People
Professor David Adlam
School/Department: Cardiovascular Sciences, Department of
Email: da134@leicester.ac.uk
Profile
I am an interventional cardiologist with practice in coronary stenting. Working within the Leicester NIHR Biomedical Research Centre my research interests include:
- Rare cardiovascular diseases including spontaneous coronary artery dissection (SCAD) coronary aneurysms and ectasia (CAE) and fibromuscular dysplasia (FMD)
- Novel medical devices
- Cardio-oncology
- Big data linkage to better understand disease interactions and comorbidity
- Diagnosis and management of coronary artery diseases and acute myocardial infarction
Research
Selected research studies
Spontaneous Coronary Artery Dissection (SCAD): I lead the UK SCAD study currently supported by the patient charity BeatSCAD. I also chair the ESC-ACVC SCAD Study Group and the ESC-EORP SCAD registry.
The Virtual Cardio-oncology research initiative (VICORI); I am the joint lead investigator for this national data linkage initiative to connect cardiovascular and cancer data in order to better understand the interrelationship between the two commonest caused of morbidity and mortality in the UK.
Current Patents
PAL cardiac balloon support device: EP3277337A1
Angioplasty of calcified arteries: PCT/GB2017/050877
Failsafe shunt device: UK Patent application number 2211616.4
Awards and Nominations
2021 - LAUDIX award (Papworth Hospital, Cambridge, UK)
2018 - Paul Dudley White International Scholar Award
2017 - BHF Heart Hero Award
2017 - Exceptional PPIE Engagement CRN E Mids Award
2003 - Wellcome Trust Junior Research Fellowship
1992-1998 - Scholarship of Christ Church Oxford
Publications
Selected recent publications
Adlam D, Berrandou TE, Georges A, Nelson CP, Giannoulatou E, Henry J, Ma L, Blencowe M, Turley TN, Yang ML, Chopade S, Finan C, Braund PS, Sadeg-Sayoud I, Iismaa SE, Kosel ML, Zhou X, Hamby SE, Cheng J, Liu L, Tarr I, Muller DWM, d'Escamard V, King A, Brunham LR, Baranowska-Clarke AA, Debette S, Amouyel P, Olin JW, Patil S, Hesselson SE, Junday K, Kanoni S, Aragam KG, Butterworth AS; CARDIoGRAMPlusC4D; MEGASTROKE; International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group; Tweet MS, Gulati R, Combaret N; DISCO register; Kadian-Dodov D, Kalman JM, Fatkin D, Hingorani AD, Saw J, Webb TR, Hayes SN, Yang X, Ganesh SK, Olson TM, Kovacic JC, Graham RM, Samani NJ, Bouatia-Naji N. Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation. Nat Genet. 2023 Jun;55(6):964-972. doi: 10.1038/s41588-023-01410-1. Epub 2023 May 29.PMID: 37248441
Teece L, Sweeting MJ, Hall M, Coles B, Oliver-Williams C, Welch CA, de Belder MA, Deanfield J, Weston C, Rutherford MJ, Paley L, Kadam UT, Lambert PC, Peake MD, Gale CP, Adlam D; VICORI Collaborative. Impact of a Prior Cancer Diagnosis on Quality of Care and Survival Following Acute Myocardial Infarction: Retrospective Population-Based Cohort Study in England.Circ Cardiovasc Qual Outcomes. 2023 Jun;16(6):e009236. doi: 10.1161/CIRCOUTCOMES.122.009236. Epub 2023 Jun 20. PMID: 37339190
