Research Strand Macromolecular Complexes

Understanding the structure and mechanism of macromolecular complexes

Structure determination of protein and protein nucleic acid complexes. These include complexes that regulate post-translational modifications of chromatin (Schwabe, Panne and Schalch); complexes that determine the selection of alternative pre-mRNA splicing (Dominguez and Eperon); complexes that replicate the lagging strand of DNA (De Biasio); drug targets in complex with therapeutic antibodies (Carr); complexes that assemble to bring about apoptosis (Schwabe and Fox); complexes involved in respiratory disease (Gooptu and O'Hare); heme peroxidase enzyme complexes (Moody); complexes involved in glycoprotein folding and degradation (Roversi); complexes involved in complement activation (Wallis) and membrane ion channels (Vuister and Schmid).