People

Dr Marcin Wozniak

Lecturer

School/Department: Cardiovascular Sciences, Department of

Telephone: +44 (0)116 258 3028

Email: mw299@leicester.ac.uk

Profile

I completed my PhD at the University of Tübingen followed by a postdoc in Prof. Viki Allan’s lab in Mancheter. Before moving to Leicester I worked as a research scientist in the NHSBT.

Research

My research focuses on aspects of organ injury in cardiac surgery patients: • Novel biomarker discovery for acute kidney injury; • Mechanisms underlying endothelial dysfunction in AKI; • Multimorbidity; • Obesity paradox. We use a range of techniques that includes the next generation sequencing flow cytometry microscopy-based in vitro models of inflammation and combine it with bioinformatics and statistical analysis. We are supported by the British Heart Foundation NIHR Cardiovascular Biomedical Research Unit and Van Geest Heart and Cardiovascular Diseases Research Fund 

Publications

(0) 1. Roman MA, Abbasciano RG, Pathak S, Oo S, Yusoff S, Wozniak M, Qureshi S, Lai FY, Kumar T, Richards T, Yao G, Estcourt L, Murphy GJ. Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis. Br J Anaesth. 2021 Jan;126(1):149-156. doi: 10.1016/j.bja.2020.04.087. 
2. Pathak S, Olivieri G, Mohamed W, Abbasciano R, Roman M, Tomassini S, Lai F, Wozniak M, Murphy GJ. Pharmacological interventions for the prevention of renal injury in surgical patients: a systematic literature review and meta-analysis. Br J Anaesth. 2021 Jan;126(1):131-138. doi: 10.1016/j.bja.2020.06.064. 
3. Woźniak MJ, Abbasciano R, Monaghan A, Lai FY, Corazzari C, Tutino C, Kumar T, Whiting P, Murphy GJ. Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies Evaluating Point-of-Care Tests of Coagulopathy in Cardiac Surgery. Transfus Med Rev. 2021 Jan;35(1):7-15. doi: 10.1016/j.tmrv.2020.09.012. 
4. Kumar T, Aujla H, Woźniak M, Dott W, Sullo N, Joel-David L, Pais P, Smallwood D, Miller D, Eagle-Hemming B, Di Paola AS, Barber S, Brookes C, Brunskill NJ, Murphy GJ. Intravenous sildenafil citrate and post-cardiac surgery acute kidney injury: a double-blind, randomised, placebo-controlled trial. Br J Anaesth. 2020 Jun;124(6):693-701. doi: 10.1016/j.bja.2020.01.030. 
5. Pais P, Robinson S, Majithia-Beet G, Lotto A, Kumar T, Westrope C, Sullo N, Eagle Hemming B, Joel-David L, JnTala M, Corazzari C, Grazioli L, Smallwood D, Murphy GJ, Lai FY, Woźniak MJ. Biomarkers of Inflammation and Lung Recovery in Extracorporeal Membrane Oxygenation Patients With Persistent Pulmonary Hypertension of the Newborn: A Feasibility Study. Pediatr Crit Care Med. 2020 Apr;21(4):363-372. doi: 10.1097/PCC.0000000000002173. 
6. Yusoff SI, Roman M, Lai FY, Eagle-Hemming B, Murphy GJ, Kumar T, Wozniak M. Systematic review and meta-analysis of experimental studies evaluating the organ protective effects of histone deacetylase inhibitors. Transl Res. 2019 Mar;205:1-16. doi: 10.1016/j.trsl.2018.11.002. 
7. Sullo N, Mariani S, JnTala M, Kumar T, Woźniak MJ, Smallwood D, Pais P, Westrope C, Lotto A, Murphy GJ. An Observational Cohort Feasibility Study to Identify Microvesicle and Micro-RNA Biomarkers of Acute Kidney Injury Following Pediatric Cardiac Surgery. Pediatr Crit Care Med. 2018 Sep;19(9):816-830. doi: 10.1097/PCC.0000000000001604. 
8. Woźniak MJ, Qureshi S, Sullo N, Dott W, Cardigan R, Wiltshire M, Nath M, Patel NN, Kumar T, Goodall AH, Murphy GJ. A Comparison of Red Cell Rejuvenation versus Mechanical Washing for the Prevention of Transfusion-associated Organ Injury in Swine. Anesthesiology. 2018 Feb;128(2):375-385. doi: 10.1097/ALN.0000000000001973. 
9. Wozniak MJ, Sullo N, Qureshi S, Dott W, Cardigan R, Wiltshire M, Morris T, Nath M, Bittar N, Bhudia SK, Kumar T, Goodall AH, Murphy GJ. Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery. Br J Anaesth. 2017 May 1;118(5):689-698. doi: 10.1093/bja/aex083. 
10. Mariscalco G, Wozniak MJ, Dawson AG, Serraino GF, Porter R, Nath M, Klersy C, Kumar T, Murphy GJ. Body Mass Index and Mortality Among Adults Undergoing Cardiac Surgery: A Nationwide Study With a Systematic Review and Meta-Analysis. Circulation. 2017 Feb 28;135(9):850-863. doi: 10.1161/CIRCULATIONAHA.116.022840. 

 
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Supervision

Current PhD projects: Metabolic stress in the pathology of organ injury after cardiac surgery. (Miss Sophia Sheikh) The role of iron metabolism and mitochondrial function in frailty and the obesity paradox. (Miss Kristina Tomkova) Micro RNAs and fibrosis progression in asymptomatic Aortic Stenosis: towards an integrated imaging and biomarker precision medicine approach to risk satisfaction. (Ms Oseka Adewuyi) Characterisation of Urinary miRNA profiles of Patients in the REVAKI-2 Trial. A study to identify molecular markers of acute kidney injury in Cardiac Surgery Patients. (Mr Doug Miller) 

Teaching

Departmental coordinator for undergraduate third year projects.

Press and media

Cardiovascular biomarkers

Qualifications

BSc/MSc (Biotechnology) 1999 University of Wroclaw Poland PhD 2003 University of Tübingen Germany
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