Dr Lauren O'Mahoney

Dr Lauren O’Mahoney is a Research Fellow at the University of Leicester within the Leicester Lifestyle and Health Research Group. Her work focuses on how lifestyle factors influence cardiometabolic health, particularly in people living with obesity, diabetes, and related chronic conditions.

She completed her PhD in diabetes, nutrition, and cardiovascular health, and has since developed expertise in clinical trials, epidemiology, and evidence synthesis. Her research centres on the design and evaluation of lifestyle-based interventions to improve health outcomes.

She has contributed to large-scale collaborative research investigating the long-term health impacts of COVID-19 and is actively involved in interdisciplinary research within the Leicester Diabetes Centre.

Dr Lauren O’Mahoney’s research examines how lifestyle factors influence cardiometabolic health, particularly in people living with obesity, diabetes, and related chronic conditions.

Her work spans clinical trials, epidemiology, and evidence synthesis, with a focus on the design and evaluation of lifestyle-based interventions. She has contributed to research on glycaemic control, vascular function, and the broader impacts of long-term conditions, including investigating the long-term effects of COVID-19.

Her research aims to generate evidence that supports practical, scalable approaches to improving health outcomes, alongside an interest in the biological mechanisms underpinning cardiometabolic health and disease.

Research Interests

• Cardiometabolic health
• Obesity and diabetes (type 1 and type 2)
• Lifestyle and environmental exposures
• Glycaemic control and metabolic regulation
• Vascular physiology
• Systems-level and mechanistic approaches to health and disease

h-index: 18  |  i10-index: 21

A full list of publications is available on Google Scholar: https://scholar.google.com/citations?user=zZtERs4AAAAJ&hl=en

Selected peer-reviewed journal articles: 

Sidki AS, Highton PJ, O’Mahoney LL, Wilkinson TJ. Hybrid closed-loop insulin delivery improves glycaemic control compared with sensor-augmented pump therapy: a meta-analysis of ‘free-living’ randomised trials in type 1 diabetes. Diabetic Medicine. 2026:e70210.

Funnell MP, Routen A, O’Mahoney LL, Ikhile D, Khunti K, Highton PJ. Clarity in reporting multiple long-term conditions in research: the need for consistency and consensus. Diabetes, Obesity and Metabolism. 2026.

O’Mahoney LL, Routen A, Gillies C, Jenkins SA, Almaqhawi A, Ayoubkhani D, et al. The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies. Nature Communications. 2025;16:4249.

O’Mahoney LL, Highton PJ, Abdala R, Dallosso H, Gillies CL, Ragha S, et al. Deintensification of potentially inappropriate medications amongst older frail people with type 2 diabetes: a cluster randomised controlled trial protocol (D-MED study). Primary Care Diabetes. 2024;18(2):132–137.

Ekezie W, Cassambai S, Czyznikowska B, Curtis F, O’Mahoney LL, Willis A, Chudasama Y, Khunti K, Farooqi A. Health and social care experience and research perception of different ethnic minority populations in the East Midlands, United Kingdom (REPRESENT study). Health Expectations. 2024;27(1):e13944.

O’Mahoney LL, Routen A, Gillies C, Ekezie W, Welford A, Zhang A, et al. The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis. eClinicalMedicine. 2023;55:101762.

Routen A, O’Mahoney LL, Aiyegbusi OL, Alder Y, Banerjee A, Buckland L, et al. Patient and public involvement within epidemiological studies of long COVID in the UK. Nature Medicine. 2023;29(4):771–773.

O’Mahoney LL, Highton PJ, Kudlek L, Morgan J, Lynch R, Schofield E, et al. The impact of the COVID-19 pandemic on glycaemic control in people with diabetes: a systematic review and meta-analysis. Diabetes, Obesity and Metabolism. 2022;24(9):1850–1860.

O’Mahoney LL, Churm R, Stavropoulos-Kalinoglou A, Ajjan RA, Orsi NM, Mappa G, Price OJ, Campbell MD. Associations between erythrocyte membrane fatty acid compositions and biomarkers of vascular health in adults with type 1 diabetes. Canadian Journal of Diabetes. 2022;46(2):111–117.

O’Mahoney LL, Dunseath G, Churm R, Holmes M, Boesch C, Stavropoulos-Kalinoglou A, et al. Omega-3 polyunsaturated fatty acid supplementation versus placebo on vascular health and metabolic parameters in type 1 diabetes: a randomised controlled trial. Cardiovascular Diabetology. 2020;19(1):127.

Dr Lauren O’Mahoney supervises undergraduate and postgraduate research projects, including iMSc and PhD students, and welcomes enquiries from prospective students interested in cardiometabolic health, obesity and diabetes, multimorbidity, and the role of lifestyle interventions in the prevention and management of chronic disease.

Current Doctoral Supervision

• Sarah Hassen - Advancing the understanding of multiple long-term conditions in people living with diabetes
• Priscilla Katapa - Understanding barriers to insulin initiation in people with type 2 diabetes from ethnic minority populations

Dr Lauren O’Mahoney contributes to postgraduate teaching within the University of Leicester, including roles as a personal tutor and dissertation supervisor on the MSc Diabetes programme.

Dr Lauren O’Mahoney is available for media enquiries and commentary related to her research. Her expertise includes lifestyle and cardiometabolic health, obesity and diabetes, multimorbidity, and the role of lifestyle interventions in the prevention and management of chronic disease.