Professor André Ng, Head of the Department of Cardiovascular Sciences, has revolutionised the way heart treatments and procedures are done.
Professor Ng is an expert in the management of cardiac arrhythmias especially in catheter ablation and the use of mapping systems in such procedures. He was appointed as Senior Lecturer in Cardiology at the University of Leicester in 2002 and Consultant Cardiologist and Electrophysiologist at the University Hospitals of Leicester and was awarded Personal Chair in Cardiac Electrophysiology in 2013.
He has played a key role in the establishment of an active ablation programme for Atrial Fibrillation since 2002 at Glenfield Hospital and has pioneered the use of a novel robotic system in AF ablation. He has provided proctorship for new ablation technologies at many centres worldwide. He also specialises in advance device implantation including pacemakers, implantable cardioverter defibrillators and cardiac resynchronisation therapy (CRT) devices.
Professor Ng has a distinguished research profile in investigations into cardiac electrophysiology and arrhythmia mechanisms, leading cross-disciplinary teams of talented researchers including basic scientists, clinical fellows and biomedical engineers.
He has translated important preclinical findings into investigations in cardiac patients with the successful development of a novel technology for sudden death risk stratification, LifeMap, which won numerous prizes including Medical Futures Award 2011 – Best Innovation in Diagnostics and European Heart Rhythm Association Inventors Award 2016, resulting in 2 internationally granted patents.
Professor Ng works closely with Industry partners in both pharmaceutical and medical device areas, conducting clinical trials as national chief investigator and principal investigator for investigator-led research grants supported by Industry funding.
Professor Ng is a Fellow of several professional societies (Royal College of Physicians and Surgeons of Glasgow, Royal College of Physicians, European Society of Cardiology, European Heart Rhythm Association and Higher Education Academy) and is Vice President (Research and Education) and Chair of the Programme Committee of the British Cardiovascular Society.
Li, X., Chu, G.S, Almeida, T.P., Vanheusden F.J., Salinet, J., Dastagir, N., Mistry, A. R., Vali, Z, Sidhu B, Starfford, P. J., Schlindwein, F.S., Ng, G.A., 2021. Automatic Extraction of Recurrent Patterns of High Dominant Frequency Mapping during Human Persistent Atrial Fibrillation. Front. Physiol (In Press), doi: 10.3389/fphys.2021.649486
Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck KH, Mont L, Ng GA, Rekosz J, Schoen N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G; EAST-AFNET 4 Trial Investigators. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med. 2020 Aug 29. doi: 10.1056/NEJMoa2019422.
Li X, Almeida TP, Dastagir N, Guillem MS, Salinet J, Chu GS, Stafford PJ, Schlindwein FS, Ng GA. Standardizing Single-Frame Phase Singularity Identification Algorithms and Parameters in Phase Mapping During Human Atrial Fibrillation. Front Physiol. 2020 Jul 21;11:869. doi: 10.3389/fphys.2020.00869.
Koeckerling D, Barker J, Mudalige NL, Oyefeso O, Pan D, Pareek M, Thompson JP, Ng GA. Awake prone positioning in COVID-19. Thorax. 2020 Jun 16:thoraxjnl-2020-215133. doi: 10.1136/thoraxjnl-2020-215133.
Zakeri R, Morgan JM, Phillips P, Kitt S, Ng GA, McComb JM, Williams S, Wright DJ, Gill JS, Seed A, Witte KK, Cowie MR; REM-HF Investigators. Prevalence and prognostic significance of device-detected subclinical atrial fibrillation in patients with heart failure and reduced ejection fraction. Int J Cardiol. 2020 Mar 3. pii: S0167-5273(19)34926-5. doi: 10.1016/j.ijcard.2020.03.008.
Chin SH, Allen E, Brack KE, Ng GA. Effects of sympatho-vagal interaction on ventricular electrophysiology and their modulation during beta-blockade. J Mol Cell Cardiol. 2020 Jan 29;139:201-212. doi: 10.1016/j.yjmcc.2020.01.011.
Zakeri R, Morgan JM, Phillips P, Kitt S, Ng GA, McComb JM, Williams S, Wright DJ, Gill JS, Seed A, Witte KK, Cowie MR; REM-HF Investigators. Impact of remote monitoring on clinical outcomes for patients with heart failure and atrial fibrillation: results from the REM-HF trial. Eur J Heart Fail. 2020 Jan 7. doi: 10.1002/ejhf.1709.
