Health Sciences

Biostatistics

Professor Keith Abrams

  • Development and Application of Bayesian Methods in Healthcare Evaluation
  • Systematic Reviews and Meta-Analysis
  • Joint Modelling of Longitudinal and Time-to-Event Data

Dr Sylwia Bujkiewicz

  • Methods for multi-parameter evidence synthesis
  • Bayesian methods in healthcare evaluation
  • Bayesian evidence synthesis for surrogate endpoints evaluation
  • Statistical methods in Health Technology Assessment

Professor Nicola Cooper

  • Interface and Integration of Medical Statistics and Health Economics
  • Methods for Statistical Modelling of Cost Data
  • Integration of Evidence Synthesis within a Decision-Modelling Context
  • Handling of Missing Data in Economic Evaluations Conducted Alongside Clinical Trials
  • Application of Bayesian Statistical Methods to the above

Dr Michael Crowther

  • The joint modelling of longitudinal and survival data
  • Survival analysis, particularly parametric approaches to multi-state survival analysis
  • Meta-analysis
  • Statistical software development

Professor Laura Gray

  • Design and Analysis of Randomised Clinical Trials (particularly cluster trials and those of complex interventions)
  • Systematic Reviews and Meta-Analysis
  • Prognostic model Development and Validation (see the Leicester Practice Risk Score)

Dr Paul Lambert

  • Relative Survival Methods, in particular Modelling of Excess Mortality
  • Meta-Analysis and Research Synthesis
  • Hierarchical Models
  • Use of Bayesian Methods in Medical Statistics
  • Statistical Modelling of Cost Data and Cost Effectiveness Analysis

Dr Rupert Major

  • Prognostic Model Development and Validation
  • Clinical Implementation of Prognostic Models
  • Application of Novel Biostatistical Models to Kidney Data   

Dr Mark Rutherford

  • Methods for Analysing Population-Based Cancer Data
  • Relative Survival Methods
  • Modelling and Projecting Cancer Incidence

Professor Alex Sutton

  • Meta-Analysis and Systematic Review Methods
  • Multi-Parameter Evidence Synthesis Including Network Meta-Analysis
  • Statistical Methods in Health Economics and Health Technology Assessment
  • Graphical Methods For Displaying Statistical Information

Dr Michael Sweeting

  • Joint modelling of longitudinal and time-to-event data
  • Prognostic model development and validation
  • Health economic decision modelling
  • Design and analysis of randomised controlled trials
  • Evidence synthesis and meta-analysis

Diabetes Research Centre

Professor Melanie Davies, CBE

  • Lifestyle and obesity management for diabetes prevention
  • Management of diabetes and cardiovascular risk in South Asian populations
  • Clinical trial design
  • Lifestyle and physical activity interventions in the treatment of chronic disease
  • Clinical trial design
  • Complex interventions, including self-management and diabetes prevention
  • Novel glucose lowering therapies
  • Sedentary behaviour and health
  • Novel therapies for obesity
  • Type 2 diabetes mellitus in younger patients
  • Diabetes screening

Dr Charlotte Edwardson

  • Levels and patterns of physical activity and sedentary behaviour in different populations
  • Effects of physical activity and sedentary behaviour on metabolic health and chronic disease
  • Interventions to increase physical activity and reduce sedentary behaviour
  • Objectively measured physical activity and sedentary behaviour
  • Randomised controlled trials

Dr Clare Gillies

  • Evidence synthesis and decision models for health research
  • Economic evaluation of healthcare interventions
  • Systematic Reviews and Meta-Analysis
  • Prevention of diabetes and cardiovascular disease

Professor Laura Gray

  • Design and Analysis of Randomised Clinical Trials (particularly cluster trials and those of complex interventions)
  • Systematic Reviews and Meta-Analysis
  • Prognostic model Development and Validation (see the Leicester Practice Risk Score)

