Dr David Adlam

I am an interventional cardiologist with practice in coronary stenting and TAVI valve implantation. Working within the Leicester NIHR Biomedical Research Centre my research interests include:

• Rare cardiovascular diseases including spontaneous coronary artery dissection (SCAD) coronary aneurysms and ectasia (CAE) and fibromuscular dysplasia (FMD)

• Novel medical devices

• Cardio-oncology

• Big data linkage to better understand disease interactions and comorbidity

• Diagnosis and management of coronary artery diseases and acute myocardial infarction 

Selected research studies

Spontaneous Coronary Artery Dissection (SCAD): I lead the UK SCAD study currently supported by the patient charity BeatSCAD. I also chair the ESC-ACVC SCAD Study Group and the ESC-EORP SCAD registry.

The Virtual Cardio-oncology research initiative (VICORI); I am the joint lead investigator for this national data linkage initiative to connect cardiovascular and cancer data in order to better understand the interrelationship between the two commonest caused of morbidity and mortality in the UK.

Current Patents

Cardiac assist device: EP3277337A1

The PAL-VAD device is a novel left ventricular assist device being developed with support from the British Heart Foundation

Angioplasty of calcified arteries: PCT/GB2017/050877

The Lithocatheter device is a novel angioplasty device targeting calcified coronary arteries and being developed with support of the MRC

Awards and Nominations

2021 - LAUDIX award (Papworth Hospital, Cambridge, UK)

2018 - Paul Dudley White International Scholar Award

2017 - BHF Heart Hero Award

2017 - Exceptional PPIE Engagement CRN E Mids Award

2003 - Wellcome Trust Junior Research Fellowship 1992-1998 - Scholarship of Christ Church Oxford

SELECTED RECENT PUBLICATIONS

Persu A, Lopez-Sublet M, Al-Hussaini A, Pappaccogli M, Radhouani I, Van der Niepen P, Adair W, Beauloye C, Brillet PY, Chan N, Chenu P, Devos H, Escaned J, Garcia-Guimaraes M, Hammer F, Jackson R, Jebri S, Kotecha D, Macaya F, Mahon C, Natarajan N, Neghal K, Nicol ED, Parke KS, Premawardhana D, Sajitha A, Wormleighton J, Samani NJ, McCann GP, Adlam D. Prevalence and Disease Spectrum of Extracoronary Arterial Abnormalities in Spontaneous Coronary Artery Dissection. JAMA Cardiol. 2022 Feb 1;7(2):159-166. doi: 10.1001/jamacardio.2021.4690.PMID: 34817541

Sweeting MJ, Oliver-Williams C, Teece L, Welch CA, de Belder MA, Coles B, Lambert PC, Paley L, Rutherford MJ, Elliss-Brookes L, Deanfield J, Peake MD, Adlam D;  Data Resource Profile: The Virtual Cardio-Oncology Research Initiative (VICORI) linking national English cancer registration and cardiovascular audits. VICORI Collaborative. Int J Epidemiol. 2022 Jan 6;50(6):1768-1779. doi: 10.1093/ije/dyab082.PMID: 34999882

Coles B, Teece L, Weston C, de Belder MA, Oliver-Williams C, Welch CA, Rutherford MJ, Lambert PC, Bidulka P, Paley L, Nitsch D, Deanfield J, Peake MD, Adlam D, Sweeting MJ; VICORI collaborative. Case-ascertainment of acute myocardial infarction hospitalisations in cancer patients: a cohort study using English linked electronic health data. Eur Heart J Qual Care Clin Outcomes. 2021 Jun 22:qcab045. doi: 10.1093/ehjqcco/qcab045.PMID: 34156470

Margaritis M, Saini F, Baranowska-Clarke AA, Parsons S, Vink A, Budgeon C, Alcock N, Wagner BE, Samani NJ, von der Thüsen J, Robertus JL, Sheppard MN, Adlam D. Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. Cardiovasc Res. 2021 May 28:cvab183. doi: 10.1093/cvr/cvab183.PMID: 34048532

