People

Dr Clare Gillies

Associate Professor in Medical Statistics

Profile

I am part of the Leicester Real World Evidence Unit based at the Leicester Diabetes Centre, primarily using complex real world datasets such as the Clinical Practice Research Datalink to address health research questions. I specialise in decision modelling, evidence synthesis, and cost-effectiveness analyses.

Research

I currently work on projects funded by NIHR (two programme grants) HDR-UK, and industry collaborators including Novo Nordisk, Sanofi, and Boehringer Ingelheim.

Publications

(0) Gillies CL, Rowlands AV, Razieh C, Nafilyan V, Chudasama Y, Islam N, Zaccardi F, Ayoubkhani D, Lawson C, Davies MJ, Yates T, Khunti K. Association between household size and COVID-19: A UK Biobank observational study. J R Soc Med. 2022 Feb. doi: 10.1177/01410768211073923.

Danielli, M.; Gillies, C.; Thomas, R.C.; Melford, S.E.; Baker, P.N.; Yates, T.; Khunti, K.; Tan, B.K. Effects of Supervised Exercise on the Development of Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis. J. Clin. Med. 2022, 11, 793. https://doi.org/10.3390/jcm11030793

Seidu S, Gillies C, Zaccardi F, Kunutsor S, Hartmann-Boyce J, Yates T Singh A, Davies M, Khunti K. The impact of obesity on severe disease and mortality in people with SARS-CoV-2: A systematic review and meta-analysis. Endocrinol Diab Metab. 2021; 4:e00176. https://doi.org/10.1002/edm2.176

Farooqi A, Gillies C, Sathanapally H, Abner S, Seidu S, Davies MJ, Polonsky WH, Khunti K. A systematic review and meta-analysis to compare the prevalence of depression between people with and without Type 1 and Type 2 diabetes. Prim Care Diabetes. 2022 Feb;16(1):1-10. doi: 10.1016/j.pcd.2021.11.001.

Rowlands AV, Dempsey PC, Gillies C, Kloecker DE, Razieh C, Chudasama Y, Islam N, Zaccardi F, Lawson C, Norris T, Davies MJ, Khunti K, Yates T. Association Between Accelerometer-Assessed Physical Activity and Severity of COVID-19 in UK Biobank. Mayo Clin Proc Innov Qual Outcomes. 2021 Dec;5(6):997-1007. doi: 10.1016/j.mayocpiqo.2021.08.011.

Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., Khunti, K. (2021). Obesity, ethnicity and risk of critical care, mechanical ventilation and mortality in patients admitted to hospital with COVID-19: Analysis of the ISARIC CCP-UK cohort. Obesity, 29(7), 1223-1230. doi:10.1002/oby.23178

Chudasama, Y. V., Zaccardi, F., Coles, B., Gillies, C. L., Hvid, C., Seidu, S., Khunti, K. (n.d.). Ethnic, social and multimorbidity disparities in therapeutic inertia: a UK primary care observational study in patients newly diagnosed with type 2 diabetes. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. doi:10.1111/dom.14482

Rowlands, A.V., Gillies, C., Chudasama, Y., et al. Association of working shifts, inside and outside of healthcare, with severe COVID−19: an observational study. BMC Public Health 21, 773 (2021). https://doi.org/10.1186/s12889-021-10839-0

Hu J, Gillies CL, Lin S, Stewart ZA, Melford SE, Abrams KR, et al. Association of maternal lipid profile and gestational diabetes mellitus: A systematic review and meta-analysis of 292 studies and 97,880 women. EClinicalMedicine. 2021;34:100830.

Razieh C, Zaccardi F, Islam N, Gillies CL, V Chudasama Y, Rowlands A, et al. Ethnic minorities and COVID-19: examining whether excess risk is mediated through deprivation. European Journal of Public Health. 2021

Coles B, Zaccardi F, Seidu S, Gillies CL, Davies MJ, Hvid C, Khunti K. Rates and estimated cost of primary care consultations in people diagnosed with type 2 diabetes and comorbidities: A retrospective analysis of 8.9 million consultations. Diabetes Obes Metab. 2021 Jun;23(6):1301-1310. doi: 10.1111/dom.14340. Epub 2021 Feb 19. PMID: 33539642.

