People

Professor Jonathan Thompson

Hon Professor of Anaesthesia and Critical Care

Profile

Senior Lecturer/Hon Consultant University of Leicester and University Hospitals of Leicester NHS Trust from 1997- 2015 and Hon Professor in anaesthesia and critical care since 2016. Currently: Senior undergraduate clinical education lead, UHL and UoL; elected council member Royal College of Anaesthetists; editor-in-chief BJA Education; editorial board member British Journal of Anaesthesia & Perioperative Medicine; expert advisor to the Royal Pharmaceutical Society; and co-director Diagnostics Development Unit University of Leicester. Previously: editor British Journal of Anaesthesia (2008-2017); Macintosh Professor of the Royal College of Anaesthetists (2011); a member of the European Society of Anaesthesiologists Pharmacology Subcommittee; ChairmanVascular Anaesthesia Society of Great Britain and Ireland; examiner for the Primary FRCA (2007-2020). Invited lectures:World Congress of Anaesthesiologists European Society of Anaesthesiologists Japanese Society of Intensive Care Medicine Irish National Congress of Anaesthesia Chinese Society of Anesthesiologists European Vascular & Endovascular Society International Regulatory Peptide Society South African Society of Anaesthesiology and many national meetings in the UK 

Research

Led clinical research in anaesthesia and critical care teams in Leicester and the East Midlands for over 18 years. Research collaborations in Leicester Italy Japan and Brazil. Current research interests include: novel non-invasive monitoring modalities in acute illness; the effects of endogenous opioids on vascular function and immune modulation in sepsis.

Publications

(0) 3 textbooks; 76 original research papers; 10 reviews; 30 book chapters; 34 educational articles; 9 editorials. h-index 31: Research Gate score 39.94
Selected publications:
Original research:

Lim C, De Silva I, Moussa G, Islam T, Osman L, Malick H, Youssef M, Farrag A, Ashraf R, Deol S, Burgula S, Thompson JP. Redeployment of ophthalmologists in the United Kingdom during the Coronavirus Disease Pandemic. Eur J Ophthalmology 2021; 31,5: 2268-2274

Charlton M, Stanley SA, Whitman Z, Wenn V, Coats TJ, Sims MR, Thompson JP. The effect of constitutive pigmentation on the measured emissivity of human skin. PLOS One November 2020;

Dominguini D, Michels M, Ritter, C, Barichello T, Thompson JP, dal Pizzol F.The effects of anaesthetics and sedatives on brain inflammation, in Neuroscience & Biobehavioral Reviews 2021; 127:404-13

Koeckerling D, Barker J, Mudalige NL, Oyefeso O, Pan D, Pareek M, Thompson JP, Ng A. Awake Prone Positioning in COVID-19. Thorax 2020 

Bird MF, Guerrini R, Willets J, Thompson JP, Calo G, Lambert DG. Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594; a novel fluorescent probe for the NOP receptor.  Br J Pharmacol 2018; 175 (24):4496-4506

Al-Hashimi M Thompson JP, Lambert DG. Evidence for NOP, but not MOP DOP or KOP opioid receptor mRNA in whole human blood. Br J Anaes 2016; 116: 423-9

Scott SW, Batchelder AJ, Kirkbride D, Naylor AR, Thompson JP. Late survival in non-operated patients with infra-renal abdominal aortic aneurysm.  Eur J Vasc Endovasc Surg. 2016;  52, 444-449

Stover CM, McDonald J, Byrne S, Lambert DG, Thompson JP. Properdin levels in human sepsis.  Frontiers Immunol 2015; 6,24

Thompson JP, Serrano-Gomez A, Ladak N, Bowrey S, McDonald J, Lambert DG. The Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass. PLOS One 2013 Oct 4;8(10):e76682.

McDonald J, Leonard AD, Serrano-Gomez A, Young SP, Swanevelder J, Thompson JP, Lambert DG. Assessment of nociceptin/orphanin FQ and mu-opioid receptor mRNA in the human right atrium. British Journal of Anaesthesia 2010; 104:698-704

Williams JP, Thompson JP, Young SP, Gold SJ, McDonald J, Rowbotham DJ, Lambert DG. Nociceptin and urotensin-II concentrations in critically ill patients with sepsis.  British Journal of Anaesthesia 2008; 100: 810-814 

Williams JP, Thompson JP, McDonald J et al.  Human Peripheral Blood Mononuclear Cells Express Nociceptin/Orphanin FQ But Not µ, d or k Opioid Receptors.  Anesth Analg 2007;105: 998-1005 

Prudon B, Birring SD, Vara DD, Hall AP, Thompson JP, Pavord ID. Cough and glottic stop reflex sensitivity in health and disease. Chest 2005; 127: 550-7

Cowley E, Thompson JP, Sharpe P, Waugh J, Ali N, Lambert DG. Effects of pre-eclampsia on maternal plasma, cerebrospinal fluid & umbilical cord Urotensin II concentrations. Br J Anaes 2005; 95: 495-9 

