Population Health Sciences
Biostatistics
Dr Rebecca Baggaley
- Infectious Disease Epidemiology
- Infection Transmission Mathematical Modelling
- Economic Evaluations, in particular Decision Analytic and Markov Modelling
- Measuring Wider Impacts of COVID-19 Interventions
- Infectious Disease Screening Strategies for Hard-to-Reach Populations
Dr Sarah Booth
- Survival analysis and competing risks
- Methodology for developing, validating and updating prognostic models
- Analysis of population-based cancer registry data
- Methods for Multi-parameter Evidence Synthesis
- Bayesian Methods in Healthcare Evaluation
- Bayesian Evidence Synthesis for Surrogate Endpoints Evaluation
- Statistical Methods in Health Technology Assessment
- Interface and Integration of Medical Statistics and Health Economics
- Methods for Statistical Modelling of Cost Data
- Integration of Evidence Synthesis within a Decision-Modelling Context
- Handling of Missing Data in Economic Evaluations Conducted Alongside Clinical Trials
- Application of Bayesian Statistical Methods to the above
- Multi-parameter Evidence Synthesis includng Network Meta-Analysis and Component Network Meta-Analysis
- Evidence Synthesis of Time-To-Event Outcomes
- Individual Participant Data Meta-Analysis and Network Meta-Analysis
- Bayesian Evidence Synthesis
- Design and Analysis of Clinical Trials (particularly cluster and stepped wedge trials and those testing complex interventions)
- Systematic Reviews and Meta-Analysis
- Prognostic Model Development and Validation
- Statistical Methods for Systematic Reviews and Meta-analysis
- Meta-Analysis and Network Meta-Analysis of Complex Multi-Component Interventions
- Evidence Synthesis of Public Health Interventions
- Relative Survival Methods, in particular Modelling of Excess Mortality
- Casual Inference Methods
- Epidemiological Design
Dr Tim Lucas
- Environmental epidemiology
- Machine learning
- Global health
- Spatial statistics
- Methods for Analysing Population-Based Registry Data
- Relative Survival Methods and Competing Risks Methodology
- Modelling and Projecting Cancer Incidence
- Prognostic Model Development and Validation
- Approaches for Extrapolating Survival Curves
- Meta-Analysis and Systematic Review Methods
- Multi-Parameter Evidence Synthesis Including Network Meta-Analysis
- Statistical Methods in Health Economics and Health Technology Assessment
- Graphical Methods For Displaying Statistical Information
Dr Lucy Teece
- Health inequalities and improving research generalisability
- COVID-19 and long-COVID related research
- Prognosis research including prognostic model development and validation
- Survival analysis methods including competing risks
Diabetes Research Centre
Dr Ffion Curtis
- Lifestyle interventions in community and clinical settings
- Prevention and management of chronic conditions such as diabetes and multimorbidity
- Systematic reviews of quantitative and qualitative studies
- Lifestyle and obesity management for diabetes prevention and management
- Management of diabetes and cardiovascular risk in South Asian populations
- Clinical trial design
- Lifestyle and physical activity interventions in the treatment of chronic disease
- Clinical trial design
- Complex interventions, including self-management and diabetes prevention
- Novel glucose lowering therapies
- Sedentary behaviour and health
- Novel therapies for obesity
- Type 2 diabetes mellitus in younger patients
- Diabetes screening
- Type 2 Diabetes
- Levels and patterns of physical activity and sedentary behaviour in different populations
- Effects of physical activity and sedentary behaviour on metabolic health and chronic disease
- Interventions to increase physical activity and reduce sedentary behaviour
- Objectively measured physical activity and sedentary behaviour
- Randomised controlled trials
- Use of real world data for health research
- Evidence synthesis and decision models for health research
- Systematic Reviews and Meta-Analysis
- Prevention of diabetes and cardiovascular disease
Dr Pankaj Gupta
- Non -Adherence to medications: Its diagnosis and management using novel chemical adherence testing by LC-MS/MS
- Study of Renin angiotensin aldosterone axis and its counter regulation
- Resistant Hypertension: Causes and Management
- Biofeedback to manage patients with multiple medication intolerances
- Behaviour change
- Qualitative research methods (exploratory, evaluation)
- Theory-based intervention development (including behavioural lifestyle self-management interventions, diabetes prevention)
- Digital-based interventions
- Long-term conditions and Multi-morbidity (i.e. type 2 diabetes, type 1 diabetes)
- Patient-reported outcome measures
- Epidemiological studies of diabetes and cardiovascular disease and early detection and screening for these diseases, in particular among South Asian people
- Interventional studies of prevention and management of people with of type 2 diabetes and cardiovascular disease
- Models of delivering care for people with diabetes and cardiovascular disease
- Hypoglycaemia
- Therapeutic inertia
- Multimorbidity
- Covid-19 related research
- Systematic Reviews and Meta-Analysis
- Management of older people with diabetes and cardiometabolic multimorbidity
