Dr Anvesha Singh

I am Consultant Cardiologist specialising in cardiac imaging (echocardiography and cardiac MRI) with an interest in clinical and translational research. I am currently based at the Department of Cardiovascular Sciences at the NIHR Leicester Biomedical Research Centre (BRC) supported by an NIHR Advanced Fellowship. Prior to my current appointment I completed my Cardiology clinical training in the East Midlands South Deanery. I took 3 years out of training to do a PhD with Professor McCann at the University of Leicester following which I was appointed as an NIHR Academic Clinical Lecturer (ACL) in Cardiology when I was awarded an Academy of Medical Sciences starter grant for clinical lecturers.

My research interests include using imaging and blood biomarkers to improve risk stratification in aortic stenosis the commonest valve lesion requiring surgery in the western world. My PhD looked at the role of a novel imaging biomarker (myocardial perfusion reserve) in predicting symptom onset and adverse outcomes in initially asymptomatic aortic stenosis the results of which were published in the European Heart Journal the highest ranking Cardiology journal and for which I won two young investigator awards (BHVS 2015 and SCMR 2016). I am using novel imaging techniques and contrast agents to better understand the pathophysiology of symptom development and adverse cardiac remodeling in aortic stenosis. I am also collaborating with colleagues to understand the role of biomarkers including microRNAs and the development of myocardial fibrosis. During my Fellowship I plan to conduct a qualitative sub-study in collaboration with qualitative researchers at the University of Sheffield.

Kwak S, Everett RJ, Treibel TA, Yang S, Hwang D, Ko T, Williams MC, Bing R, Singh T, Joshi S, Lee H, Lee W, Kim YJ, Chin CWL, Fukui M, Al Musa T, Rigolli M, Singh A, Tastet L, Dobson LE, Wiesemann S, Ferreira VM, Captur G, Lee S, Schulz-Menger J, Schelbert EB, Clavel MA, Park SJ, Rheude T, Hadamitzky M, Gerber BL, Newby DE, Myerson SG, Pibarot P, Cavalcante JL, McCann GP, Greenwood JP, Moon JC, Dweck MR, Lee SP. Markers of Myocardial Damage Predict Mortality in Patients With Aortic Stenosis. J Am Coll Cardiol. 2021 Aug 10;78(6):545-558. 

Chan DCS*, Singh A*, Greenwood JP et al. Effect of the 2017 European Guidelines on Reclassification of Severe Aortic Stenosis and Its Influence on Management Decisions for Initially Asymptomatic Aortic Stenosis. Circ Cardiovasc Imaging. 2020 Dec;13(12):e011763. PMID: 33287584 (*joint 1st authors)

Singh A, Chan DCS, Kanagala P et al. Short-term adverse remodeling progression in asymptomatic aortic stenosis. Eur Radiol. 2020 Nov 19. PMID: 33215248

Alfuhied A, Marrow BA, Elfawal S, Gulsin GS, Graham-Brown MP, Steadman CD, Kanagala P, McCann GP, Singh A. Reproducibility of left atrial function using cardiac magnetic resonance imaging. Eur Radiol. 2020 Oct 30. PMID: 33128187

Singh A, Loke I, Khoo JP. A Man in His 80s With Dyspnea and a Malpositioned Pacemaker Lead. JAMA Cardiol. 2020 Jun 1;5(6):725. PMID: 32347886

Everett RJ, Treibel TA, Fukui M, Lee H, Rigolli M, Singh A et al. Extracellular Myocardial Volume in Patients With Aortic Stenosis. J Am Coll Cardiol. 2020 Jan 28;75(3):304-316. PMID: 31976869

Singh A, Jerosch-Herold M, Bekele S et al. Determinants of Exercise Capacity and Myocardial Perfusion Reserve in Asymptomatic Patients With Aortic Stenosis. JACC Cardiovasc Imaging. 2019 Sep 12. PMID: 31542537

Singh A, Musa TA, Treibel TA et al. Sex differences in left ventricular remodeling, myocardial fibrosis and mortality after aortic valve replacement. Heart. 2019 Aug. PMID: 31467152

Graham-Brown MP, Gulsin GS, Parke K, Wormleighton J, Lai FY, Athithan L, Arnold JR, Burton JO, McCann GP, Singh A. A comparison of the reproducibility of two cine-derived strain software programmes in disease states. Eur J Radiol. 2019 Apr;113:51-58. PMID:30927959

Singh A, Horsfield MA, Bekele S et al. Aortic stiffness in aortic stenosis assessed by cardiovascular MRI: a comparison between bicuspid and tricuspid valves. Eur Radiol. 2018 Nov 28. PMID: 30488106

Singh A, McCann GP. Cardiac magnetic resonance imaging for the assessment of aortic stenosis. Heart. 2018 Oct 15. PMID: 30322845.

Musa TA, Treibel TA, Vassiliou VS, Captur G, Singh A et al. Myocardial Scar and Mortality in Severe Aortic Stenosis: Data from the BSCMR Valve Consortium. Circulation. 2018 Oct 30;138(18):1935-1947. PMID: 30002099

Singh A, Chan DCS, Greenwood JP et al. Symptom Onset in Aortic Stenosis: Relation to Sex Differences in Left Ventricular Remodeling. JACC Cardiovasc Imaging. 2017 Dec 8. PMID: 29248646.

Singh A, Greenwood JP, Berry C et al. Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) Study. Eur Heart J. 2017 April 21;38(16):1222-1229. PMID: 28204448.

MRI in aortic stenosis and other cardiac diseases Novel MRI sequences and contrast agents Biomarkers in aortic stenosis

I became a fellow of the Higher Education Academy (FHEA) in February 2021. I regularly participate as faculty/presenter at national/international Cardiology/ cardiac MRI conferences. I regularly train research Fellows/ Cardiology SpRs in clinical cardiac MRI and contribute to assessment of medical students and undergraduates at the university. I am the primary supervisor for 2 PhD students and regularly supervise iMSc medical students.

Aortic Stenosis

-Member of the British Society of cardiac MRI (BSCMR) trainee committee until 2019. Now the regional BSCMR training lead for East Midlands and a member of the BSCMR valve working group. -Locally I am the clinical co-lead for the Translational Medical Fac

-Fellow of the Higher Education Academy (2021) -EACVI Level-3 CMR accreditation (2019) -SCCT Level-2 cardiac CT accreditation (2019) -CCT in Cardiology (2019) -British Society of Echocardiography TOE/TTE accreditation (2017/2018) -PhD (Role of cardiac mag