The management team has the primary responsibility for the delivery and project monitoring of the LD3 project portfolio, for the overall financial management of the CiC Award and management of resources within the LD3 Research Team.
Prof Don J.L. Jones - Co-director
Professor Donald Jones has been developing novel mass spectrometric technologies for incorporation into biomarker workflows to facilitate the rapid translation of biomarkers into the clinical setting. Using MS based Omics (proteomics and metabolomics) in combination with informatics and statistics, candidates are identified and then verified using targeted high throughput LC-MS methods. His particular interest is to enable high-throughput testing of discovery candidates in large patient cohorts. He is part of the precision medicine cross cutting theme of the NIHR-Biomedical Research Centre.
Prof Jacqui Shaw - Co-director
Professor Jacqui Shaw undertook a PhD in Molecular Genetics at Imperial College. After her completing her first post-doctoral post she came to Leicester in 1993 to a Lectureship in Molecular Pathology. She was appointed as Professor of Translational Cancer Genetics in 2013. Professor Shaw’s research is focused on circulating nucleic acids for early detection and monitoring of breast and lung cancers. In collaboration with Prof RC Coombes at Imperial College, she leads an integrated programme of clinical and translational research between the two universities funded by a Programme award from Cancer Research UK. She also works with Professor Charlie Swanton as part of the TRACERx major national trial analysing genetic changes in the tumours of non-small cell lung cancer patients from diagnosis and through their treatment. Professor Shaw also leads the cfDNA advisory group for the 100,000 Genomes project led by Genomics England and sits on a number of advisory boards and editorial boards of international scientific journals.LD3 Management Team
Dr Ruth Barber - Deputy Director
Ruth was one of the founder member of LD3 and has been working with the team since 2011, initially as a team member primarily focusing on the in cellulo and in vivo validation and testing of novel compounds. In 2017 Ruth became the Deputy Director of LD3, she now also manages other tranlastional funding schemes (including the MRC Proximity to Discovery Scheme) and both the Leicester Precision Medicine Institute and the Leicestershire Academic Health Partners. These roles facilitate the delivery of innovative translational research into the clinical setting to rapidly realise “real world benefit” for patients.
Dr Carl Edwards - Commercial Manager
Carl Joined LPMI as Commercial Manager in January 2018 and is responsible for engaging with commercial partners and facilitating industry led research collaborations in precision medicine. He is also providing IP and commercialisation advice to LPMI members, assisting in building a broad base of collaborations for LMPI. Carl is the UK lead for the CODEX4SME European programme to assist SMEs in developing companion diagnostics, providing networking events and access to clinical experts as part of the package of support. Carl is an experienced commercial development manager working with pharmaceutical, medical devices and venture capital companies. Carl was also Director of NHS Innovations East Midlands, responsible for IP exploitation from all NHS Trusts and was an NHS Ethics Committee Chair for 15 years.
Dr Christine Alberti-Segui - Research Manager
Christine joined LD3 in September 2018 and provides strong expertise in the development of molecular diagnostic tests, from feasibility to product validation, regulatory submission and product launch. She has past experience in microbial genetics, with a focus on host-pathogen interaction. As the new LD3 manager, Christine is responsible for the management of the team and the management of the LD3 project portfolio.
LD3 Research Team
LD3 has dedicated staff with managerial and scientific expertise, who oversee projects and conduct laboratory work in state-of-the art labs.
Dr Karen Bowman - Research Associate
Karen joined LD3 in March 2015 and is expert in cell-based assay compound screening, DNA damage and repair and in vitro, cellular and ex vivo assay development. Karen was part of the pre-clinical discovery team at the University of Newcastle upon Tyne to discover and develop the anti-cancer agent Rucaparib (brand name Rubraca® commercialised by Clovis Oncology) a first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). Karen project manages LD3 supported projects over multiple therapeutic areas such as cardiovascular disease, diabetes, oncology, and lung disease.
Dr Li-Ying Lin - Research Associate
Li-Ying joined LD3 in 2014 and have been involved in several Oncology projects. Her work is focused on providing high level technical expertise and knowledge for structure-based drug design within LD3. Li-Ying has participated in early drug discovery projects collaborating with drug discovery companies, such as GSK, LifeArc, AstraZeneca and Domainex, by offering the information of complex atomic structures of drug-like compounds and proteins which are involved in development of cancer and disease.
Dr Sian Evans - Research Associate
Sian joined the LD3 team in 2015 with the aim to drive a Discovery Fast Track Challenge programme in collaboration with GlaxoSmithKline (GSK), which has since developed successfully into a Discovery Partnerships with Academia (DPAc) award. Sian is primarily responsible for the cell based assays and compound management carried out within the DPAc here at Leicester.
Dr Susann Lehmann - Research Associate
Susann joined LD3 in January 2017 and provides extensive expertise in molecular biology and in in-vitro and cellular assay development. Since starting with LD3, Susann has worked on multiple translational projects in various research backgrounds. These include developing a mitochondrial reporter assay for compound testing in Parkinson’s disease cell culture models, to validating a cancer diagnostics test using tNGS to validating binding of murine ligands to an engineered ligand trap protein for future testing in pre-clinical models of vascular inflammation. Susann is also currently supporting the Leicester Molecular Diagnostics lab in implementing ISO15189:2012 accreditation for their cancer diagnostic testing workflows.
Carolyn Jones - Research Assistant
Carolyn joined LD3 in May 2018, and is currently supporting an oncology project to validate a cancer diagnostics test using tNGS. Carolyn has extensive industry background with AstraZeneca,and a variety of lab experience involving molecular biology and genomics techniques.
Mrs Jennifer Schofield - Senior Research Technician
Jenny joined LD3 in April 2018, and is currently supporting an oncology project: Discovery Partnerships with Academia (DPAc) in collaboration with GlaxoSmithKline (GSK) . Jenny has a variety of technical lab experience, having worked in various departments at University of Leicester since 1994. More detail on Sharepoint