Dr Deirdre Harrington

  • Using physical activity to prevent chronic disease in children, adults and families.
  • Design and evaluation of school and community based prevention programmes
  • Understanding young people’s screen use
  • Using screens to promote physical activity in young people
  • Body composition assessment

Professor Kamlesh Khunti

  • Epidemiological studies of diabetes and cardiovascular disease and early detection and screening for these diseases, in particular among South Asian people
  • Interventional studies of prevention of type 2 diabetes and cardiovascular disease
  • Models of delivering care for people with diabetes and cardiovascular disease
  • Hypoglycaemia
  • Therapeutic inertia

Dr Alex Rowlands

  • Objective measurement of free-living physical behaviours (physical activity, sedentary behaviour and sleep)
  • Analytical methods for the quantification of physical behaviours
  • Effects of physical behaviours on health

Dr David Webb

  • Continous Glucose Monitoring and hyperinsulinaemic – euglycaemic clamp systems
  • Novel biomarkers in the prediction and management of Type 2 diabetes
  • Insulin sensitivity measures and their therapeutic application in human diabetes research
  • Epidemiology of screen-detected type 2 diabetes and early phase glucose dysregulation
  • Novel vasculopathic mechanisms in Type 1 and Type 2 Diabetes mellitus

Dr Thomas Yates

  • Effects of sedentary behaviour and different types of physical activity on metabolic health
  • Treatment and prevention of type 2 diabetes and chronic disease by decreasing sedentary behaviour, and increasing standing, light movement and other movement-based therapies
  • Physical activity epidemiology using regional, national and international datasets
  • Translating physical activity and diabetes prevention programmes into routine practice

Genetic Epidemiology

Professor Nuala Sheehan

  • Methods for Inferring Causality from Observational Epidemiological Data
  • Methods for Estimating Relationships from Genetic Marker Data
  • Graphical Modelling of Complex Problems in Genetics
  • Methods for Incorporating Pedigree Information in Genetic Analyses

Professor Frank Dudbridge

  • Statistical Methods in Genetic Association Studies
  • Prediction of Disease Risk from Genetic Data
  • Mendelian Randomisation for Causal Inference in Epidemiology
  • Integrative Analysis of Genetic, Epigenetic and –Omic Data
  • Evolutionary Analysis of Malignant Tumour
  • Genetic Epidemiology of Cardiovascular Disease, Breast Cancer, and Psychiatric Disorders

Professor John Thompson

  • Methods for the Meta-Analysis of Genetic Association Studies
  • Methods for Estimating Phenotype-Disease Associations using Mendelian Randomisation
  • Methods for Analysing Whole Genome Scans
  • Methods for the Joint Analysis of ‘Omics Datasets

Professor Martin Tobin

  • Investigation of the genetic determinants of common complex diseases and traits, including:
    • precision medicine
    • genome-wide studies of common and rare sequence variation
    • influence of copy number variation
    • lung function and respiratory disease
    • smoking cessation
    • cardiovascular disease and traits, particularly blood pressure
    • genomics in drug discovery, drug repositioning and stratified medicine
    • development and utilisation of new methods for the above studies

Mental Health, Ageing, Public Health and Primary Care (MAPP)

Professor Terry Brugha
  • Measurement (Psychopathology, Stressful Life Events, Social Networks, Autism in Adulthood)
  • Social Support Networks
  • Prevention of Depression
  • Evaluation of Services for the Severely Mentally Ill
  • Epidemiological Surveys of Mental Disorders including Autism Spectrum Disorders
Professor Simon Conroy
  • Comprehensive geriatric assessment
  • Frailty
  • Acute care
  • Emergency care
  • End of life care
  • Mixed methods research
Professor Umesh Kadam
  • Heart failure
  • Multimorbidity
  • Ageing
  • Clinical epidemiology
  • Clinical informatics
  • Data science
  • Healthcare systems

Professor Alice Smith (Kidney Lifestyle Research Group)

We are engaged in a translational pathway, spanning experimental research through to implementation, centred on the key aims of improving/maintaining physical function and enabling/encouraging regular physical activity in Chronic Kidney Disease (CKD).