Chudasama YV, Khunti K, Gillies CL, Dhalwani NN, Davies MJ, Yates T, Zaccardi F. Healthy Lifestyle and Life Expectancy in people with Multimorbidity: a UK Biobank prospective study. Plos Medicine, Sept 2020. doi.org/10.1371/journal.pmed.1003332 

Seidu S, Gillies C, Farooqi A, Trivedi H, Brady E, Davies MJ, Khunti K. A cost comparison of an enhanced primary care diabetes service and standard care. Primary care Diabetes 2020 Dec. Doi: 10.1016/j.pcd.2020.10.011. PMID: 33279438

Singh AK, Gillies CL*, Singh R, et al. Prevalence of co-morbidities and their association with mortality in patients with COVID-19: A systematic review and meta-analysis [published online ahead of print, 2020 Jun 23]. Diabetes Obes Metab. 2020;10.1111/dom.14124. (*joint first author)

Usman M, Khunti K, Davies MJ, Gillies CL. Association and relative importance of multiple risk factor control on cardiovascular disease, end-stage renal disease and mortality in people with type 2 diabetes: a population-based retrospective cohort study.  2020 Primary Care Diabetes. doi.org/10.1016/j.pcd.2020.08.008

Fitzpatrick C, Gillies C*, Seidu S, Kar D, Ioannidou E, Patel P, Gupta P, Davies M, Khunti K. 
Effect of pragmatic versus explanatory interventions on medication adherence in people with cardiometabolic conditions: a systematic review and meta-analysis. BMJ Open 2020;10:e036575. doi: 10.1136/bmjopen-2019-036575. (*joint first author)

Vounzoulaki E, Khunti K, Abner S, Tan BK, Davies MJ, Gillies C L. Progression to type 2 diabetes in women with a known history of gestational diabetes: A systematic review and meta-analysis.   BMJ. 2020; 369: m1361. Published online 2020 May 13. doi: 10.1136/bmj.m1361

Usman M, Khunti K, Davies M, Gillies CL. Cost-effectiveness of intensive interventions compared to standard care in individuals with type 2 diabetes: A systematic review and critical appraisal of decision-analytic models. Diabetes Res Clin Pract. 2020 Feb 12; 161:108073. doi: 10.1016/j.diabres.2020.108073.

Chudasama YV, Khunti K, Zaccardi F, Rowlands AV, Yates T, Gillies CL, Davies MJ, Dhalwani NN. Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study. BMC Medicine 2019 17:108 

Gillies CL, Lambert PC,  Abrams KR, Sutton AJ, Cooper NJ, Hsu R, Davies M, Khunti K. A cost-effectiveness analysis for different strategies for the screening and prevention of type 2 diabetes mellitus. British Medical Journal, 2008, 336: 1180-1185.*

Gillies CL, Abrams KR, Lambert PC, Cooper NJ, Sutton AJ, Hsu R, Khunti K. Pharmacological and Lifestyle Interventions to Prevent or Delay Type 2 Diabetes Mellitus in Individuals with Impaired Glucose Tolerance: A Systematic Review and Meta-analysis.   British Medical Journal, 2007; 334: 299.
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Supervision

Elizabeth Hickman (current). Medication de-prescribing in elder people with diabetes.  

Meri Everitt (current). Evaluation and development of methodologies for using real world evidence to investigate the results of randomised controlled trials, utilising COVID-19 vaccine trials as a worked example.  

Shukrat Olatunji (current). Impact of COVID-19 in patients with Multimorbidity using real-world data.  

James Schmidt (current). Statistical Methods for Survival Analysis in Large-scale Electronic Health Records.  

Elpida Voulounzaki (current). Type 2 diabetes in women after a diagnosis of gestational diabetes: understanding uptake to screening, progression rates and costs, using evidence synthesis methodologies

Zoe Morgan (current). The association between attention deficit hyperactivity disorder with autism spectrum disorder and other psychiatric conditions, in the adult general population.

Janharpret Singh (current). Investigating methods of incorporating real world data in health technology assessment decision-making: application in rheumatoid arthritis.

Yogini Chudasama (completed). Multimorbidity and mortality: Role of physical activity and other lifestyle behaviours.

Usman Muhammad (completed). The clinical and cost-effectiveness of intensive multifactorial interventions compared to standard care in individuals with type 2 diabetes mellitus and microalbuminuria

Teaching

I lead the PASS2 module (population and social sciences 2) delivered to Medical students in their first year, which covers an introduction to epidemiology and medical statistics. I am also deputy lead for the Quantitative Methods module on the MRes in Applied Health Research.
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