Zeymer U, Freund A, Hochadel M, Ostadal P, Belohlavek J, Rokyta R, Massberg S, Brunner S, Lüsebrink E, Flather M, Adlam D, Bogaerts K, Banning A, Sabaté M, Akin I, Jobs A, Schneider S, Desch S, Thiele H. Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials. Lancet. 2023 Aug 25:S0140-6736(23)01607-0. doi: 10.1016/S0140-6736(23)01607-0. Online ahead of print. PMID: 37643628
Chan N, Premawardhana D, Al-Hussaini A, Wood A, Bountziouka V, Kotecha D, Swahn E, Palmefors H, Pagonis C, Sederholm Lawesson S, Kądziela J, Garcia-Guimarães M, Alfonso F, Escaned J, Macaya F, Santás M, Cerrato E, Maas AHEM, Hlinomaz O, Bogale N, Cortese B, Cheng M, Bolger A, Hussain ST, Samani NJ, Knight M, Cauldwell M, Adlam D. Pregnancy and Spontaneous Coronary Artery Dissection: Lessons From Survivors and Nonsurvivors. Circulation. 2022 Jul 5;146(1):69-72. doi: 10.1161/CIRCULATIONAHA.122.059635. Epub 2022 Jun 3. PMID: 35656808
Persu A, Lopez-Sublet M, Al-Hussaini A, Pappaccogli M, Radhouani I, Van der Niepen P, Adair W, Beauloye C, Brillet PY, Chan N, Chenu P, Devos H, Escaned J, Garcia-Guimaraes M, Hammer F, Jackson R, Jebri S, Kotecha D, Macaya F, Mahon C, Natarajan N, Neghal K, Nicol ED, Parke KS, Premawardhana D, Sajitha A, Wormleighton J, Samani NJ, McCann GP, Adlam D. Prevalence and Disease Spectrum of Extracoronary Arterial Abnormalities in Spontaneous Coronary Artery Dissection. JAMA Cardiol. 2022 Feb 1;7(2):159-166. doi: 10.1001/jamacardio.2021.4690.PMID: 34817541
Margaritis M, Saini F, Baranowska-Clarke AA, Parsons S, Vink A, Budgeon C, Alcock N, Wagner BE, Samani NJ, von der Thüsen J, Robertus JL, Sheppard MN, Adlam D. Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. Cardiovasc Res. 2022 Jun 22;118(7):1835-1848. doi: 10.1093/cvr/cvab183. PMID: 34048532
Carss KJ, Baranowska AA, Armisen J, Webb TR, Hamby SE, Premawardhana D, Al-Hussaini A, Wood A, Wang Q, Deevi SVV, Vitsios D, Lewis SH, Kotecha D, Bouatia-Naji N, Hesselson S, Iismaa SE, Tarr I, McGrath-Cadell L, Muller DW, Dunwoodie SL, Fatkin D, Graham RM, Giannoulatou E, Samani NJ, Petrovski S, Haefliger C, Adlam D. Spontaneous Coronary Artery Dissection: Insights on rare genetic variation from genome sequencing. Circ Genom Precis Med. 2020 Dec;13(6):e003030. doi: 10.1161/CIRCGEN.120.003030. Epub 2020 Oct 30. PMID: 33125268
Al-Hussaini A, Abdelaty AMSEK, Gulsin GS, Arnold JR, Garcia-Guimaraes M, Premawardhana D, Budgeon C, Wood A, Natarajan N, Mangion K, Rakhit R, Hoole SP, Johnson TW, Berry C, Hudson I, Gershlick AH, Ladwiniec A, Kovac J, Squire I, Samani NJ, Plein S, McCann GP, Adlam D. Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management. Eur Heart J. 2020 Jun 14;41(23):2197-2205. doi: 10.1093/eurheartj/ehz895.Eur Heart J. 2020.PMID: 31898721
Verstraeten A, Perik MHAM, Baranowska AA, Meester JAN, Van Den Heuvel L, Bastianen J, Kempers M, Krapels IPC, Maas A, Rideout A, Vandersteen A, Sobey G, Johnson D, Fransen E, Ghali N, Webb T, Al-Hussaini A, de Leeuw P, Delmotte P, Lopez-Sublet M, Pappaccogli M, Sprynger M, Toubiana L; European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI); Van Laer L, Van Dijk FS, Vikkula M, Samani NJ, Persu A, Adlam D, Loeys B; Collaborators of the European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI). Enrichment of Rare Variants in Loeys-Dietz Syndrome Genes in Spontaneous Coronary Artery Dissection but Not in Severe Fibromuscular Dysplasia. Circulation. 2020 Sep 8;142(10):1021-1024. doi: 10.1161/CIRCULATIONAHA.120.045946. Epub 2020 Sep 8. PMID: 32897753
Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O'Byrne MM, Bouajila S, Georges A, Mishra K, Braund PS, d'Escamard V, Huang S, Margaritis M, Nelson CP, de Andrade M, Kadian-Dodov D, Welch CA, Mazurkiewicz S, Jeunemaitre X; DISCO Consortium, Wong CMY, Giannoulatou E, Sweeting M, Muller D, Wood A, McGrath-Cadell L, Fatkin D, Dunwoodie SL, Harvey R, Holloway C, Empana JP, Jouven X; CARDIoGRAMPlusC4D Study Group, Olin JW, Gulati R, Tweet MS, Hayes SN, Samani NJ, Graham RM, Motreff P, Bouatia-Naji N. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019 Jan 8;73(1):58-66. doi: 10.1016/j.jacc.2018.09.085.q
Jackson R, Al-Hussaini A, Joseph S, van Soest G, Wood A, Macaya F, Gonzalo N, Cade J, Caixeta A, Hlinomaz O, Leinveber P, O'Kane P, García-Guimaraes M, Cortese B, Samani NJ, Escaned J, Alfonso F, Johnson T, Adlam D. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography. JACC Cardiovasc Imaging. 2019 Dec;12(12):2475-2488. doi: 10.1016/j.jcmg.2019.01.015. Epub 2019 Mar 13. PMID: 30878439
Adlam D, Alfonso F, Maas A, Vrints C; Writing Committee. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J. 2018 Feb 22. doi: 10.1093/eurheartj/ehy080.
Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. Circulation. 2018 May 8;137(19):e523-e557. doi: 10.1161/CIR.0000000000000564. Epub 2018 Feb 22.
Supervision
Candidates interested in working towards either MD or PhD either preclinically or clinically should contact me directly on da134@le.ac.uk.
Teaching
I support medical education of both preclinical, clinical and post graduate students
Interests
Book chapter
Adlam D Alfonso F Mass A Persu A Vrints C. Spontaneous Coronary Artery Dissection. Chapter in; The PCR - EAPCI Textbook. Percutaneous Interventional Cardiovascular Medicine. Eds. De Palma R Capranzano P
Adlam D. The ECG in Practice 5th and 6th and 7th Editions. Ed. Hampton JR. Elsevier Ltd. 2008 2015 2019(winner of the BMJ book award (cardiology) 2009 and 150 ECG Cases 5th Edition 2019
Adlam D Prendergast BD. Angiography: Indications and limitations. Chapter in: Oxford textbook of interventional cardiology. Eds. Redwood S Curzon N Redwood M. Oxford University Press 2010 and 2nd Edition 2018
Adlam D Adnan A. Coronary artery disease and acute coronary syndrome. Chapter in ABC of arterial and venous diseases Wiley 2014
Adlam D Forfar C. Pericardial disease. Chapter in: Cardiology Medicine International Eds. Prendergast BD 2010 2015 and 2018
Adlam D. Coronary imaging. Chapter in: Cardiovascular Imaging. Ed Leeson P. Oxford University press 2011
Adlam D. Pericardial disease. Chapter in: Oxford Diagnosis and Treatment in Internal Medicine. Eds. Davey P Sprigings D. Oxford University press 2010
Media coverage
- https://www.bhf.org.uk/informationsupport/heart-matters-magazine/research/future-of-lvads
- https://www.theengineer.co.uk/heart-pump-lvad-leicester/
- http://www.bbc.co.uk/news/uk-39106357
- http://www.itv.com/news/2016-02-29/new-trial-into-potentially-deadly-condition-that-affects-otherwise-healthy-women/