Research Strand Macromolecular Complexes

Understanding the structure and mechanism of macromolecular complexes

vignette for macromolecular complexes

Structure determination of protein and protein nucleic acid complexes. These include complexes that regulate post-translational modifications of chromatin (Schwabe, Panne and Schalch); complexes that determine the selection of alternative pre-mRNA splicing (Dominguez and Eperon); complexes that replicate the lagging strand of DNA (De Biasio); drug targets in complex with therapeutic antibodies (Carr); complexes that assemble to bring about apoptosis (Schwabe and Fox); complexes involved in respiratory disease (Gooptu and O'Hare); heme peroxidase enzyme complexes (Moody); complexes involved in glycoprotein folding and degradation (Roversi); complexes involved in complement activation (Wallis) and membrane ion channels (Vuister and Schmid).