I am a lecturer in Epidemiology and Genetic Epidemiology in the Department of Population Health Sciences.
My undergraduate degree was in Medicine (MBChB, 2013, Bristol), and immediately after this I joined the Wellcome Trust 4-Year PhD programme in Molecular, Genetic and Lifecourse Epidemiology (PhD, 2017, Bristol). I joined the University of Leicester in 2017 as a postdoctoral research associate, working on the discovery of common genetic variants associated with lung function. In 2019 I was awarded two fellowships by the Wellcome Trust Institutional Strategic Support Fund and the British Heart Foundation Accelerator Award, to study causal relationships between cardiorespiratory comorbidity, and its relationship with air pollution.
Since 2020, I have been involved in the development of two longitudinal cohorts (the EXCEED study, and the UK-REACH study). I am a member of the Wellcome Longitudinal Population Studies COVID-19 Steering Group, and have contributed to the design of questionnaires to understand the far-reaching impacts of the COVID-19 pandemic on health and wellbeing. I have a keen interest in the mental health and wellbeing of the healthcare workforce, and the general population.
â€¢ Pareek M, Abrams K, Abubakar I, Carr S, Dove E, Ford D, Gray L, Gupta A, Guyatt AL, John C, Khunti K, McManus C, Nellums L, Tobin M, Woolf K. UK-REACH: United Kingdom Research Study into Ethnicity And COVID-19 outcomes in Healthcare workers. (DHSC/UKRI, Â£2,100,000). 1 August 2020-2021.
â€¢ Personal Fellowships: Wellcome Trust Institutional Strategic Support Fund / British Heart Foundation Accelerator Award, joint award of Â£47,000. 2019-2020.
Woolf K, Melbourne C, Bryant L, Guyatt AL, McManus IC, Gupta A, Free RC, Nellums L, Carr S, John C, Martin CA, Wain LV, Gray LJ, Garwood C, Modhwadia V, Abrams KR, Tobin MD, Khunti K, Pareek M; UK-REACH Study Collaborative Group. The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): protocol for a prospective longitudinal cohort study of healthcare and ancillary workers in UK healthcare settings. BMJ Open. 2021 11(9):e050647. PMID: 34535484.
Magnus MC, Guyatt AL; Lawn RB, Wyss AB; Trajanoska K; Kupers LK, Rivadeneira F, Tobin MD, London SJ, Lawlor DA, Millard LAC, Fraser A. Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study. BMC Medicine. 18(1):71. PMID: 32200763.
Shrine N*, Guyatt AL*, Erzurumluoglu AM Hall IP, Tobin MD, Wain LV. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics. 2019 51(3):481-493. PMID: 30804560. *=joint first-authorship.
Guyatt AL*, Brennan RR*, Burrows K, Lawlor DA, Chinnery PF, Hudson G, Rodriguez S. A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts. Human Genomics. 2019 31;13(1):6. PMID: 30704525. *=joint first-authorship.
Guyatt AL, Rodriguez S, Gaunt TR, Fraser A, Anderson EL. Early life adiposity and telomere length across the life course: a systematic review and meta-analysis. Version 2. Wellcome Open Research. 2018 Aug 7 [revised 2018 Jan 1];2:118. PMID: 30542661.
Guyatt AL*, Burrows K*, Guthrie PAI, Ring S, McArdle W, Day INM, Ascione R, Lawlor DA, Gaunt TR, Rodriguez S. Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women. Mitochondrion. 2018 39:9-19. PMID: 28818596. *=joint first-authorship.
Mendelian randomization studies to understand causality in multimorbidity.
Epidemiological studies into mental health and wellbeing in longitudinal cohorts,
including during the COVID-19 pandemic.
I teach on the undergraduate medical degree at the University of Leicester (MBChB Population and Social Sciences module).
Press and media
â€¢ Fellow of the Higher Education Academy, 2021, University of Leicester.
â€¢ PhD, 2017, University of Bristol.
â€¢ MBChB (Distinction), 2013, University of Bristol.
â€¢ Intercalated BSc (1st Class) in Pharmacology, 2009, University of Bristol.
Since graduating with my medical degree I have exclusively worked or undertaken postgraduate training in epidemiology, i.e. please note that I am not clinically active.