BRC Projects 2023
Cardiovascular
- Dr David Adlam: Investigating the molecular and cellular basis for SCAD (25kb docx.)
- Dr Emer Brady: Tracking Type 2 Diabetes Remission for Heart Health (29kb docx.)
- Professor G Andre Ng: Sudden Cardiac Death Risk Stratification using ECG and Artificial Intelligence (24kb docx.)
- Professor Gavin Murphy: Epigenetic regulation of myocardial cell signaling in multiple long-term conditions and frailty (503kb docx.)
Respiratory and Infection
- Dr Spyridon Megremis: Development of an in vitro culture system to study the lung microcosm in airway diseases (24kb docx.)
- Dr Katy Roach: TRPM7; a potential therapeutic target in idiopathic pulmonary fibrosis (26kb docx.)
- Dr Lorna Latimer: Extra-pulmonary characteristics of people with COPD and lung hyperinflation and the effects of lung volume reduction (24kb docx.)
- Dr David Lo: Post-infectious bronchiolitis obliterans (PIBO) in Children – epidemiology, differences in care, and risk factors for poor outcomes, a mixed methods study (25kb docx.)
- Dr Richard Allen: The role of rare genetic variants in fibrosis (23kb docx.)
Lifestyle
- Dr Dimitrios Papamargaritis: The weight loss independent effects of new obesity pharmacotherapies on glycaemia, cardiometabolic parameters and weight regulation mechanisms in people with obesity and type 2 diabetes (25kb docx.)
- Professor Louise Goff: Investigating ethnic differences in the response to intensive weight loss in those living with obesity and cardiometabolic disease (27kb docx.)
- Dr Emma Watson: Skeletal muscle pathology in obesity related conditions (25kb docx.)
- Dr Joe Henson: Using physical activity and physical function metrics to develop a ‘movement age’ and personalized intervention in those with multiple long-term conditions (MLTCs) (25kb docx.)
Personalised Cancer Prevention and Treatment
- Professor Karen Brown: COLO-PREVENT ex vivo: the application of patient derived tissue models for investigating mechanisms of action of aspirin, metformin and resveratrol in the prevention of colorectal cancer (33kb docx.)
- Dr Ricky Joshi: Use of Oxford Nanopore Technology liquid biopsy workflows for early cancer detection, tissue-of-origin prediction and personalising cancer treatment (24kb docx.)
- Professor Dean Fennell: PRC2-DNMT1 axis as a synthetic lethal target in BAP1 mutant mesothelioma (24kb docx.)
- Dr Gareth Miles: ctDNA meets Patient Derived Explants (PDEs): developing ctDNA predictive biomarkers for novel anti-cancer agents derived from PDE meta-data (31kb docx.)
Environment
- Dr Leah Cuthbertson: The relationship between environmental fungi and clinical fungal infections in patients with chronic respiratory disease (25kb docx.)
- Professor Bibek Gooptu: Characterising potential exposure triggers in people of South Asian ethnicity diagnosed with Hypersensitivity Pneumonitis (HP) (31kb docx.)
Data Innovation for Multiple Long Term Conditions and Ethnic Health
- Dr Safoora Gharibzadeh: Comparing Causal Inference and Survival analysis Approaches to Estimate the Effect of Type 2 Diabetes on incidence of hip fracture and its association with multi-morbidity and mortality (30kb docx.)
- Dr Sarah Booth: Enabling fair comparisons of the impact of long-term health conditions on life expectancy in multimorbid populations: development and enhancement of statistical methodology (25kb docx.)
Cross theme projects
- Professor Julie Morrissey: How does exposure to air pollutants impacts respiratory bacteria and subsequent disease? (25kb docx.)
- Dr Robert Free: Integrating cancer genomics data to support clinical decision making in the era of precision medicine (27kb docx.)
- Professor Laura Gray: Optimising the design and analysis of trials in multiple long term conditions (24kb docx.)
- Dr Esther Moss: Looking into the future: alleviating psychological impact of circulating tumour DNA monitoring following cancer treatment (24kb docx.)
- Dr Hannah Young: Supporting people with long term conditions from underserved groups to improve their 24-hour physical behaviours: a mixed-methods study (587kb docx.)
- Dr Luke Baker: Understanding how resolution physiology influences skeletal muscle endotype in those with multiple long-term conditions (MLTCs) ((24kb docx)
- Associate Professor Erol Gaillard: Improving access to asthma care for children and young people and caregivers from underserved communities (45kb docx.)
- Dr Ranjit Arnold: Establishing normative ranges for cardiopulmonary function in transgender people: a pilot, feasibility study (25kb docx.)
- Dr Charlotte Edwardson: Collecting and utilising accelerometer data from patients in early phase cancer trials to assess physical activity and fatigue (26kb docx.)
- Dr Enya Daynes: Exploring breathlessness perceptions and breathlessness response to exercise among different cultures and ethnic minority groups, and the impact on treatment access and uptake (25kb docx.)
- Dr Rachel Evans: Identification, trajectory, and risk factors for physical inactivity after a hospitalisation from COVID-19: Association with Long Covid and newly acquired conditions (24kb docx.)