Example PhD projects

Self-funding students or students seeking PhD studentship opportunities are encouraged to view the example projects offered below by supervisors in our department. If you are interested, please contact the relevant supervisor for each project.

In the case of supervisors or co-supervisors who work in other departments, their main department is denoted in parentheses following their name.

Project Supervisor Co-supervisor
The Effect of Surgery on Central Aortic Pressure and Haemodynamics (ESCAPE) Professor Matt Bown Professor Rob Sayers
An investigation into unstable carotid atherosclerotic plaques  Professor Rob Sayers/Professor A Ross Naylor Professor Matt Bown
Engineering a novel angiogenic ligand for regenerative medicine purposes  Professor Nick Brindle Professor Nick J M London (Leicester Medical School)
Protein engineering the angiopoietin receptor ectodomain   Professor Nick Brindle Dr Dave Lodwick
Readdressing Receptor Ligands  Professor Nick Brindle Dr Karl E Herbert
Mitochondrial Reactive Oxygen Species Signalling and Cardiovascular Disease Mechanisms Dr Karl E Herbert Professor Alison H Goodall
Modulation of vascular endothelial cell phenotype by the senescence secretome  Dr Karl E Herbert Dr Salvador Macip (Department of Molecular and Cell Biology)
Evaluating cellular and genetic factors regulating the haemostatic response in patients with cardiovascular disease and healthy controls Professor Alison H Goodall Dr James Burton (Department of Infection, Immunity and Inflammation)
Is platelet-derived microRNA a modifiable risk factor in patients with acute coronary syndrome? Professor Alison H Goodall Dr J Howard Pringle (Leicester Cancer Research Centre)
Is platelet-mediated gene expression in monocytes regulated by aspirin via the PPAR gamma pathway? Professor Alison H Goodall Professor John Schwabe (Department of Molecular and Cell Biology)
The role of the sarcolemmal KATp channel in ischaemia Dr Richard Rainbow Dr Dave Lodwick
Effects of hyperglycaemia and glucose-lowering therapies on cardiac function: in-vitro modelling of ischaemia and ischaemic preconditioning in isolated ventricular myocytes Dr Glenn Rodrigo Dr Richard Rainbow/Professor Iain B Squire
Re-modelling of the b-adrenoreceptor pathway and diurnal variation in sudden cardiac death in ventricular heart failure: role of NOS signalling Dr Glenn Rodrigo Professor Iain B Squire
Remote ischaemic postconditioning of human myocardium during ischaemic disease Dr Glenn Rodrigo Professor Sir Nilesh J Samani
Does cardiac conditioning modify ventricular re-modelling following AMI? Dr Glenn Rodrigo Professor Sir Nilesh J Samani
A mesenchymal stem cell-based approach for investigating cardiovascular disease-related genetic variants Professor Sir Nilesh J Samani Dr Dave Lodwick/Dr Tom Webb
Generation of Isogenic Cell Lines, Using Genome Editing, to Investigate Genetic Variants Associated with Coronary Artery Disease Professor Sir Nilesh J Samani Dr Dave Lodwick/Dr Tom Webb
Functional analysis of novel genetic markers of coronary artery disease identified by genome-wide association studies Professor Sir Nilesh J Samani Dr Maciej Tomaszewski
Genome editing-induced pluripotent stem cells models of biological ageing  Dr Tom Webb Professor Sir Nilesh J Samani/ Dr Veryan Codd
The 14q32 CAD risk locus: functional analysis of HHIPL1 Dr Tom Webb Dr E Stringer
Molecular mechanism of atrial fibrillation at the chromosome 4q25 locus  Dr P Ellinor/Dr D Milan Professor Sir Nilesh J Samani
Pamp-induced inflammatory reactions in CDLR/Properdin-deficient mice Dr Clett Erridge Dr Cordula Stover (Department of Infection, Immunity and Inflammation)
Autonomic modulation of ventricular arrhythmia is heart failure Professor G André Ng Dr K E Brack
Improving understanding and treatment of AF via ablation: The frequency domain, objective measurements of fractionation and entropy Professor G André Ng Dr Fernando Soares Schlindwein (Department of Engineering)
Signal processing of atrial electrograms of patients with atrial fibrillation (AF) Dr Fernando Soares Schlindwein (Department of Engineering) Professor G André Ng
Non-invasive transmural 3-dimensional mapping of atrial fibrillation for catheter ablation Dr Fernando Soares Schlindwein (Department of Engineering) Professor G André Ng
The Plasma Proteome and outcome in patients with heart failure Professor Leong Loke Ng Professor Don J L Jones (Leicester Cancer Research Centre)
The impact of ethnicity and High Density Lipoprotein proteome Professor Leong Loke Ng Professor Don J L Jones (Leicester Cancer Research Centre)
Markers of Heart Failure Professor Don J L Jones (Leicester Cancer Research Centre) Professor Leong Loke Ng
Myocardial Perfusion reserve in Aortic Stenosis  Professor Gerry McCann Dr M Horsfield
Identifying the vulnerable carotid plaque by dynamic ultrasound imaging and image texture analysis Dr M Horsfield Dr Kumar Ramnarine/Professor Thompson G Robinson
Navigation of emboli and wireless magnetic microvascular devices through the vasculature; a feasibility study Dr Emma Chung Dr M Horsfield
Emboli-induced brain injury following cardiac surgery  Dr Emma Chung Dr M Horsfield
Effects of ischaemic stroke type and stroke hyperacute treatment on patient outcome Professor Thompson G Robinson Professor Ronney B Panerai
Engagement of health care professionals with interventions that change practice: It's about the Heart – but also requires a little soul Professor Timothy J Coats Matheson Dr D (University of Nottingham)
Vascular Assessment using Hyper-spectral and Infra-red Imaging Professor Mark Sims Professor Timothy J Coats
Characterisation of Fentanyl-Based Bivalent Opioids Professor David G Lambert Professor David Rowbotham (Department of Health Sciences)
Intracellular signalling pathways between nociceptin (N/OFQ) and the NOP receptor in immune cells during sepsis Professor Jonathan P Thompson Professor David G Lambert/Dr Cordula Stover (Department of Infection, Immunity and Inflammation)
Penalized regression for rare variant analysis in families Professor John Thompson (Department of Health Sciences) Dr Christopher P Nelson