Overall we hypothesise that our proposed translational pathway will:

  • improve quality of life in CKD
  • improve patient health outcomes in CKD
  • reduce the healthcare and socio-economic cost burden of CKD
via impact on:
  • activities of daily living, self-care and employment
  • engagement in activities that are meaningful and important to the individual (hobbies, leisure activities, social activities)
  • independent living
  • ability to fulfil caring responsibilities for others eg spouse, parents, children
  • metabolic and cardiovascular health
  • cardiovascular events
  • co-morbidities
  • falls
  • deterioration of renal function in those whose CKD is associated with poor metabolic and/or vascular health
  • health and social care usage
Dr Chris Williams  cdw4@le.ac.uk
  • Older person’s care across primary, secondary, community and social care
  • Health systems, workforce development, quality and safety in primary care
  • Complex intervention studies and use of mixed methods
  • Primary care approaches to global health
Dr Kate Williams
  • Incontinence
  • Women's health
  • Qualitative research methods
  • Mixed methods research

Social Science Applied to Health Improvement Research (SAPPHIRE)

Dr Natalie Armstrong

  • Healthcare improvement research, particularly drawing on social science theory and methods
  • Population-based screening
  • Women’s and children’s health
  • Overdiagnosis, overtreatment, and overuse

Dr Helen Eborall

  • Qualitative research methods
  • Development and evaluation of complex interventions in healthcare
  • Migration and healthcare
  • Patient safety and quality improvement

Dr Nicola Mackintosh

  • contribution of patients and families to safety, particularly regarding escalation of care for life threatening illness
  • Service boundaries and their implications for patient journeys, safety and quality
  • e-health technologies and telemedicine, and changing patient-provider relationships
  • role of measurement in improvement and implementation science
  • ethnographies of health care work

Dr Carolyn Tarrant

  • Influences on staff and patient behaviours related to prevention of healthcare associated infections and optimisation of antibiotic use
  • Patient experience of quality and safety in healthcare
  • Theory-based intervention development & evaluation
  • Qualitative Research; ethnography

The Infant Mortality and Morbidity Studies (TIMMS)

Professor Liz Draper

  • Data harmonisation and standardisation for preterm birth cohorts – both national and international
  • Outcomes from neonatal and paediatric intensive care
  • Surveillance and confidential enquiries into perinatal mortality and morbidity

Professor Samantha Johnson

  • Developmental psychology and psychopathology
  • Assessing neurodevelopmental outcomes in childhood
  • Long term neurodevelopmental outcomes after high risk birth
  • Educational outcomes after high risk birth

Dr Lucy Smith

  • Statistical methodology around the measurement and monitoring of adverse pregnancy outcomes
  • Qualitative research to understand parents’ and clinicians’ experiences of pregnancy loss, neonatal mortality and preterm birth
  • Use of large-scale routine health data to monitor and reduce inequalities in health

Professor Douglas Tincello

  • Clinical Trial Interventions in Women’s Health - particularly Continence Care and Pelvic Floor Dysfunction
  • Qualitative Research Methodology
  • Reproductive Epidemiology
  • Clinical Trial Methodology - including Complex Interventions

Dr Brad Manktelow

  • The use of quantitative data for quality improvement in healthcare
  • Statistical process control (SPC) methodology applied to healthcare
  • Statistical methods for the routine reporting of healthcare quality indicators
  • The selection of quality indicators for quality assurance and quality improvement in healthcare

Dr Elaine Boyle

  • Effects of gestational age at birth on neonatal and later outcomes
  • Late preterm and early term birth
  • Assessment and management of neonatal pain
  • Enteral feeding in preterm infants
  • Neonatal randomised controlled trials