Publications

2024

Functionalizing DNA Origami by Triplex-Directed Site-Specific Photo-Cross-Linking. 
Shantam Kalra, Amber Donnelly, Nishtha Singh, Daniel Matthews, Rafael Del Villar-Guerra, Victoria Bemmer, Cyril Dominguez, Natalie Allcock, Dmitry Cherny, Andrey Revyakin, and David A. Rusling. Journal of the American Chemical Society2024, 146, (19), 13617-13628. DOI: 10.1021/jacs.4c03413 J. Am. Chem. Soc. 2024, 146, 19, 13617–13628

Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids.
Gerli, M.F.M., Calà, G., Beesley, M.A. et al. Nat Med30, 875–887 (2024). https://doi.org/10.1038/s41591-024-02807-z

2023

BRAF^V600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism. 
Rzasa P, Whelan S, Farahmand P, Cai H, Guterman I, Palacios-Gallego R, Undru SS, Sandford L, Green C, Andreadi C, Mintseva M, Parrott E, Jin H, Hey F, Giblett S, Sylvius NB, Allcock NS, Straatman-Iwanowska A, Feuda R, Tufarelli C, Brown K, Pritchard C, Rufini A.  Commun Biol. 2023 Sep 21;6(1):962. doi: 10.1038/s42003-023-05331-x. PMID: 37735514; PMCID: PMC10514332.

Smart nano-actuators for electrochemical sensing of Metformin in human plasma. 
Isma Haq, Alvaro Garcia Cruz, Sabrina Di Masi, Todd Cowen, Natalie S. Allcock, Cosimino Malitesta, Adnan Mujahid, Tajamal Hussain, Elena Piletska, Sergey A. Piletsky, (2023). Sensors and Actuators B: Chemical 376.

Bypassing mitochondrial defects rescues Huntington's phenotypes in Drosophila. 
Campesan S, Del Popolo I, Marcou K, Straatman-Iwanowska A, Repici M, Boytcheva KV, Cotton VE, Allcock N, Rosato E, Kyriacou CP, Giorgini F.  Neurobiol Dis. 2023 Sep;185:106236. doi: 10.1016/j.nbd.2023.106236. Epub 2023 Jul 24. PMID: 37495179.

Amlexanox-loaded nanoliposomes showing enhanced anti-inflammatory activity in cultured macrophages: A potential formulation for treatment of oral aphthous stomatitis. 
Afaf Abouzid, Abdelrhman Y. Moustafa, Natalie Allcock, Mohammad Najlah, Abdelbary Elhissi, Chi Wi Stanley, Waqar Ahmed, Peter Seville, StJohn Crean, Robert T. Forbes, Mohamed A. Elsawy, Journal of Drug Delivery Science and Technology,Volume 79,2023,104052,ISSN 1773-2247, https://doi.org/10.1016/j.jddst.2022.104052.

2022

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane. 
Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F.Biomedicines. 2022 Sep 15;10(9):2294. doi: 10.3390/biomedicines10092294. PMID: 36140394; PMCID: PMC9496550.

Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. 
Margaritis M, Saini F, Baranowska-Clarke AA, Parsons S, Vink A, Budgeon C, Allcock N, Wagner BE, Samani NJ, von der Thüsen J, Robertus JL, Sheppard MN, Adlam D. Cardiovasc Res. 2022 Jun 22;118(7):1835-1848. doi: 10.1093/cvr/cvab183. Erratum in: Cardiovasc Res. 2023 May 2;119(3):880. doi: 10.1093/cvr/cvac070. PMID: 34048532; PMCID: PMC9215198.

Multimodal Structural Analysis of the Human Aorta: From Valve to Bifurcation. 
Liyanage L, Musto L, Budgeon C, Rutty G, Biggs M, Saratzis A, Vorp DA, Vavourakis V, Bown M, Tsamis A. Eur J Vasc Endovasc Surg. 2022 May;63(5):721-730. doi: 10.1016/j.ejvs.2022.02.005. Epub 2022 Feb 11. PMID: 35346566.

Generation of Distinct Differentially Culturable Forms of Burkholderia following Starvation at Low Temperature. 
Auty JM, Jenkins CH, Hincks J, Straatman-Iwanowska AA, Allcock N, Turapov O, Galyov EE, Harding SV, Mukamolova GV. Microbiol Spectr. 2022 Feb 23;10(1):e0211021. doi: 10.1128/spectrum.02110-21. Epub 2022 Jan 5. PMID: 34985335; PMCID: PMC8729786.

