People

Dr Lucy Beishon

NIHR Academic Clinical Lecturer

Telephone: +44 (0)116 252 3134

Email: lb330@leicester.ac.uk

Address: Room 439 Robert Kilpatrick Clinical Sciences Building Leicester Royal Infirmary University of Leicester LE2 7LX

Profile

I am currently working at the University of Leicester as an NIHR Academic Clinical Lecturer in Geriatric medicine with an interest in cognitive disorders. I am particularly interested in how brain blood flow is altered or damaged in dementia and how this contributes to the development or progression of different types of dementia. I was previously funded by the Dunhill Medical Trust on my research training fellowship project entitled ‘The Cognition & Flow Study: The effects of brain training on brain blood flow.’ This study investigated the use of cognitive or “brain training “as a treatment for Alzheimer’s disease and mild cognitive impairment and as prevention in healthy older adults. In addition to my research work I am also a specialist trainee in Geriatric Medicine and my long-term goal is to work as a Geriatrician with clinical and research interests in dementia. My current research focusses on improving physical care for older people on in-patient mental health units, and vascular mechanisms linking common disorders of ageing (dementia, delirium, and depression).

Research

  • Improving physical health care in older people living with dementia in mental health settings: The ImPreSs-Care Study - 2022 - ongoing

  • Vascular mEchanismS in, dePression, dementiA, and deliRum: The VESPAR project - 2022 - ongoing

  • Improving the detection of cardioembolic stroke using stroke simulation and machine learning techniques - 2021- ongoing

  • INFOMATAS multi-centre individual patient data meta-analysis of cerebral autoregulation in acute ischaemic stroke - 2018- ongoing

  • Frailty and cognitive assessment in the TIA service 2021 - ongoing

  • Ethnicity, outcomes, and cognitive assessment in dementia - 2021 - ongoing

  • The effects of ageing on neurovascular coupling under different physiological conditions - 2021-2022

  • The Effects of Brain Training on Brain Blood Flow: The Cognition and Flow Study - 2018-2021

  • Cerebral haemodynamic assessment in mild cognitive impairment and dementia - 2017-2018

Publications

(0)

