I completed my PhD at the University of Tübingen followed by a postdoc in Prof. Viki Allan’s lab in Mancheter. Before moving to Leicester I worked as a research scientist in the NHSBT.
My research focuses on aspects of organ injury in cardiac surgery patients:
• Novel biomarker discovery for acute kidney injury;
• Mechanisms underlying endothelial dysfunction in AKI;
• Obesity paradox.
We use a range of techniques that includes the next generation sequencing flow cytometry microscopy-based in vitro models of inflammation and combine it with bioinformatics and statistical analysis.
We are supported by the British Heart Foundation NIHR Cardiovascular Biomedical Research Unit and Van Geest Heart and Cardiovascular Diseases Research Fund
(0) 1. Roman MA, Abbasciano RG, Pathak S, Oo S, Yusoff S, Wozniak M, Qureshi S, Lai FY, Kumar T, Richards T, Yao G, Estcourt L, Murphy GJ. Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis. Br J Anaesth. 2021 Jan;126(1):149-156. doi: 10.1016/j.bja.2020.04.087.
2. Pathak S, Olivieri G, Mohamed W, Abbasciano R, Roman M, Tomassini S, Lai F, Wozniak M, Murphy GJ. Pharmacological interventions for the prevention of renal injury in surgical patients: a systematic literature review and meta-analysis. Br J Anaesth. 2021 Jan;126(1):131-138. doi: 10.1016/j.bja.2020.06.064.
3. WoÅºniak MJ, Abbasciano R, Monaghan A, Lai FY, Corazzari C, Tutino C, Kumar T, Whiting P, Murphy GJ. Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies Evaluating Point-of-Care Tests of Coagulopathy in Cardiac Surgery. Transfus Med Rev. 2021 Jan;35(1):7-15. doi: 10.1016/j.tmrv.2020.09.012.
4. Kumar T, Aujla H, WoÅºniak M, Dott W, Sullo N, Joel-David L, Pais P, Smallwood D, Miller D, Eagle-Hemming B, Di Paola AS, Barber S, Brookes C, Brunskill NJ, Murphy GJ. Intravenous sildenafil citrate and post-cardiac surgery acute kidney injury: a double-blind, randomised, placebo-controlled trial. Br J Anaesth. 2020 Jun;124(6):693-701. doi: 10.1016/j.bja.2020.01.030.
5. Pais P, Robinson S, Majithia-Beet G, Lotto A, Kumar T, Westrope C, Sullo N, Eagle Hemming B, Joel-David L, JnTala M, Corazzari C, Grazioli L, Smallwood D, Murphy GJ, Lai FY, WoÅºniak MJ. Biomarkers of Inflammation and Lung Recovery in Extracorporeal Membrane Oxygenation Patients With Persistent Pulmonary Hypertension of the Newborn: A Feasibility Study. Pediatr Crit Care Med. 2020 Apr;21(4):363-372. doi: 10.1097/PCC.0000000000002173.
6. Yusoff SI, Roman M, Lai FY, Eagle-Hemming B, Murphy GJ, Kumar T, Wozniak M. Systematic review and meta-analysis of experimental studies evaluating the organ protective effects of histone deacetylase inhibitors. Transl Res. 2019 Mar;205:1-16. doi: 10.1016/j.trsl.2018.11.002.
7. Sullo N, Mariani S, JnTala M, Kumar T, WoÅºniak MJ, Smallwood D, Pais P, Westrope C, Lotto A, Murphy GJ. An Observational Cohort Feasibility Study to Identify Microvesicle and Micro-RNA Biomarkers of Acute Kidney Injury Following Pediatric Cardiac Surgery. Pediatr Crit Care Med. 2018 Sep;19(9):816-830. doi: 10.1097/PCC.0000000000001604.
8. WoÅºniak MJ, Qureshi S, Sullo N, Dott W, Cardigan R, Wiltshire M, Nath M, Patel NN, Kumar T, Goodall AH, Murphy GJ. A Comparison of Red Cell Rejuvenation versus Mechanical Washing for the Prevention of Transfusion-associated Organ Injury in Swine. Anesthesiology. 2018 Feb;128(2):375-385. doi: 10.1097/ALN.0000000000001973.
9. Wozniak MJ, Sullo N, Qureshi S, Dott W, Cardigan R, Wiltshire M, Morris T, Nath M, Bittar N, Bhudia SK, Kumar T, Goodall AH, Murphy GJ. Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery. Br J Anaesth. 2017 May 1;118(5):689-698. doi: 10.1093/bja/aex083.
10. Mariscalco G, Wozniak MJ, Dawson AG, Serraino GF, Porter R, Nath M, Klersy C, Kumar T, Murphy GJ. Body Mass Index and Mortality Among Adults Undergoing Cardiac Surgery: A Nationwide Study With a Systematic Review and Meta-Analysis. Circulation. 2017 Feb 28;135(9):850-863. doi: 10.1161/CIRCULATIONAHA.116.022840.
Departmental coordinator for undergraduate third year projects.
BSc/MSc (Biotechnology) 1999 University of Wroclaw Poland
PhD 2003 University of Tübingen Germany