2021

Analysis of Selection Methods to Develop Novel Phage Therapy Cocktails Against Antimicrobial Resistant Clinical Isolates of Bacteria.
Haines MEK, Hodges FE, Nale JY, Mahony J, van Sinderen D, Kaczorowska J, Alrashid B, Akter M, Brown N, Sauvageau D, Sicheritz-Pontén T, Thanki AM, Millard AD, Galyov EE, Clokie MRJ. Front Microbiol. 2021 Mar 29;12:613529. doi: 10.3389/fmicb.2021.613529. eCollection 2021.PMID: 33868187

Determination of sitagliptin in human plasma using a smart electrochemical sensor based on electroactive molecularly imprinted nanoparticles. 
Haq I, Alanazi K, Czulak J, Di Masi S, Piletska E, Mujahid A, Hussain T, Piletsky SA, Garcia-Cruz A. Nanoscale Adv. 2021 May 28;3(14):4276-4285. doi: 10.1039/d1na00194a. PMID: 36132843; PMCID: PMC9419752.

2020

Genome Sequence and Characterization of Coliphage Vb Eco Slur29.
Besler, Ibrahim, Pavelas Sazinas, Christian Harrison, Lucy Gannon, Tamsin Redgwell, Slawomir Michniewski, Steven P. Hooton, Jon L. Hobman, and Andrew Millard. Phage 1, no. 1 (2020): 38-44.

Focal Epilepsy Modulates Vesicular Positioning at Cortical Synapses.
Vannini, Eleonora, Laura Restani, Marialaura Dilillo, Liam McDonnell, Matteo Caleo, and Vincenzo Marra. Preprint - BioRxiv(2020). 

2019

Dedicated Setup for the Photoconversion of Fluorescent Dyes for Functional Electron Microscopy.
Dobson, Katharine L., Carmel L. Howe, Yuri Nishimura, and Vincenzo Marra. Frontiers in Cellular Neuroscience 13 (2019). 

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability.
Heaselgrave, W., A. Hamad, S. Coles, and S. Hau. Transl Vis Sci Technol 8, no. 5 (Sep 2019): 17. 

vB_PaeM_MIJ3, a Novel Jumbo Phage Infecting Pseudomonas aeruginosa, Possesses Unusual Genomic Features.
Imam M, Alrashid B, Patel F, Dowah ASA, Brown N, Millard A, Clokie MRJ, Galyov EE.Front Microbiol. 2019 Nov 28;10:2772. doi: 10.3389/fmicb.2019.02772. eCollection 2019. PMID: 31849908

Mycobacterial Phosphatase Pstp Regulates Global Serine Threonine Phosphorylation and Cell Division. 
Iswahyudi, G. V. Mukamolova, A. A. Straatman-Iwanowska, N. Allcock, P. Ajuh, O. Turapov, and H. M. O'Hare. Sci Rep 9, no. 1 (Jun 6 2019): 8337. 

The Lytic Transglycosylase, Ltgg, Controls Cell Morphology and Virulence in Burkholderia Pseudomallei.
Jenkins, C. H., R. Wallis, N. Allcock, K. B. Barnes, M. I. Richards, J. M. Auty, E. E. Galyov, S. V. Harding, and G. V. Mukamolova. Sci Rep 9, no. 1 (Jul 30 2019): 11060.

Riding the Wave of Genomics to Investigate Aquatic Coliphage Diversity and Activity.
Michniewski, S., T. Redgwell, A. Grigonyte, B. Rihtman, M. Aguilo-Ferretjans, J. Christie-Oleza, E. Jameson, D. J. Scanlan, and A. D. Millard. Environ Microbiol 21, no. 6 (Jun 2019): 2112-28.

Functional Assessment of Microbial Superoxide Dismutase Isozymes Suggests a Differential Role for Each Isozyme.
Najmuldeen, H., R. Alghamdi, F. Alghofaili, and H. Yesilkaya. Free Radic Biol Med 134 (Apr 2019): 215-28.

Optimisation of the Preservation Conditions for Molecularly Imprinted Polymer Nanoparticles Specific for Trypsin.
Safaryan, Abeer H. M., Adam M. Smith, Thomas S. Bedwell, Elena V. Piletska, Francesco Canfarotta, and Sergey A. Piletsky. Nanoscale Advances (2019).