- Epidemiological studies of diabetes and cardiovascular disease
- Interventional studies of prevention of type 2 diabetes and cardiovascular disease
- Models of delivering care for people with diabetes and cardiovascular disease
- Therapeutic inertia
- Accelerometer measurement of free-living physical behaviours (physical activity, sedentary behaviour and sleep)
- Analytical methods for the quantification of physical behaviours
- Effects of physical behaviours on health
- Continous Glucose Monitoring and hyperinsulinaemic – euglycaemic clamp systems
- Novel biomarkers in the prediction and management of Type 2 diabetes
- Insulin sensitivity measures and their therapeutic application in human diabetes research
- Epidemiology of screen-detected type 2 diabetes and early phase glucose dysregulation
- Novel vasculopathic mechanisms in Type 1 and Type 2 Diabetes mellitus
- Applied health research
- Lifestyle (including dietary, exercise, and physical activity) interventions in the treatment of chronic disease, in particular chronic kidney disease and those living with multimorbidity
- Sarcopenia and frailty in those living with chronic diseases
- Evaluation of clinimetric properties of patient reported outcome measures (PROMs)
- Effects of sedentary behaviour and different types of physical activity on metabolic health
- Treatment and prevention of type 2 diabetes and chronic disease by decreasing sedentary behaviour, and increasing light movement, walking or more intensive movement-based therapies
- Interaction between mediation and lifestyle therapies (diet and exercise) for weight loss and diabetes management
- Physical activity and obesity epidemiology using regional, national and international datasets
- Translating physical activity and diabetes prevention programmes into routine practice
- Use of large electronic health record datasets for epidemiological investigations
- Statistical models for etiological, demographic, and prognostic research
- Use of alternative risk metrics for clinical interpretation of RCTs
- Comparative-effectiveness pharmacoepidemiological studies
- Evidence-based medicine and clinical guidelines
Genetic Epidemiology
- Investigating genetic determinants of fibrotic diseases, particularly pulmonary fibrosis
- Genome-wide association studies of pulmonary fibrosis risk and disease progression
- Subtyping pulmonary fibrosis
- Genetics of fibrotic multimorbidity
- Statistical Methods in Genetic Association Studies
- Prediction of Disease Risk from Genetic Data
- Mendelian Randomisation for Causal Inference in Epidemiology
- Integrative Analysis of Genetic, Epigenetic and –Omic Data
- Evolutionary Analysis of Malignant Tumour
- Genetic Epidemiology of Cardiovascular Disease, Breast Cancer, and Psychiatric Disorders
- Epidemiology of multimorbidity, particularly cardiorespiratory multimorbidity
- Genetic epidemiology of lung function and respiratory disease
- Mendelian randomisation for causal inference in epidemiology
- Development of longitudinal population cohort studies
- Predictors of occupational wellbeing in healthcare workers
- Investigation of the genetic determinants of common complex diseases and traits, including:
- precision medicine
- genome-wide studies of common and rare sequence variation
- influence of copy number variation
- lung function and respiratory disease
- smoking cessation
- cardiovascular disease and traits, particularly blood pressure
- genomics in drug discovery, drug repositioning and stratified medicine
- development and utilisation of new methods for the above studies
Healthcare
Professor Debi Bhattacharya
My research programmes focus on applying behavioural science to medicines optimisation challenges and intervention implementation. Recent studies include:
- Developing and validating scales to identify the determinants and magnitude of medication adherence for people prescribed multiple medicines
-
Developing deprescribing interventions for dependence forming medication and polypharmacy in older people
-
Developing a theory and evidence informed framework of dissemination
Professor David Wright
- Medicines optimisation for older people in care homes
- Medicines administration for people with dysphagia
- Integration of community pharmacy services within primary care
Dr Sion Scott
- Application of behavioural science to design and evaluate interventions targeting practitioner and patient behaviour
- Deprescribing for older people in the hospital setting
- Addressing barriers to medication adherence
Mental Health, Ageing, Public Health and Primary Care (MAPP)
- Measurement (Psychopathology, Stressful Life Events, Social Networks, Autism in Adulthood)
- Social Support Networks
- Prevention of Depression
- Evaluation of Services for the Severely Mentally Ill
- Epidemiological Surveys of Mental Disorders including Autism Spectrum Disorders
- Heart failure
- Multimorbidity
- Ageing
- Clinical epidemiology
- Clinical informatics
- Data science
- Healthcare systems
Professor Alice Smith (Kidney Lifestyle Research Group)
We are engaged in a translational pathway, spanning experimental research through to implementation, centred on the key aims of improving/maintaining physical function and enabling/encouraging regular physical activity in Chronic Kidney Disease (CKD).
