Professor David Adlam

School/Department: Cardiovascular Sciences, Department of

Profile

I am an interventional cardiologist with practice in coronary stenting. Working within the Leicester NIHR Biomedical Research Centre my research interests include:

Rare cardiovascular diseases including spontaneous coronary artery dissection (SCAD) coronary aneurysms and ectasia (CAE) and fibromuscular dysplasia (FMD)
Novel medical devices
Cardio-oncology
Big data linkage to better understand disease interactions and comorbidity
Diagnosis and management of coronary artery diseases and acute myocardial infarction

Research

Selected research studies

Spontaneous Coronary Artery Dissection (SCAD): I lead the UK SCAD study currently supported by the patient charity BeatSCAD. I also chair the ESC-ACVC SCAD Study Group and the ESC-EORP SCAD registry.

The Virtual Cardio-oncology research initiative (VICORI); I am the joint lead investigator for this national data linkage initiative to connect cardiovascular and cancer data in order to better understand the interrelationship between the two commonest caused of morbidity and mortality in the UK.

Current Patents

PAL cardiac balloon support device: EP3277337A1

Angioplasty of calcified arteries: PCT/GB2017/050877

Failsafe shunt device: UK Patent application number 2211616.4

Awards and Nominations

2021 - LAUDIX award (Papworth Hospital, Cambridge, UK)

2018 - Paul Dudley White International Scholar Award

2017 - BHF Heart Hero Award

2017 - Exceptional PPIE Engagement CRN E Mids Award

2003 - Wellcome Trust Junior Research Fellowship

1992-1998 - Scholarship of Christ Church Oxford

Publications

Selected recent publications

Adlam D, Berrandou TE, Georges A, Nelson CP, Giannoulatou E, Henry J, Ma L, Blencowe M, Turley TN, Yang ML, Chopade S, Finan C, Braund PS, Sadeg-Sayoud I, Iismaa SE, Kosel ML, Zhou X, Hamby SE, Cheng J, Liu L, Tarr I, Muller DWM, d'Escamard V, King A, Brunham LR, Baranowska-Clarke AA, Debette S, Amouyel P, Olin JW, Patil S, Hesselson SE, Junday K, Kanoni S, Aragam KG, Butterworth AS; CARDIoGRAMPlusC4D; MEGASTROKE; International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group; Tweet MS, Gulati R, Combaret N; DISCO register; Kadian-Dodov D, Kalman JM, Fatkin D, Hingorani AD, Saw J, Webb TR, Hayes SN, Yang X, Ganesh SK, Olson TM, Kovacic JC, Graham RM, Samani NJ, Bouatia-Naji N. Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation. Nat Genet. 2023 Jun;55(6):964-972. doi: 10.1038/s41588-023-01410-1. Epub 2023 May 29.PMID: 37248441

Teece L, Sweeting MJ, Hall M, Coles B, Oliver-Williams C, Welch CA, de Belder MA, Deanfield J, Weston C, Rutherford MJ, Paley L, Kadam UT, Lambert PC, Peake MD, Gale CP, Adlam D; VICORI Collaborative. Impact of a Prior Cancer Diagnosis on Quality of Care and Survival Following Acute Myocardial Infarction: Retrospective Population-Based Cohort Study in England.Circ Cardiovasc Qual Outcomes. 2023 Jun;16(6):e009236. doi: 10.1161/CIRCOUTCOMES.122.009236. Epub 2023 Jun 20. PMID: 37339190

Zeymer U, Freund A, Hochadel M, Ostadal P, Belohlavek J, Rokyta R, Massberg S, Brunner S, Lüsebrink E, Flather M, Adlam D, Bogaerts K, Banning A, Sabaté M, Akin I, Jobs A, Schneider S, Desch S, Thiele H. Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials. Lancet. 2023 Aug 25:S0140-6736(23)01607-0. doi: 10.1016/S0140-6736(23)01607-0. Online ahead of print. PMID: 37643628

Chan N, Premawardhana D, Al-Hussaini A, Wood A, Bountziouka V, Kotecha D, Swahn E, Palmefors H, Pagonis C, Sederholm Lawesson S, Kądziela J, Garcia-Guimarães M, Alfonso F, Escaned J, Macaya F, Santás M, Cerrato E, Maas AHEM, Hlinomaz O, Bogale N, Cortese B, Cheng M, Bolger A, Hussain ST, Samani NJ, Knight M, Cauldwell M, Adlam D. Pregnancy and Spontaneous Coronary Artery Dissection: Lessons From Survivors and Nonsurvivors. Circulation. 2022 Jul 5;146(1):69-72. doi: 10.1161/CIRCULATIONAHA.122.059635. Epub 2022 Jun 3. PMID: 35656808

Persu A, Lopez-Sublet M, Al-Hussaini A, Pappaccogli M, Radhouani I, Van der Niepen P, Adair W, Beauloye C, Brillet PY, Chan N, Chenu P, Devos H, Escaned J, Garcia-Guimaraes M, Hammer F, Jackson R, Jebri S, Kotecha D, Macaya F, Mahon C, Natarajan N, Neghal K, Nicol ED, Parke KS, Premawardhana D, Sajitha A, Wormleighton J, Samani NJ, McCann GP, Adlam D. Prevalence and Disease Spectrum of Extracoronary Arterial Abnormalities in Spontaneous Coronary Artery Dissection. JAMA Cardiol. 2022 Feb 1;7(2):159-166. doi: 10.1001/jamacardio.2021.4690.PMID: 34817541

Margaritis M, Saini F, Baranowska-Clarke AA, Parsons S, Vink A, Budgeon C, Alcock N, Wagner BE, Samani NJ, von der Thüsen J, Robertus JL, Sheppard MN, Adlam D. Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. Cardiovasc Res. 2022 Jun 22;118(7):1835-1848. doi: 10.1093/cvr/cvab183. PMID: 34048532