  • Diagnostic test accuracy of remote, multidomain cognitive assessment (telephone and video call) for dementia. Beishon LC, Elliott E, Hietamies TM, Mc Ardle R, O'Mahony A, Elliott AR, Quinn TJ. Cochrane Database Syst Rev. 2022.
  • Effect of Antihypertensive Treatment on Cerebral Blood Flow in Older Adults: a Systematic Review and Meta-Analysis. van Rijssel AE, Stins BC, Beishon LC, Sanders ML, Quinn TJ, Claassen JAHR, de Heus RAA. Hypertension. 2022.
  • International Research Priority Setting Exercises in Stroke - Systematic Review. Leitch SL, Logan M, Beishon L, Quinn TJ. Int J Stroke. 2022.
  • The Cognition and Flow Study (CogFlowS): A Mixed Method Evaluation of a Randomized Feasibility Trial of Cognitive Training in Dementia.
    Beishon L, Haunton V, Bradbury-Jones C, Subramaniam H, Mukaetova-Ladinska EB, Panerai RB, Robinson T, Evley R. J Alzheimers Dis. 2022
  • Oral antiplatelet therapy for acute ischaemic stroke. Minhas JS, Chithiramohan T, Wang X, Barnes SC, Clough RH, Kadicheeni M, Beishon LC, Robinson T. Cochrane Database Syst Rev. 2022.
  • Paediatric brain MRI findings following congenital heart surgery: a systematic review. Alablani FJ, Chan HSA, Beishon L, Patel N, Almudayni A, Bu'Lock F, Chung EM. Arch Dis Child. 2022.
  • Cerebrovascular responses to somatomotor stimulation in Parkinson's disease: A multivariate analysis. Barnes SC, Panerai RB, Beishon L, Hanby M, Robinson TG, Haunton VJ. J Cereb Blood Flow Metab. 2022
  • Investigating the association between depression and cerebral haemodynamics-A systematic review and meta-analysis. Chithiramohan T, Parekh JN, Kronenberg G, Haunton VJ, Minhas JS, Panerai RB, Robinson TG, Divall P, Subramaniam H, Mukaetova-Ladinska E, Beishon L. J Affect Disord. 2022.
  • The Interaction of Dynamic Cerebral Autoregulation and Neurovascular Coupling in Cognitive Impairment. Beishon LC, Intharakham K, Haunton VJ, Robinson TG, Panerai RB. Curr Alzheimer Res. 2021.
  • Extremes of cerebral blood flow during hypercapnic squat-stand maneuvers. Barnes SC, Haunton VJ, Beishon L, Llwyd O, Robinson TG, Panerai RB. Physiol Rep. 2021
  • Cerebral Autoregulation and Neurovascular Coupling in Acute and Chronic Stroke. Beishon LC, Minhas JS. Front Neurol. 2021.
  • The Neurovascular Unit in Dementia: An Opinion on Current Research and Future Directions. Beishon L, Panerai RB. Front Aging Neurosci. 2021.
  • The Interaction of Dynamic Cerebral Autoregulation and Neurovascular Coupling in Cognitive Impairment. Beishon LC, Intharakham K, Haunton VJ, Robinson TG, Panerai RB. Curr Alzheimer Res. 2021.
  • Cerebral blood flow response rate to task-activation using a novel method can discriminate cognitive impairment from healthy aging. Beishon L, Panerai RB, Robinson TG, Haunton VJ. Physiol Meas. 2021
  • Vascular and haemodynamic issues of brain ageing. Beishon L, Clough RH, Kadicheeni M, Chithiramohan T, Panerai RB, Haunton VJ, Minhas JS, Robinson TG. Pflugers Arch. 2021.
  • Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial. Beishon L, Woodhouse LJ, Bereczki D, Christensen HK, Collins R, Gommans J, Kruuse C, Ntaios G, Ozturk S, Phillips S, Pocock S, Szatmari S, Wardlaw J, Sprigg N, Bath PM; for ENOS Investigators. Stroke Vasc Neurol. 2021.
  • Cerebral Autoregulation in Ischemic Stroke: From Pathophysiology to Clinical Concepts. Nogueira RC, Beishon L, Bor-Seng-Shu E, Panerai RB, Robinson TG. Brain Sci. 2021.
  • The Cognition and Flow Study: A Feasibility Randomized Controlled Trial of the Effects of Cognitive Training on Cerebral Blood Flow. Beishon LC, Panerai RB, Budgeon C, Subramaniam H, Mukaetova-Ladinska E, Robinson TG, Haunton VJ. J Alzheimers Dis. 2021.
  • Qualitative Analysis of the Cognition and Flow (CoGFlowS) Study: An Individualized Approach to Cognitive Training for Dementia Is Needed. Beishon L, Haunton V, Subramaniam H, Mukaetova-Ladinska EB, Panerai RB, Robinson T, Evley R. J Alzheimers Dis. 202.
  • Age-related differences in cerebrovascular responses to cognitive stimulation using a novel method. Beishon LC, Boadi E, Williams CA, Chithiramohan T, Barnes SC, Intharakham K, Batterham AP, Haunton VJ, Robinson TG, Panerai RB.Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021.
  • Neuroimaging Outcomes in Studies of Cognitive Training in Mild Cognitive Impairment and Early Alzheimer's Disease: A Systematic Review. Beishon L, Intharakham K, Swienton D, Panerai RB, Robinson TG, Haunton VJ. Curr Alzheimer Res. 2020.
  • INFOMATAS multi-center systematic review and meta-analysis individual patient data of dynamic cerebral autoregulation in ischemic stroke. Beishon L, Minhas JS, Nogueira R, Castro P, Budgeon C, Aries M, Payne S, Robinson TG, Panerai RB. Int J Stroke. 2020.
  • Addenbrooke's Cognitive Examination III (ACE-III) and mini-ACE for the detection of dementia and mild cognitive impairment. Beishon LC, Batterham AP, Quinn TJ, Nelson CP, Panerai RB, Robinson T, Haunton VJ. Cochrane Database Syst Rev. 2019.
  • Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting. Kokkinou M, Beishon LC, Smailagic N, Noel-Storr AH, Hyde C, Ukoumunne O, Worrall RE, Hayen A, Desai M, Ashok AH, Paul EJ, Georgopoulou A, Casoli T, Quinn TJ, Ritchie CW. Cochrane Database Syst Rev. 2021.
  • Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study. Geriatric Medicine Research Collaborative; Covid Collaborative, Welch C. Age Ageing. 2021
  • An objective method to identify non-responders in neurovascular coupling testing. Beishon LC, Williams CA, Intharakham K, Batterham AP, Barnes SC, Haunton VJ, Robinson TG, Panerai RB.J Neurosci Methods. 2021.
  • Addenbrooke's Cognitive Examination III (ACE-III) and mini-ACE for the detection of dementia and
    mild cognitive impairment. Beishon LC, Batterham AP, Quinn TJ, Nelson CP, Panerai RB,
    Robinson T, Haunton VJ. Cochrane Database Syst Rev. 2019.
  • Assessment of cerebral autoregulation in stroke: A systematic review and meta-analysis of studies at rest. Intharakham K, Beishon L, Panerai RB, Haunton VJ, Robinson TG. J Cereb Blood Flow Metab. 2019.
  • The Effects of Healthy Ageing on Cerebral Blood Flow Responses to Cognitive Testing. Beishon L, Minhas JS, Patrick K, Shanmugam I, Williams CAL, Panerai RB, Robinson TG, Haunton VJ. Curr Aging Sci. 2019.
  • The Assessment of Cerebrovascular Response to a Language Task from the Addenbrooke's Cognitive Examination in Cognitive Impairment: A Feasibility Functional Transcranial Doppler Ultrasonography Study. Beishon LC, Panerai RB, Robinson TG, Subramaniam H, Haunton VJ. J Alzheimers Dis Rep. 2018.
  • Effects of brain training on brain blood flow (The Cognition and Flow Study-CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia. Beishon L, Evley R, Panerai RB, Subramaniam H, Mukaetova-Ladinska E, Robinson T, Haunton V. BMJ Open. 2019.
  • Multi-disciplinary Geriatric Oncology Clinics (book chapter). In book: Management of Breast Cancer in Older Women. Ugolini F, Beishon L, Malcolm W, Stotter A, Wright J, Robinson TG. 2019.
  • Neurovascular coupling response to cognitive examination in healthy controls: a multivariate analysis. Beishon L, Williams CAL, Robinson TG, Haunton VJ, Panerai RB. Physiol Rep. 2018.
  • The assessment of neurovascular coupling with the Addenbrooke's Cognitive Examination: a functional transcranial Doppler ultrasonographic study. Beishon LC, Williams CAL, Panerai RB, Robinson TG, Haunton VJ. J Neurophysiol. 2018
  • Relationship between race and outcome in Asian, Black, and Caucasian patients with spontaneous intracerebral hemorrhage: Data from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke trial. Krishnan K, Beishon L, Berge E, Christensen H, Dineen RA, Ozturk S,
    Sprigg N, Wardlaw JM, Bath PM; VISTA-ICH collaboration and ENOS Investigators. Int J Stroke. 2018.
  • Cerebral Hemodynamics in Mild Cognitive Impairment: A Systematic Review. Beishon L, Haunton VJ, Panerai RB, Robinson TG. J Alzheimers Dis. 2017.
  • Reproducibility of task activation using the Addenbrooke's cognitive examination in healthy
    controls: A functional Transcranial Doppler ultrasonography study. Beishon L, Williams CAL, Panerai RB, Robinson TG, Haunton VJ. J Neurosci Methods. 2017.
  • The evidence for treating hypertension in older people with dementia: a systematic review. Beishon LC, Harrison JK, Harwood RH, Robinson TG, Gladman JR, Conroy SP. J Hum Hypertens. 2014.
  • Long-term activation of polymorph cannabinoid receptors does not affect receptor gene transcription. Beishon L, McDonald J, Thompson JP, Lambert DG. Br J Anaesth. 2014.
  • Cannabinoids and sepsis. Ladak N, Beishon L, Thompson JP, Lambert D. Trends in Anaesthesia and Critical Care 2011.
.