Overall we hypothesise that our proposed translational pathway will:
- improve quality of life in CKD
- improve patient health outcomes in CKD
- reduce the healthcare and socio-economic cost burden of CKD
via impact on:
- activities of daily living, self-care and employment
- engagement in activities that are meaningful and important to the individual (hobbies, leisure activities, social activities)
- independent living
- ability to fulfil caring responsibilities for others eg spouse, parents, children
- metabolic and cardiovascular health
- cardiovascular events
- co-morbidities
- falls
- deterioration of renal function in those whose CKD is associated with poor metabolic and/or vascular health
- health and social care usage
- Older person’s care across primary, secondary, community and social care
- Health systems, workforce development, quality and safety in primary care
- Complex intervention studies and use of mixed methods
- Primary care approaches to global health
Dr Kate Williams
- Incontinence
- Women's health
- Qualitative research methods
- Mixed methods research
Social Science Applied to Health Improvement Research (SAPPHIRE)
- Healthcare improvement research, particularly drawing on social science theory and methods
- Population-based screening
- Women’s and children’s health
- Overdiagnosis, overtreatment, and overuse
Dr Jennifer Creese
- Healthcare workforce and human resources for health
- Healthcare organisational culture and practice
- Migrant and minority health experiences
- Qualitative research; ethnography
Dr Kate Kirk
- Healthcare workforce and wellbeing; emotion, work and regulation
- Quality, safety and risk, knowledge translation and evidence based practice
- Emergency and urgent care
- Qualitative research and ethnography
- contribution of patients and families to safety, particularly regarding escalation of care for life threatening illness
- Service boundaries and their implications for patient journeys, safety and quality
- e-health technologies and telemedicine, and changing patient-provider relationships
- role of measurement in improvement and implementation science
- ethnographies of health care work
- Use of mix methods to curate learning from patient safety incidents
- Organisational responses following adverse events in healthcare
- Applying high reliability theory to healthcare practice
- Safety in Gastrointestinal endoscopy
- Barrett's oesophagus screening
- Influences on staff and patient behaviours related to prevention of healthcare associated infections and optimisation of antibiotic use
- Patient experience of quality and safety in healthcare
- Theory-based intervention development & evaluation
- Qualitative Research; ethnography
The Infant Mortality and Morbidity Studies (TIMMS)
- Data harmonisation and standardisation for preterm birth cohorts – both national and international
- Outcomes from neonatal and paediatric intensive care
- Surveillance and confidential enquiries into perinatal mortality and morbidity
- Developmental psychology and psychopathology
- Assessing neurodevelopmental outcomes in childhood
- Long term neurodevelopmental outcomes after high risk birth
- Educational outcomes after high risk birth
- Statistical methodology around the measurement and monitoring of adverse pregnancy outcomes
- Qualitative research to understand parents’ and clinicians’ experiences of pregnancy loss, neonatal mortality and preterm birth
- Use of large-scale routine health data to monitor and reduce inequalities in health
- The use of quantitative data for quality improvement in healthcare
- Statistical process control (SPC) methodology applied to healthcare
- Statistical methods for the routine reporting of healthcare quality indicators
- The selection of quality indicators for quality assurance and quality improvement in healthcare
Professor Elaine Boyle
- Effects of gestational age at birth on neonatal and later outcomes
- Late preterm and early term birth
- Assessment and management of neonatal pain
- Enteral feeding in preterm infants
- Neonatal randomised controlled trials
Dr Sarah Seaton
- Epidemiology, experiences and outcomes following neonatal and/or paediatric intensive care
- Outcomes and experiences following transport by paediatric critical care teams
- Supporting parents and families who have or had a critically ill child