Meet our team

CBS facilities combine their extensive range of skills and expertise to ensure appropriate solutions to researcher’s key scientific questions.

Core Biological Services Manager

Ila Patel

ip14@le.ac.uk
+44 (0)116 252 5277


Advanced Imaging Facility

Expertise

  • Bright field and DIC
  • Large area imaging /slide scanning 
  • 2D/3D/4D imaging
  • Fluorescence 
  • Spectral imaging 
  • Bioluminescence imaging
  • F-techniques (FRAP, FLIP, FRET and FCS)
  • Correlative Light Electron Microscopy (CLEM)
  • High content screening
  • Image processing and analysis
  • TIRF

Equipment

  • FujifilmLAS4000
  • Leica TCS SP5 confocal laser scanning microscope
  • Nikon C1Si confocal laser scanning microscope
  • Olympus FV1000 confocal laser scanning microscope
  • VisiTech Infinity3 confocal laser microscope
  • Zeiss multiphoton laser scanning microscope
  • Nikon TE300 wide field microscope
  • Nikon Ti-E inverted Microscope 1
  • Nikon Ti-E inverted microscope 2
  • Olympus BX61 fluorescence and spectral microscope
  • Olympus CellR/ScanR live cell imaging and screening station
  • Bioluminescence Imaging System LV200
  • Typhoon Trio Plus, Imager and Scanner

Contact

Kees Straatman
krs5@le.ac.uk
+44 (0)116 229 7085 
+44 (0)116 252 2263


Bioinformatics Analysis Support Hub (BASH)

Expertise

  • Bioinformatics assistance 
  • Data analysis
  • Workshops and courses

Equipment

  • Access to ALICE - University of Leicester high performance computing cluster 
  • NGS user database

Contact

Jin-Li Luo
jl19@le.ac.uk
+44 (0)116 252 3350


Containment Level 3 Facility

Expertise

  • Hazard group 3 microorganisms
  • Routine bacteriology, molecular biology, tissue culture and small rodent models of infection
  • Assistance for HSE and Home Office documentation, experimental procedure design and risk assessment, animal studies

Equipment

  • 4 laboratories
  • ACDP Cat III
  • CO2 incubators

Contact

C3Facility@le.ac.uk


Electron Microscopy Facility

Expertise

  • TEM Imaging
  • SEM Imaging
  • TEM Prep – Resin Embedding, Immunogold labelling, Ultramicrotomy, Tomography
  • TEM Prep - Negative staining, Glow discharge/plasma cleaning
  • Correlative Light Electron Microscopy (CLEM)
  • SEM Prep - Critical point drying, sputter coating, Volume electron microscopy (SBFSEM) - sample preparation and consultation
  • Human, animal and plant tissues
  • Cell cultures and cell fractions
  • Micro-organisms, bacteria, biofilms and viruses
  • Membrane vesicles, exosomes and microparticles
  • Proteins and macromolecules
  • Single particle analysis
  • Nanoparticles and drug delivery mechanisms 

Equipment

  • JEOl JEM-1400 TEM
  • Hitachi S3000H SEM
  • Quorum Q150 TES
  • Balzers Critical Point Dryer
  • Leica Ultracut UC7
  • Reichert Ultracut E

Contact

Natalie Allcock
nsa2@le.ac.uk
+44 (0)116 252 3370


Flow Cytometry Facility

Expertise

  • Assay Support, Panel Design and Data Analysis
  • Multi colour assay
  • Assay transfer, development and validation.
  • Flowjo Software

Equipment

  • BD Facscanto II
  • FACSAria Fusion
  • FACSanto II
  • Cytoflex
  • Accuri C6 plus

Contact

Reshma Vaghela 
FlowCytometry@leicester.ac.uk
+44 (0)116 229 7502


NUCLEUS Genomics

Expertise

  • Single cell Transcriptomics
  • qPCR
  • Liquid Handling
  • Fluorospectrometry
  • Genome sequencing
  • Microarray

Equipment

  • ABI 7900HT PCR
  • Lightcycler 480 Real Time PCR
  • Beckman Coulter UK- Biomek FX System
  • NanoDrop 3300 Fluorospectrometer
  • Roche GS FLX genome sequencer
  • Illumina Bead Station 500
  • Illumina iScan array scanner
  • Miseq Desktop Sequencer

Contact

Nic Sylvius
Research Associate
ns249@le.ac.uk
+44 (0)116 252 3365

Reshma Vaghela
Experimental Officer
rjb40@le.ac.uk
+44 (0)116 252 3365


Histology Facility

Expertise

  • Collection and preparation of human and animal tissue
  • Cutting of frozen tissue
  • Cutting and staining to include Haematoxylin & Eosin, range of special stains (Perl`s, PAS, etc.)
  • Fixation and processing
  • Immunohistochemistry

Equipment

  • Leica CM1950
  • Leica EG1160
  • Afos VST 1 RH Ventilated Specimen Table
  • Leica ST4040 Linear H&E Stainer
  • Leica RM2235 rotary microtome
  • Microtome 2125RT
  • Leica ASP300 tissue processor

Contact

Angie Gillies
akg8@le.ac.uk
+44 (0)116 252 3235


Protex

Expertise

  • Vector Design, modification
  • High through-put cloning including mutagenesis
  • Protein expression and purification
  • SCRISPR-Cas9 genome editing

Contact

Ila Patel
ip14@le.ac.uk
+44 (0)116 2525277 


X-Ray Irradiation facility

Expertise

  • Safe irradiation of in vitro and in vivo biological samples within a laboratory environment.
  • Safer, simpler and less costly alternative to radioisotope irradiators for radiation exposure studies.

Equipment

  • RS320 X–Ray Research System

Contact 

Natalie Allcock
X-rayIrradiator@leicester.ac.uk