People
Dr Will Nicolson
Consultant Cardiologist / Honorary Senior Lecturer in Cardiology
School/Department: Cardiovascular Sciences, Department of
Email: wbn1@leicester.ac.uk
Profile
Research
Sudden cardiac death remains a major clinical problem causing 3 million deaths per year worldwide and yet it is very preventable with an implantable cardioverter defibrillator. The limitation is in our inability to accurately assess the risk of sudden cardiac death. LifeMap uses novel electrical restitution based ECG markers to accurately assess risk of life threatening arrhythmias. In collaboration with Prof. Andre Ng and Dr Fernando Schlindwein my research has won numerous awards attracted £1.6million in funding and has been protected by two patents. LifeMap is an example of successful bench to bedside translation of departmental basic science research. Complex digital signal processing using MATLAB in collaboration with Engineering and Industry (Mortara Instrument Inc) is a cornerstone of the successful development of LifeMap. I am also working on improving signal acquisition with design company Renfrew Group International.
I have also acted as principle investigator for a number of mulpt
For further information on LifeMap please see: https://life-map.co.uk/
Publications
William, B., Nicolson Matthew I., Smith Zakariyya, Vali Nilesh, J., Samani, G., André, Ng. Application of two novel electrical restitution-based ECG markers of ventricular arrhythmia to patients with nonischemic cardiomyopathy Pacing Clin Electrophysiol. 2020;1-9.
Abdalwahid, K.F., Chu G.S., Nicolson, W.B. A case report: upgrade to cardiac resynchronization therapy with a blocked persistent left-sided superior vena cava. Eur Heart J Case Rep. 2020 Feb 21;4(2):1-5. doi: 10.1093/ehjcr/ytaa015.
Trethewey, S.P., Nicolson, W.B., Ng, G.A. Investigation of the relationship between two novel electrocardiogram-based sudden cardiac death risk markers and autonomic function. Journal of Electrocardiology 2018; 51 889 - 894
Bhandari, S.S., Nicolson, W.B. Recurrent valve obstruction in a patient with a pure carbon bileaflet metallic mitral valve: a case report European Heart Journal - Case Reports Volume 2 Issue 3 1 September 2018 Pages 1-7 https://doi.org/10.1093/ehjcr/yty089
Ng, G.A., Mistry, A., Li X., Schlindwein, F.S., Nicolson, W.B., LifeMap: towards the development of a new technology in sudden cardiac death risk stratification for clinical use EP Europace 2018: https://doi.org/10.1093/europace/euy080
Yuyun M.F., Loke, I., Nicolson, W.B., Clayton, L., Squire, I.B. (2016) Secondary Care Rapid Access Heart Failure Clinics for Reduction in Hospitalisa¬tion. J Cardiol Clin Res 4(3): 1062
Nicolson, W.B., McCann, G.P., Smith, M.I., Sandilands, A.J., Stafford, P.J., Schlindwein, F.S., Samani, N.J., Ng, G.A. Prospective evaluation of two novel electrocardiogram based restitution biomarkers for prediction of sudden cardiac death risk in ischaemic cardiomyopathy. 2014;100(23):1878-85
Madeiro, J.P. V., Nicolson, W,B., Cortez, P.C., Marques, J. a L. Vázquez-Seisdedos, C.R., Elangovan N. et al. New approach for T-wave peak detection and T-wave end location in 12-lead paced ECG signals based on a mathematical model. Medical Engineering and Physics. Institute of Physics and Engineering in Medicine; 2013;35:1105-15.
Nicolson, W.B., McCann, G.P., Brown, P., Sandilands, A.J., Stafford, P.J., Schlindwein, F.S., Samani, N.J., Ng G.A. A Novel Surface Electrocardiogram Based Marker of Ventricular Arrhythmia Risk in Patients with Ischemic Cardiomyopathy. J Am Heart Assoc. 2012;1:e001552
Supervision
Teaching
I deliver weekly educational sessions to junior doctors using MS Teams. I also lecture medical students and on the MRes Physiology and pharmacology module.
Please see my YouTube channel if you are interested to see more:
https://www.youtube.com/channel/UCwYM3gcEahuePKGuVa9bp_g
Press and media
Activities
Patents:
- 22 March 2010 'Method and Apparatus for Evaluating Cardiac Function' (WO2011117608) granted in China Japan USA and Australia; under review in Canada Europe and India.
- 4 April 2014 'ECG Evaluation' (WO2015150831) granted in USA Japan Australia; under review in Canada Europe and China.
Awards
2016 European Heart Rhythm Association Inventor's Award,
2014 College of Medicine, Biological Sciences & Psychology PhD award, University of Leicester
2014 ISCOMS Best Oral Presentation Award (Primary Supervisor to BSc medical student)
2012 Royal Society Medicine - Cardiology Medal President's Medal (finalist)
2011 Design Council - Innovate for Universities
2011 Young Investigator Award - Clinical, Heart Rhythm Congress
2011 Medical Futures Award - Best Innovation in Cardiovascular Diagnostics
2011 EMESP Masters Prize - Overall Winner
2011 Young Research Worker Prize, CardioRhythm
2010 Clinical Impact Da Vinci Award: £15,000