Professor Martin Tobin

Professor of Genetic Epidemiology and Public Health

Chair, Leicester Precision Medicine Institute

Profile

Professor Martin Tobin is a Consultant in Public Health (Fellow of the Faculty of Public Health). He is a Fellow of the Academy of Medical Sciences, Professor of Genetic Epidemiology and Public Health at the University of Leicester, and Chair of the Leicester Precision Medicine Institute.

Since the COVID-19 pandemic, he has developed studies to improve understanding of the risk factors and consequences of COVID-19, and with local partners has designed a COVID-19 testing programme aiming to reduce viral transmission.

He leads a programme of research on the genomics of common, complex diseases to inform drug development and repositioning. His team’s research has defined the genetic variants associated with lung function and COPD. He established the first genetic study at the UK Biobank, and the resulting genetic data have led to many novel discoveries.

Professor Tobin has made national and international television appearances to increase public understanding of the risk of smoking - a key strategy in reducing smoking-related diseases.

He is Director for a PhD Programme in Genomic Epidemiology and Public Health Genomics at the University of Leicester, funded by the Wellcome Trust.

Publications

Shrine N et al. New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics 2019 Mar;51(3):481-493.

Sakornsakolpat P et al. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations. Nature Genetics 2019 Mar;51(3):494-505.

Shrine N et al. Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. The Lancet Respiratory Medicine 2019, 7(1):20-34.

Hersh CP et al. High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report. Annals of the American Thoracic Society 2019, 16(1):1-16.

Evangelou E et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics 2018, 50(10):1412-1425.

Jackson VE et al. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome open research 2018, 3:4. [joint corresponding author]

Ji X et al. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nature Communications 2018, 9(1):3221.

Miller S et al. The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis. The European respiratory journal 2018, 52(5).

Bihlmeyer NA et al. ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Circ Genom Precis Med. 2018 Jan;11(1):e001758. doi: 10.1161/CIRCGEN.117.001758. PubMed PMID: 29874175.

Adewoye AB et al. Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function. Wellcome Open  Res. 2018 Feb 21;3:13. PMID: 29682616.

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