Lozano-Prieto M, Adlam D, García-Guimaraes M, Sanz-García A, Vera-Tomé P, Rivero F, Cuesta J, Bastante T, Baranowska-Clarke AA, Vara A, Martin-Gayo E, Vicente-Manzanares M, Martín P, Samani NJ, Sánchez-Madrid F, Alfonso F, de la Fuente H. Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker. EBioMedicine. 2021 Apr;66:103338. doi: 10.1016/j.ebiom.2021.103338. Epub 2021 Apr 15.PMID: 33866193

Adlam D, Tweet MS, Gulati R, Kotecha D, Rao P, Moss AJ, Hayes SN. Spontaneous Coronary Artery Dissection: Pitfalls of Angiographic Diagnosis and an Approach to Ambiguous Cases. JACC Cardiovasc Interv. 2021 Aug 23;14(16):1743-1756. doi: 10.1016/j.jcin.2021.06.027.PMID: 34412792

Kotecha D, Garcia-Guimaraes M, Premawardhana D, Pellegrini D, Oliver-Williams C, Bountziouka V, Wood A, Natarajan N, Jackson R, Chan N, Ziaullah J, Rakhit RD, Hoole SP, Johnson TW, Kadziela J, Ludman P, Samani NJ, Maas AHEM, van Geuns RJ, Alfonso F, Adlam D. Risks and benefits of percutaneous coronary intervention in spontaneous coronary artery dissection. Heart. 2021 Sep;107(17):1398-1406. doi: 10.1136/heartjnl-2020-318914. Epub 2021 May 1

Carss KJ, Baranowska AA, Armisen J, Webb TR, Hamby SE, Premawardhana D, Al-Hussaini A, Wood A, Wang Q, Deevi SVV, Vitsios  D, Lewis SH, Kotecha D, Bouatia-Naji N, Hesselson S, Iismaa SE, Tarr I, McGrath-Cadell L, Muller DW, Dunwoodie SL, Fatkin D, Graham RM, Giannoulatou E, Samani NJ, Petrovski S, Haefliger C, Adlam D. Spontaneous Coronary Artery Dissection: Insights on rare genetic variation from genome sequencing. Circ Genom Precis Med. 2020 Dec;13(6):e003030. doi: 10.1161/CIRCGEN.120.003030. Epub 2020 Oct 30.PMID: 33125268

Verstraeten A, Perik MHAM, Baranowska AA, et al…. Persu A^,#, Adlam D^,#, Loeys B^,# Enrichment of rare variants in Loeys-Dietz syndrome genes in spontaneous coronary artery dissection but not in severe fibromuscular dysplasia. Circulation. 2020 Sep 8;142(10):1021-1024. doi: 10.1161/CIRCULATIONAHA.120.045946. Epub 2020 Sep 8.

Adlam D, Cortese B, Kadziela J. Autoimmune Disease and Spontaneous Coronary Artery Dissection: Causation Versus Coexistence. .J Am Coll Cardiol. 2020 Nov 10;76(19):2235-2237. doi: 10.1016/j.jacc.2020.09.552.PMID: 33153583

Wright JR, Chauhan M, Shah C, Ring A, Thomas AL, Goodall AH, Adlam D. The TICONC (Ticagrelor-Oncology) Study. Implications of P2Y₁₂ Inhibition for Metastasis and Cancer-Associated Thrombosis. J Am Coll Cardiol CardioOncol. 2020 Jun, 2 (2) 236-250.PMID: 34396233

Hayes SN, Tweet MS, Adlam D, Kim ESH, Gulati R, Price JE, Rose CH. Spontaneous Coronary Artery Dissection: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Aug 25;76(8):961-984. doi: 10.1016/j.jacc.2020.05.084.PMID: 32819471