Mistry A, Vali Z, Sidhu B, Budgeon C, Yuyun MF, Pooranachandran V, Li X, Newton M, Watts J, Khunti K, Samani NJ, Ng GA. Disparity in implantable cardioverter defibrillator therapy among minority South Asians in the United Kingdom. Heart. 2020 Jan 10. pii: heartjnl-2019-315978. doi: 10.1136/heartjnl-2019-315978.
Almeida TP, Li X, Soriano DC, Schlindwein FS, Ng GA. Pitfalls in the definition of complex fractionated atrial electrograms for atrial fibrillation studies. J Cardiovasc Electrophysiol. 2019 Dec 4. doi: 10.1111/jce.14302.
Willems S, Meyer C, de Bono J, Brandes A, Eckardt L, Elvan A, van Gelder I, Goette A, Gulizia M, Haegeli L, Heidbuchel H, Haeusler KG, Kautzner J, Mont L, Ng GA, Szumowski L, Themistoclakis S, Wegscheider K, Kirchhof P. Cabins, castles, and constant hearts: rhythm control therapy in patients with atrial fibrillation. Eur Heart J. 2019 Dec 7;40(46):3793-3799c.
Mistry A, Vali Z, Taher A, Sidhu B, Li X, Newton M, Ng GA. Consideration for primary prevention implantable cardioverter defibrillators differ between specialities. Postgrad Med J. 2019 Apr;95(1122):205-209.
Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. J Physiol. 2019 Aug;597(15):3867-3883.
Hausenloy DJ, Botker HE, Ferdinandy P, Heusch G, Ng GA, Redington A, Garcia-Dorado D, on behalf of the EU-CARDIOPROTECTION COST Action (CA16225). Cardiac innervation in acute myocardial ischaemia/reperfusion injury and cardioprotection. Cardiovascular Research 2019. pii: cvz053. doi: 10.1093/cvr/cvz053.
Almeida TP, Schlindwein FS, Salinet JL, Li X, Chu GS, Tuan JH, Stafford PJ, Ng GA, Soriano DC. The temporal stability of recurrence quantification analysis attributes from chronic atrial fibrillation electrograms. Research on Biomedical Engineering 2019 (in press)
O’Shea C, Holmes AP, Yu TY, Winter J, Wells SP, Correia J, Boukens BJ, De Groot JR, Chu GS, Li X, Ng GA, Kirchhof P, Fabritz L, Rajpoot K, Pavlovic D. ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology. Nature – Scientific Reports 2019;9(1):1389. doi: 10.1038/s41598-018-38263-2.
Vanheusden FJ, Chu GS, Li X, Salinet J, Almeida TP, Dastagir N, Stafford PJ, Ng GA, Schlindwein FS. Systematic differences of non-invasive dominant frequency estimation compared to invasive dominant frequency estimation in atrial fibrillation. Comput Biol Med. 2018 pii: S0010-4825(18)30379-2. doi: 10.1016/j.compbiomed.2018.11.017.
Ng GA, Mistry A, Schlindwein FS, Nicolson WB. LifeMap: towards the development of a new technology in sudden cardiac death risk stratification for clinical use. Europace 2018;20(FI2):f162-f170. doi: 10.1093/europace/euy080.
Patel V, Karteris E, Chen J, Kyrou I, Mattu HS, Dimitriadis GK, Rodrigo G, Antoniades C, Antonopoulos A, Tan BK, Hillhouse EW, Ng A, Randeva H. Functional Cardiac Orexin Receptors: Role of Orexin-B/Orexin 2 Receptor in Myocardial Protection. Clin Sci (Lond). 2018 Nov 22. pii: CS20180150. doi: 10.1042/CS20180150.
Almeida TP, Schlindwein FS, Salinet J, Li X, Chu GS, Tuan JH, Stafford PJ, André Ng G, Soriano DC. Characterization of human persistent atrial fibrillation electrograms using recurrence quantification analysis. Chaos. 2018 Aug;28(8):085710. doi: 10.1063/1.5024248.
Trethewey SP, Nicolson WB, Ng GA. Investigation of the relationship between two novel electrocardiogram-based sudden cardiac death risk markers and autonomic function. Journal of Electrocardiology. 2018;51:889-894.