Professor Alison H. Goodall

Professor of Thrombosis and Haemostasis

Profile

With a degree in Biology and PhD in Biochemistry from London University, I have my career in academia, first in London and, since 1997, in Leicester. In the 1980s I generated monoclonal antibodies and developed diagnostic and therapeutic products for patients with liver disease, haemophilia and leukaemia. In the late 1980s my research interests shifted to discovering cellular and genetic factors regulating the responses of platelets, monocytes and coagulation, and their influence on risk of heart disease. In parallel, I was a founder director of a University spin-out company (Haemostatix Ltd) to develop novel products to prevent bleeding. The company was sold in 2016 following a successful clinical trial.

My current research is focussed on the regulation of thrombosis, in particular in cardiovascular disease, and how cross-talk between vascular cells promotes atherosclerotic conditions. I also collaborate with other researchers exploring the role of blood platelets in cancer and dementia.

Research

  • Haemostatic regulation in atherothrombotic diseases
  • Platelet biology
  • Functional genomics of platelets and haemostasis
  • Genetics of cardiovascular disease
  • Platelets and cancer
  • Platelet transfusion

Publications

Johnston JM, Angyal A, Bauer R, Hamby S, Suvarna SK, Baid┼żajevas1 K, Hegedus Z, Szili D, Dear TN, Turner M, The Cardiogenics Consortium*, Wilson HL, Goodall AH, Rader D, Shoulders CC, Francis SE, Kiss-Toth E. Myeloid Tribbles 1 promotes atherosclerosis by enhancing foam cell formation. Science Advances. 2019 (Oct); eaax9183.

Godschalk TC, et al (13/26 authors). Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention: Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry. JACC Cardiovascular Intervention. 2017 Dec 26;10(24):2548-2556.

Collier ME, Ettelaie C, Goult BT, Maraveyas A, Goodall AH. Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles. Thrombosis & Haemostasis 2017 Nov;117(11):2034-44. doi: 10.1160/TH17-01-0009.

Ambrose AR., Alsahli MA, Kurmani SA, Goodall AH. Comparison of the release of microRNAs and extracellular vesicles from patients in response to different agonists. Platelets. 2017 Jul 20:1-9. doi: 10.1080/09537104.2017.1332366

Wozniak MJ, Sullo N, Qureshi S, Dott W, Cardigan R, Wiltshire M, Morris T, Nath M, Bittar N, Bhudia SK, Kumar T, Goodall AH, Murphy GJ. Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery. British Journal of Anaesthesia. 2017 May 1;118(5):689-698. doi: 10.1093/bja/aex083

Ilkan Z, Wright JR, Goodall AH, Gibbins JM, Jones CI, Mahaut-Smith MP. Evidence for Shear-mediated Ca2+ Entry through Mechanosensitive Cation Channels in Human Platelets and a Megakaryocytic Cell Line. Journal of Biological Chemistry. 2017(Jun 2); 292(22)9204-9217. doi: 10.1074/jbc.M116.766196.

Collier ME, Akinmolayan A, Goodall AH. Comparison of tissue factor expression and activity in foetal and adult endothelial cells. Blood Coagulation & Fibrinolysis. 2017 Sept; 28(6): 452-459. doi: 10.1097/MBC.0000000000000621.

Wright JR, Amisten S, Goodall AH, Mahaut-Smith MP. Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines. Thrombosis & Haemostasis. 2016 Aug 1;116(2):272-84. doi: 10.1160/TH15-11-0891.Riegger J, Byrne RA, Joner M, Chandraratne S, Gershlick AH, Ten Berg JM, Adriaenssens T, Guagliumi G, Godschalk TC, Neumann FJ, Trenk D, Feldman LJ, Steg PG, Desmet W, Alfonso F, Goodall AH, Wojdyla R, Dudek D, Philippi V, Opinaldo S, Titova A, Malik N, Cotton J, Jhagroe DA, Heestermans AA, Sinnaeve P, Vermeersch P, Valina C, Schulz C, Kastrati A, Massberg S; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort PRESTIGE Investigators. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium. European Heart Journal. 2016 May 14;37(19):1538-49. doi: 10.1093/eurheartj/ehv419.

CARDIoGRAMplusC4D Consortium. 2015. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nature Genetics. 47(10): 1121-30. doi: 10.1038/ng.3396

Good RI, McGarrity A, James TE, Miller H, McConnachie A, Goodall AH, Oldroyd KG. Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response. Thrombosis Research. 2015;135(6):1140-6

Qualifications

BSc (Biology), 1971, University of London

PhD (Biochemistry), 1979, University of London

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