Carss KJ, Baranowska AA, Armisen J, Webb TR, Hamby SE, Premawardhana D, Al-Hussaini A, Wood A, Wang Q, Deevi SVV, Vitsios D,Lewis SH,Kotecha D, Bouatia-Naji N, Hesselson S, Iismaa SE, Tarr I, McGrath-Cadell L, Muller DW, Dunwoodie SL, Fatkin D, Graham RM, Giannoulatou E, SamaniNJ, Petrovski S, Haefliger C, Adlam D. Spontaneous Coronary Artery Dissection: Insights on rare genetic variation from genome sequencing. Circ Genom Precis Med. 2020 Dec;13(6):e003030. doi: 10.1161/CIRCGEN.120.003030. Epub 2020 Oct 30. PMID: 33125268

Al-Hussaini A, Abdelaty AMSEK, Gulsin GS, Arnold JR, Garcia-Guimaraes M, Premawardhana D, Budgeon C, Wood A, Natarajan N, Mangion K, Rakhit R, Hoole SP, Johnson TW, Berry C, Hudson I, Gershlick AH, Ladwiniec A, Kovac J, Squire I, Samani NJ, Plein S, McCann GP, Adlam D. Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management. Eur Heart J. 2020 Jun 14;41(23):2197-2205. doi: 10.1093/eurheartj/ehz895.Eur Heart J. 2020.PMID: 31898721

Verstraeten A, Perik MHAM, Baranowska AA, Meester JAN, Van Den Heuvel L, Bastianen J, Kempers M, Krapels IPC, Maas A, Rideout A, Vandersteen A, Sobey G, Johnson D, Fransen E, Ghali N, Webb T, Al-Hussaini A, de Leeuw P, Delmotte P, Lopez-Sublet M, Pappaccogli M, Sprynger M, Toubiana L; European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI); Van Laer L, Van Dijk FS, Vikkula M, Samani NJ, Persu A, Adlam D, Loeys B; Collaborators of the European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI). Enrichment of Rare Variants in Loeys-Dietz Syndrome Genes in Spontaneous Coronary Artery Dissection but Not in Severe Fibromuscular Dysplasia. Circulation. 2020 Sep 8;142(10):1021-1024. doi: 10.1161/CIRCULATIONAHA.120.045946. Epub 2020 Sep 8. PMID: 32897753

Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O'Byrne MM, Bouajila S, Georges A, Mishra K, Braund PS, d'Escamard V, Huang S, Margaritis M, Nelson CP, de Andrade M, Kadian-Dodov D, Welch CA, Mazurkiewicz S, Jeunemaitre X; DISCO Consortium, Wong CMY, Giannoulatou E, Sweeting M, Muller D, Wood A, McGrath-Cadell L, Fatkin D, Dunwoodie SL, Harvey R, Holloway C, Empana JP, Jouven X; CARDIoGRAMPlusC4D Study Group, Olin JW, Gulati R, Tweet MS, Hayes SN, Samani NJ, Graham RM, Motreff P, Bouatia-Naji N. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019 Jan 8;73(1):58-66. doi: 10.1016/j.jacc.2018.09.085.q

Jackson R, Al-Hussaini A, Joseph S, van Soest G, Wood A, Macaya F, Gonzalo N, Cade J, Caixeta A, Hlinomaz O, Leinveber P, O'Kane P, García-Guimaraes M, Cortese B, Samani NJ, Escaned J, Alfonso F, Johnson T, Adlam D. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography. JACC Cardiovasc Imaging. 2019 Dec;12(12):2475-2488. doi: 10.1016/j.jcmg.2019.01.015. Epub 2019 Mar 13. PMID: 30878439

Adlam D, Alfonso F, Maas A, Vrints C; Writing Committee. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J. 2018 Feb 22. doi: 10.1093/eurheartj/ehy080.

Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. Circulation. 2018 May 8;137(19):e523-e557. doi: 10.1161/CIR.0000000000000564. Epub 2018 Feb 22.

Supervision

Candidates interested in working towards either MD or PhD either preclinically or clinically should contact me directly on da134@le.ac.uk.

Teaching

I support medical education of both preclinical, clinical and post graduate students

Interests

Book chapter

Adlam D Alfonso F Mass A Persu A Vrints C. Spontaneous Coronary Artery Dissection. Chapter in; The PCR - EAPCI Textbook. Percutaneous Interventional Cardiovascular Medicine. Eds. De Palma R Capranzano P

Adlam D. The ECG in Practice 5th and 6th and 7th Editions. Ed. Hampton JR. Elsevier Ltd. 2008 2015 2019(winner of the BMJ book award (cardiology) 2009 and 150 ECG Cases 5th Edition 2019

Adlam D Prendergast BD. Angiography: Indications and limitations. Chapter in: Oxford textbook of interventional cardiology. Eds. Redwood S Curzon N Redwood M. Oxford University Press 2010 and 2nd Edition 2018

Adlam D Adnan A. Coronary artery disease and acute coronary syndrome. Chapter in ABC of arterial and venous diseases Wiley 2014

Adlam D Forfar C. Pericardial disease. Chapter in: Cardiology Medicine International Eds. Prendergast BD 2010 2015 and 2018

Adlam D. Coronary imaging. Chapter in: Cardiovascular Imaging. Ed Leeson P. Oxford University press 2011

Adlam D. Pericardial disease. Chapter in: Oxford Diagnosis and Treatment in Internal Medicine. Eds. Davey P Sprigings D. Oxford University press 2010

Media coverage

Qualifications

BA BM BCh DPhil FRCP FESC