Welch CA, Sweeting MJ, Lambert PC, Rutherford MJ, Jack RH, West D, Adlam D, Peake M. Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study. Br J Cancer. 2020 Aug;123(3):471-479. doi: 10.1038/s41416-020-0869-8. Epub 2020 May 11.PMID: 32390010

Al-Hussaini A, Abdelaty AMSEK, Gulsin GS, et al…Adlam D. Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management. Eur Heart J. 2020 Jun 14;41(23):2197-2205. doi: 10.1093/eurheartj/ehz895.Eur Heart J. 2020.PMID: 31898721

Jackson R, Al-Hussaini A, Joseph S, et al…Adlam D. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography. JACC Cardiovasc Imaging. 2019 Mar 8. pii: S1936-878X(19)30145-7. doi: 10.1016/j.jcmg.2019.01.015.

Adlam D, García-Guimaraes M, Maas AHEM Spontaneous coronary artery dissection: no longer a rare disease. .Eur Heart J. 2019 Apr 14;40(15):1198-1201. doi: 10.1093/eurheartj/ehz048.PMID: 30844061 

Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF. First International Consensus on the diagnosis and management of fibromuscular dysplasia. .Vasc Med. 2019 Apr;24(2):164-189. doi: 10.1177/1358863X18821816. Epub 2019 Jan 16.PMID: 30648921

Macaya F, Salinas P, Gonzalo N, Camacho-Freire SJ, Jackson R, Massot M, Ortas-Nadal MR, Sánchez-Recalde Á, Díaz-Fernández JF, Moreu J, Adlam D, Escaned J. Long-term follow-up of spontaneous coronary artery dissection treated with bioresorbable scaffolds. EuroIntervention. 2019 Jan 20;14(13):1403-1405. doi: 10.4244/EIJ-D-18-00519.PMID: 30222118

Adlam D, Olson TM, Combaret N, et al. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019 Jan 8;73(1):58-66. doi: 10.1016/j.jacc.2018.09.085.

Adlam D, Alfonso F, Maas A, Vrints C; Writing Committee. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J. 2018 Feb 22. doi: 10.1093/eurheartj/ehy080. [Epub ahead of print] No abstract available.

BOOK CHAPTERS

Adlam D Alfonso F Mass A Persu A Vrints C. Spontaneous Coronary Artery Dissection. Chapter in; The PCR - EAPCI Textbook. Percutaneous Interventional Cardiovascular Medicine. Eds. De Palma R Capranzano P.

Adlam D. The ECG in Practice 5th and 6th and 7th Editions. Ed. Hampton JR. Elsevier Ltd. 2008 2015 2019(winner of the BMJ book award (cardiology) 2009 and 150 ECG Cases 5th Edition 2019

Adlam D Prendergast BD. Angiography: Indications and limitations. Chapter in: Oxford textbook of interventional cardiology. Eds. Redwood S Curzon N Redwood M. Oxford University Press 2010 and 2nd Edition 2018

Adlam D Adnan A. Coronary artery disease and acute coronary syndrome. Chapter in ABC of arterial and venous diseases Wiley 2014

Adlam D Forfar C. Pericardial disease. Chapter in: Cardiology Medicine International Eds. Prendergast BD 2010 2015 and 2018

Adlam D. Coronary imaging. Chapter in: Cardiovascular Imaging. Ed Leeson P. Oxford University press 2011

Adlam D. Pericardial disease. Chapter in: Oxford Diagnosis and Treatment in Internal Medicine. Eds. Davey P Sprigings D. Oxford University press 2010

"https://www.bhf.org.uk/informationsupport/heart-matters-magazine/research/future-of-lvads

https://www.theengineer.co.uk/heart-pump-lvad-leicester/

http://www.bbc.co.uk/news/uk-39106357

http://www.itv.com/news/2016-02-29/new-trial-into-potentially-deadly-condition-that-affects-otherwise-healthy-women/ http://bit.ly/2mCDkt6"