Professor Leong Ng

Leong Ng studied medicine at University of Cambridge with an Entrance and Senior scholarship at Trinity College. He was MRC fellow at the Radcliffe Infirmary Oxford and lecturer in Clinical Pharmacology before taking up a Senior Lectureship in Clinical Pharmacology at the University of Leicester. He subsequently became Professor of Medicine and Therapeutics and headed the Clinical Pharmacology division. He is currently the Precision Medicine theme lead for the NIHR Leicester Biomedical Research Centre.

His research involves use of omic and bioinformatic technologies for discovery and targeting of biomarkers in cardiovascular disease for diagnosis prognosis and monitoring of therapy. This research has been in the fields of hypertension heart failure ischaemic heart disease and valvular disease and has been funded by the BHF MRC NIHR EU and the Van Geest trust.

Tromp J, Ouwerkerk W, Demissei BG, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, Voors AA, van der Meer P. Novel endotypes in heart failure: effects on guideline-directed medical therapy. Eur Heart J. 2018;39(48):4269-4276. 

Tromp J, Westenbrink BD, Ouwerkerk W, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Lang CC, Ng LL, Zannad F, Zwinderman AH, Hillege HL, van der Meer P, Voors AA. Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction. J Am Coll Cardiol. 2018;72(10):1081-1090. 

Santema BT, Kloosterman M, Van Gelder IC, Mordi I, Lang CC, Lam CSP, Anker SD, Cleland JG, Dickstein K, Filippatos G, Van der Harst P, Hillege HL, Ter Maaten JM, Metra M, Ng LL, Ponikowski P, Samani NJ, Van Veldhuisen DJ,  Zwinderman AH, Zannad F, Damman K, Van der Meer P, Rienstra M, Voors AA. Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction. Eur Heart J. 2018;39(43):3867-3875. 

Ouwerkerk W, Zwinderman AH, Ng LL, Demissei B, Hillege HL, Zannad F, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Ter Maaten JM, Lang CC, van der Harst P, Filippatos G, Dickstein K, Cleland JG, Anker SD, Voors AA. Biomarker- Guided Versus Guideline-Based Treatment of Patients With Heart Failure: Results From BIOSTAT-CHF. J Am Coll Cardiol. 2018;71(4):386-398. 

Suzuki T, Israr MZ, Heaney LM, Takaoka M, Squire IB, Ng LL. Prognostic Role of Molecular Forms of B-Type Natriuretic Peptide in Acute Heart Failure. Clin Chem. 2017;63(4):880-886. 

Ng LL, Squire IB, Jones DJL, Cao TH, Chan DCS, Sandhu JK, Quinn PA, Davies JE, Struck J, Hartmann O, Bergmann A, Mebazaa A, Gayat E, Arrigo M, Akiyama E, Sabti Z, Lohrmann J, Twerenbold R, Herrmann T, Schumacher C, Kozhuharov N, Mueller C; GREAT Network. Proenkephalin, Renal Dysfunction, and Prognosis in Patients With Acute Heart Failure: A GREAT Network Study. J Am Coll Cardiol. 2017;69(1):56-69. 

Suzuki T, Heaney LM, Bhandari SS, Jones DJ, Ng LL. Trimethylamine N-oxide and prognosis in acute heart failure. Heart. 2016;102(11):841-8.

Van der Wal HH, Grote Beverborg N, Dickstein K, Anker SD, Lang CC, Ng LL, van Veldhuisen DJ, Voors AA, van der Meer P. Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use. Eur Heart J. 2019;40(44):3616-3625.

Santema BT, Ouwerkerk W, Tromp J, Sama IE, Ravera A, Regitz-Zagrosek V, Hillege H, Samani NJ, Zannad F, Dickstein K, Lang CC, Cleland JG, Ter Maaten JM, Metra M, Anker SD, van der Harst P, Ng LL, van der Meer P, van Veldhuisen DJ, Meyer S, Lam CSP; ASIAN-HF investigators, Voors AA. Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study. Lancet. 2019;394(10205):1254-1263. 

Gupta P, Voors AA, Patel P, Lane D, Anker SD, Cleland JGF, Dickstein K, Filippatos G, Lang CC, van Veldhuisen DJ, Metra M, Zannad F, Samani NJ, Jones DJL, Squire IB, Ng LL. Non-adherence to heart failure medications predicts clinical outcomes: assessment in a single spot urine sample by liquid chromatography-tandem mass spectrometry (results of a prospective multicentre study). Eur J Heart Fail. 2021 Mar 23. doi: 10.1002/ejhf.2160. PMID: 33759308.

Discovery and targetting of proteomic and metabolomic biomarkers in cardiovascular disease including heart failure coronary artery and valvular heart disease. Pathophysiological mechanisms in cardiovascular disease.

MSc Cardiovascular Disease/Precision Medicine

Biomarkers

MA (Cantab) MB BChir MD (Cantab) FRCP (London) FBPhS FHEA