Pedigree Information in Genetic Analyses

Professor Frank Dudbridge

• Statistical Methods in Genetic Association Studies
• Prediction of Disease Risk from Genetic Data
• Mendelian Randomisation for Causal Inference in Epidemiology
• Integrative Analysis of Genetic, Epigenetic and –Omic Data
• Evolutionary Analysis of Malignant Tumour
• Genetic Epidemiology of Cardiovascular Disease, Breast Cancer, and Psychiatric Disorders

Dr Anna Guyatt

• Epidemiology of multimorbidity, particularly cardiorespiratory multimorbidity
• Genetic epidemiology of lung function and respiratory disease
• Mendelian randomisation for causal inference in epidemiology
• Development of longitudinal population cohort studies

Professor John Thompson

• Methods for the Meta-Analysis of Genetic Association Studies
• Methods for Estimating Phenotype-Disease Associations using Mendelian Randomisation
• Methods for Analysing Whole Genome Scans
• Methods for the Joint Analysis of ‘Omics Datasets

Professor Martin Tobin

• Investigation of the genetic determinants of common complex diseases and traits, including:
  • precision medicine
  • genome-wide studies of common and rare sequence variation
  • influence of copy number variation
  • lung function and respiratory disease
  • smoking cessation
  • cardiovascular disease and traits, particularly blood pressure
  • genomics in drug discovery, drug repositioning and stratified medicine
  • development and utilisation of new methods for the above studies

• Measurement (Psychopathology, Stressful Life Events, Social Networks, Autism in Adulthood)
• Social Support Networks
• Prevention of Depression
• Evaluation of Services for the Severely Mentally Ill
• Epidemiological Surveys of Mental Disorders including Autism Spectrum Disorders

• Comprehensive geriatric assessment
• Frailty
• Acute care
• Emergency care
• End of life care
• Mixed methods research

• Heart failure
• Multimorbidity
• Ageing
• Clinical epidemiology
• Clinical informatics
• Data science
• Healthcare systems

Professor Alice Smith (Kidney Lifestyle Research Group)

We are engaged in a translational pathway, spanning experimental research through to implementation, centred on the key aims of improving/maintaining physical function and enabling/encouraging regular physical activity in Chronic Kidney Disease (CKD).

Overall we hypothesise that our proposed translational pathway will:

• improve quality of life in CKD
• improve patient health outcomes in CKD
• reduce the healthcare and socio-economic cost burden of CKD

• activities of daily living, self-care and employment
• engagement in activities that are meaningful and important to the individual (hobbies, leisure activities, social activities)
• independent living
• ability to fulfil caring responsibilities for others eg spouse, parents, children
• metabolic and cardiovascular health
• cardiovascular events
• co-morbidities
• falls
• deterioration of renal function in those whose CKD is associated with poor metabolic and/or vascular health
• health and social care usage

• Older person’s care across primary, secondary, community and social care
• Health systems, workforce development, quality and safety in primary care
• Complex intervention studies and use of mixed methods
• Primary care approaches to global health

• Incontinence
• Women's health
• Qualitative research methods
• Mixed methods research

Dr Natalie Armstrong

• Healthcare improvement research, particularly drawing on social science theory and methods
• Population-based screening
• Women’s and children’s health
• Overdiagnosis, overtreatment, and overuse

Dr Helen Eborall

• Qualitative research methods
• Development and evaluation of complex interventions in healthcare
• Migration and healthcare
• Patient safety and quality improvement

Dr Nicola Mackintosh

• contribution of patients and families to safety, particularly regarding escalation of care for life threatening illness
• Service boundaries and their implications for patient journeys, safety and quality
• e-health technologies and telemedicine, and changing patient-provider relationships
• role of measurement in improvement and implementation science
• ethnographies of health care work

Dr Carolyn Tarrant

• Influences on staff and patient behaviours related to prevention of healthcare associated infections and optimisation of antibiotic use
• Patient experience of quality and safety in healthcare
• Theory-based intervention development & evaluation
• Qualitative Research; ethnography

Professor Liz Draper

• Data harmonisation and standardisation for preterm birth cohorts – both national and international
• Outcomes from neonatal and paediatric intensive care
• Surveillance and confidential enquiries into perinatal mortality and morbidity

Professor Samantha Johnson

• Developmental psychology and psychopathology
• Assessing neurodevelopmental outcomes in childhood
• Long term neurodevelopmental outcomes after high risk birth
• Educational outcomes after high risk birth

Dr Lucy Smith

• Statistical methodology around the measurement and monitoring of adverse pregnancy outcomes
• Qualitative research to understand parents’ and clinicians’ experiences of pregnancy loss, neonatal mortality and preterm birth
• Use of large-scale routine health data to monitor and reduce inequalities in health

Professor Douglas Tincello

• Clinical Trial Interventions in Women’s Health - particularly Continence Care and Pelvic Floor Dysfunction
• Qualitative Research Methodology
• Reproductive Epidemiology
• Clinical Trial Methodology - including Complex Interventions

Dr Brad Manktelow

• The use of quantitative data for quality improvement in healthcare
• Statistical process control (SPC) methodology applied to healthcare
• Statistical methods for the routine reporting of healthcare quality indicators
• The selection of quality indicators for quality assurance and quality improvement in healthcare

Dr Elaine Boyle

• Effects of gestational age at birth on neonatal and later outcomes
• Late preterm and early term birth
• Assessment and management of neonatal pain
• Enteral feeding in preterm infants
• Neonatal randomised controlled trials