With a degree in Biology and PhD in Biochemistry from London University, I have my career in academia, first in London and, since 1997, in Leicester. In the 1980s I generated monoclonal antibodies and developed diagnostic and therapeutic products for patients with liver disease, haemophilia and leukaemia. In the late 1980s my research interests shifted to discovering cellular and genetic factors regulating the responses of platelets, monocytes and coagulation, and their influence on risk of heart disease. In parallel, I was a founder director of a University spin-out company (Haemostatix Ltd) to develop novel products to prevent bleeding. The company was sold in 2016 following a successful clinical trial.
My current research is focussed on the regulation of thrombosis, in particular in cardiovascular disease, and how cross-talk between vascular cells promotes atherosclerotic conditions. I also collaborate with other researchers exploring the role of blood platelets in cancer and dementia.
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