Maguire A, Kumar N, Parker J, Rowbotham DJ, Thompson JP. Comparison of the effects of remifentanil and alfentanil on the cardiovascular response to tracheal intubation in hypertensive patients. Br J Anaes 2001; 86: 90-93 

Boyle JR, Goodall S, Thompson JP, Bell PRF, Thompson MM.  Endovascular AAA repair attenuates the inflammatory and renal responses associated with conventional surgery.  J Endovascular Therapy 2000; 7: 359-371

Hall AP, Thompson JP, Leslie NA, Fox AJ, Kumar N, Rowbotham DJ. Comparison of different doses of remifentanil on the cardiovascular response to laryngoscopy and tracheal intubation. Br J Anaes 2000, 84: 100-2

Thompson JP, Boyle JR, Thompson MM, Strupish J, Bell PRF, Smith G. Cardiovascular & catecholamine responses during endovascular &conventional abdominal aortic aneurysm repair. Eur J Vascular  Endovasc Surg 1999; 17: 326-333

Thompson JP, Hall AP, Russell J, Cagney B, Rowbotham DJ. The effect of remifentanil upon the haemodynamic response to orotracheal intubation. Br J Anaes 1998; 80: 467-469

Thompson JP, Bower S, Liddle AM, Rowbotham DJ. Perioperative pharmacokinetics of transdermal fentanyl in elderly and young adult patients. Br J Anaes 1998; 81: 152-154 

Thompson MM, Nasim A, Sayers RD, Thompson JP et al. Oxygen free radical & cytokine generation during endovascular & conventional abdominal aortic aneurysm repair. Eur J Vascular  Endovasc Surg 1996; 12: 70-75

Thompson J.P., Palmer R.L., Petersen S.A.  Is there a metabolic component to counter- regulation? International Journal of Eating Disorders 1988; 7: 307-319 

Edited volumes:

Thompson JP, Murphy PG, Bodenham AR. Diagnosis of death and organ donation.British Journal of Anaesthesia 108, Suppl 1, Jan 2012

Irwin MG, Thompson JP, Howell SJ.Current Challenges in Vascular Anaesthesia. British Journal of Anaesthesia 117, Issue Suppl 2, Sept 2016

Textbooks:

Thompson JP Moppett IG Wiles M (eds) Smith & Aitkenhead’s Textbook of Anaesthesia 7th edn Elsevier, Edinburgh (2019)

Aitkenhead AR, Moppett IG, Thompson JP (Eds) Smith and Aitkenhead’s Textbook of Anaesthesia. 6th edn. Churchill Livingstone Elsevier, Edinburgh (2013)

Thompson JP, Telford RJ, Howell SJ (Eds) Oxford Specialist Handbook of vascular anaesthesia, Oxford University Press, Oxford (2014)

 
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Supervision

Critical Care; opioids; sepsis; anaesthesia

Teaching

Senior Undergraduate Clinical Education Lead, UHL and UoL. Regular invited talks at national and international scientific/educational postgraduate meetings (France Denmark Portugal Europe South Africa Brazil) Local teaching to undergraduates & trainee anaesthetists on perioperative and critical care Educational supervisor to 2 trainees in Intensive Care Medicine Clinical & academic supervisor for matched honorary lecturers intercalated BSc students academic foundation doctors. Course Director & tutor for the Leicester FRCA revision courses 1997-2016 

Press and media

Critical Care and perioperative medicine as permitted by UHL

Activities

Elected council member Royal College of Anaesthetists since 2020 Editor-in-chief BJA Education since 2018 Editorial board member British Journal of Anaesthesia (since 2005) Perioperative Medicine (since 2011) RCoA Bulletin (since 2020) Expert advisor to the Royal Pharmaceutical Society since 2007 Co-director Diagnostics Development Unit University of Leicester since 2014 Previously: editor British Journal of Anaesthesia (2008-17); member of the European Society of Anaesthesiologists Pharmacology Subcommittee (2006-12); ChairmanVascular Anaesthesia Society of Great Britain and Ireland (2007-10); examiner for the Primary FRCA for the Royal College of Anaesthetists (2007-20). UHL Clinical Lead for organ donation (CLOD) 2014-18 and regional CLOD for the Midlands 2015-18 Chair of the Trial Steering Committee for the ACCEPTS trial (University of Nottingham 2018 to date) and a member of the Trial Steering Committee for the SOS trial (Warwick Clinical Trials Unit 2019 to date). 

Awards

Macintosh Professor of the Royal College of Anaesthetists (2011) Invited lectures: Keynote international speaker Japanese Society of Intensive Care Medicine Hirosaki Japan June 2011 Invited speaker European Society of Anaesthesiologists 2008 2010 2011 2012 2013 2018; World Congress of Anaesthesiologists 2008; Irish National Congress of Anaesthesia 2011; Chinese Society of Anesthesiologists 2013; European Vascular & Endovascular Meeting Maastricht 2014; International Regulatory Peptides Annual Meeting Rouen 2016; SASA meeting Pretoria 2020 and many national meetings in the UK

Qualifications

BSc (Hons) MB ChB MD FRCA FFICM
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