X-ray crystallography

staff member using an xray crystallography machineX-ray crystallography is a technique used to establish molecular structure by interpretation of diffraction data when a single crystal is placed in an X-ray beam. Provided the sample can be obtained as a single crystal of suitable size, the results reveal the 3D molecular structure and the relative orientation of groups, together with the intra- and intermolecular bond distances and angles.

The service is also available on a contractual basis, please contact Kuldip Singh for more details.

Bruker APEX Smart 2000 Diffractometer

  • Location: Second floor George Porter Building, University Road end, near to lift, Room 2.15
  • Primary use: Chemistry research

About

The department has a Bruker APEX 2000 diffractometer, which has a 4k CCD detector, allowing rapid data acquisition for most samples. The sensitive detector also makes it possible to collect data from samples of smaller crystals (<0.1mm). Samples are routinely cooled to 150K using an Oxford Cyrostream cooler. The diffractometer usually operates with Mo- Ka radiation that is ideal for small molecule crystallography. Typical molecular determinations have between 10 and 200 unique non-hydrogen atoms.