I am Professor of Biostatistics based in the Biostatistics Research Group at the University of Leicester. My research interests are in the area of Bayesian methods for evidence synthesis. The main focus of my research is in methods development and application of Bayesian multi-parameter evidence synthesis for combining data from diverse sources including multivariate meta-analysis (of multiple outcomes including surrogate endpoints) network meta-analysis and meta-analysis of data from mixture of study designs (randomised and non-randomised studies). I am particularly interested in the application of these methods in the context of HTA decision-making. I am a member of NICE Decision Support Unit and Associate Editor for the Journal of the Royal Statistical Society A.
Seo M, Debray T, Ruffieux Y, Gsteiger S, Bujkiewicz S, Finckh A, Egger M, Efthimiou O, Combining individual patient data from randomized and non-randomized studies to predict real-world effectiveness of interventions; Statistical Methods in Medical Research, 26 April 2022
Jenkins D, Hussein H, Martina R, Dequen-O'Byrne P, Abrams KR, Bujkiewicz S, Methods for the inclusion of real world evidence in network meta-analysis, BMC Medical Research Methodology 21, 207 (2021)
Dawoud D, Naci H, Ciani O and Bujkiewicz S, Raising the bar for using surrogate endpoints in drug regulation and health technology assessment, BMJ 2021;374:n2191
Singh J, Abrams KR, Bujkiewicz S, Incorporating single-arm studies in meta-analysis of randomised controlled trials: A simulation study, BMC Medical Research Methodology 21, 114 (2021).
Welton, N.J., Phillippo, D.M., Owen, R., Jones, H.J., Dias, S., Bujkiewicz, S., Ades, A.E., Abrams, K.R. DSU Report. CHTE2020 Sources and Synthesis of Evidence; Update to Evidence Synthesis Methods. March 2020
Papanikos T, Thompson JT, Abrams KR, Staedler N, Ciani O, Taylor RS, Bujkiewicz S, A Bayesian hierarchical meta-analytic method for modelling surrogate relationships that vary across treatment classes. Statistics in Medicine 2020;39:1103-1124.
Owen RK, Bujkiewicz S, Tincello DG, Abrams KR, Multivariate network meta-analysis incorporating class effects. BMC Medical Research Methodology 20, 184 (2020).
Elia EG, Staedler N, Ciani O, Taylor RS, Bujkiewicz S. Combining tumour response and progression free survival as surrogate endpoints for overall survival in advanced colorectal cancer. Cancer epidemiology. 2020 Feb 1;64:101665.
Bujkiewicz S, Achana FA, Papanikos T, Riley RD, Abrams KR, NICE DSU Technical Support Document 20: Multivariate meta-analysis of summary data for combining treatment effects on correlated outcomes and evaluating surrogate endpoints; 2019.
Bujkiewicz S, Jackson D, Thompson JR, Turner R, Staedler N, Abrams KR, White IR, Bivariate network meta-analysis for surrogate endpoint evaluation, Statistics in Medicine 2019;38:3322-3341.
Tan SH, Abrams KR, Bujkiewicz S, Bayesian multi-parameter evidence synthesis to inform decision-making: a case study in hormone-refractory metastatic prostate cancer, Medical Decision Making 2018;38(7) 834--848.
Martina R, Jenkins D, Bujkiewicz S, Dequen P, Abrams KR, The inclusion of real world evidence in clinical development planning, Trials 2018; 19, 468.
Jackson D, Bujkiewicz S, Law M, Riley RD, White I, A matrix-based method of moments for fitting multivariate network meta-analysis with multiple outcomes and random inconsistency effects, Biometrics 2018; 74, 548-556.
Burke DL, Bujkiewicz S, Riley RD, Bayesian bivariate meta-analysis of correlated effects: impact of the prior distributions on the between-study correlation, borrowing of strength, and joint inferences, Statistical Methods in Medical Research, 2018; 27 (2): 428-450.
Bujkiewicz S, Thompson JR, Riley RD, Abrams KR, Bayesian meta-analytical methods to incorporate multiple surrogate endpoints in drug development process, Statistics in Medicine, 2016; 35 (7): 1063-1089.
Bujkiewicz S, Thompson JR, Spata E, Abrams KR, Uncertainty in the Bayesian meta-analysis of normally distributed surrogate endpoints, Statistical Methods in Medical Research, 2017; 26 (5): 2287-2318.
Achana FA, Cooper NJ, Bujkiewicz S, Hubbard SJ, Kendrick D, Jones DR and Sutton AJ, Network meta-analysis of multiple outcome measures accounting for borrowing of information across outcomes, BMC Medical Research Methodology, 2014, 14:92.
Tan SH, Cooper NJ, Bujkiewicz S, Welton NJ, Caldwell DM, Sutton AJ, Novel presentational approaches were developed for reporting network meta-analysis, Journal of Clinical Epidemiology, 2014; 67(6): 672 - 680.
Bujkiewicz S, Thompson JR, Sutton AJ, Cooper NJ, Harrison MJ, Symmons DPM, Abrams KR. Multivariate meta-analysis of mixed outcomes: a Bayesian approach. Statistics in Medicine, 2013; 32: 3926 - 3943.
surrogate endpoint evaluation