Supervision

  • Dementia and cognitive disorders

  • Neurovascular coupling

  • Transcranial Doppler ultrasonography

  • Cognitive interventions

  • Stroke

Teaching

  • Biological sciences (undergraduate)

  • Intercalated Masters degree

  • Cardiovascular MRes

  • PhD

Activities

  • Membership to the Royal College of Physicians and British Geriatrics Society

  • Associate Editor for the Journal of Alzheimer's Disease

  • Member of the Cerebral Autoregulation Network

Awards

  • The Ballantine Prize (2009)

  • The prize for the Best Dissertation of the Year (2010, local)

  • Day Winner Prize for a conference presentation (European Student’s Conference 2011)

  • First Prize for a poster presentation at the Healthy Ageing Summer School (2012)

  • The Very Reverend Derek Hole Prize in Cardiovascular Medicine. University of Leicester (2013)

Conferences

  • Cerebral Autoregulation Network 2021: Response rate to task-activation can discriminate Alzheimer's disease and mild cognitive impairment from healthy aging: clinical application of a novel method. Lucy Beishon Ronney B Panerai Thompson G Robinson Victoria J Haunton.

  • Cerebral Autoregulation Network 2021: The Effects of Brain Training on Brain Blood Flow: Results from the Cognition and Flow Study (CoGFlowS). L. Beishon R.B. Panerai H. Subramaniam E. Mukaetova-Ladinska T.G. Robinson V.J. Haunton.

  • Alzheimer's Research UK 2021: The mechanisms of neuroplasticity induced by cognitive training in dementia: a systematic review. Lucy Beishon Kannakorn Intharakham Ronney B Panerai Thompson G Robinson Victoria J Haunton.

  • British Geriatrics Society Spring Meeting 2021: Qualitative assessment of cognitive training for people living with dementia: An individualised approach is needed. Lucy Beishon Victoria Haunton Hari Subramaniam Elizabeta Mukaetova-Ladinska Ronney Panerai Thompson Robinson Rachel Evley.

Qualifications

BSc MBChB MRes PhD MRCP AFHEA

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