Genomic Characterization of Jumbo Salmonella Phages That Effectively Target United Kingdom Pig-Associated Salmonella Serotypes.
Thanki, Anisha M., Nathan Brown, Andrew D. Millard, and Martha R. J. Clokie. Frontiers in Microbiology 10 (2019). 

2018

Ex Vivo Modelling of the Formation of Inflammatory Platelet-Leucocyte Aggregates and Their Adhesion on Endothelial Cells, an Early Event in Sepsis.
Alharbi, Azzah, Jonathan P Thompson, Nicholas P Brindle, and Cordula Stover. Clinical and Experimental Medicine (2018).

Ferritag Is a New Genetically-Encoded Inducible Tag for Correlative Light-Electron Microscopy.
Clarke, N. I. and S. J. Royle. Nat Commun 9, no. 1 (Jul 4 2018): 2604. 

Intracellular Replication of Streptococcus Pneumoniae inside Splenic Macrophages Serves as a Reservoir for Septicaemia.
Ercoli, G., V. E. Fernandes, W. Y. Chung, J. J. Wanford, S. Thomson, C. D. Bayliss, K. Straatman, P. R. Crocker, A. Dennison, L. Martinez-Pomares, P. W. Andrew, E. R. Moxon, and M. R. Oggioni. Nat Microbiol 3, no. 5 (May 2018): 600-10. 

Molecularly Imprinted Polymer Nanoparticle-Based Assay (Mina): Application for Fumonisin B1 Determination.
Munawar, H., K. Smolinska-Kempisty, A. G. Cruz, F. Canfarotta, E. Piletska, K. Karim, and S. A. Piletsky. Analyst 143, no. 14 (Jul 9 2018): 3481-88.

Two Faces of Cwlm, an Essential Pknb Substrate, in Mycobacterium Tuberculosis.
Turapov, O., F. Forti, B. Kadhim, D. Ghisotti, J. Sassine, A. Straatman-Iwanowska, A. R. Bottrill, P. J. Moynihan, R. Wallis, P. Barthe, M. Cohen-Gonsaud, P. Ajuh, W. Vollmer, and G. V. Mukamolova. Cell Rep 25, no. 1 (Oct 2 2018): 57-67 e5. 

Characterisation of Crispr Mutants Targeting Genes Modulating Pectin Degradation in Ripening Tomato.
Wang, D., N. Samsulrizal, C. Yan, N. S. Allcock, J. Craigon, B. Blanco-Ulate, I. Ortega-Salazar, S. E. Marcus, H. M. Bagheri, L. Perez-Fons, P. D. Fraser, T. Foster, R. G. Fray, J. P. Knox, and G. B. Seymour. Plant Physiol (Nov 20 2018).

2017

Biology and Genomics of an Historic Therapeutic Escherichia coli Bacteriophage Collection.
Baig A, Colom J, Barrow P, Schouler C, Moodley A, Lavigne R, Atterbury R. Front Microbiol. 2017 Aug 30;8:1652. doi: 10.3389/fmicb.2017.01652. eCollection 2017. PMID: 28912765

Suppressors of the Chloroplast Protein Import Mutant tic40 Reveal a Genetic Link between Protein Import and Thylakoid Biogenesis.
Bédard J, Trösch R, Wu F, Ling Q, Flores-Pérez Ú, Töpel M, Nawaz F, Jarvis P.Plant Cell. 2017 Jul;29(7):1726-1747. doi: 10.1105/tpc.16.00962. Epub 2017 Jul 6.PMID: 28684427

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation.
Hussey SJK, Purves J,Allcock N, Fernandes VE, Monks PS, Ketley JM, Andrew PW, Morrissey JA. Environ Microbiol. 2017 May;19(5):1868-1880. doi: 10.1111/1462-2920.13686. Epub 2017 Feb 28.PMID: 28195384

Microencapsulation of Clostridium Difficile Specific Bacteriophages Using Microfluidic Glass Capillary Devices for Colon Delivery Using Ph Triggered Release. Vinner, G. K., G. T. Vladisavljevic, M. R. J. Clokie, and D. J. Malik. PLoS One 12, no. 10 (2017): e0186239.

New Tools for "Hot-Wiring" Clathrin-Mediated Endocytosis with Temporal and Spatial Precision. Wood, LA, G Larocque, N Clarke, S Sarkar, and SJ Royle. J Cell Biol. 2017 Dec 4;216(12):4351-4365. doi: 10.1083/jcb.201702188. Epub 2017 Sep 27. PMID: 28954824; PMCID: PMC5716275.