Nuclear magnetic resonance spectroscopy

Nuclear magnetic resonance (NMR) spectroscopy in the Department of Chemistry is provided by three state-of-the-art, high-resolution solution state instruments. This service is available to both undergraduates and postgraduates for applications such as confirmation of target synthesis, structure elucidation and mechanistic analysis.

The service is also available on a contractual basis. Contact Dr Rebecca Hawker for more details: chemnmr@le.ac.uk.

Bruker Avance NEO 500 MHz with Insight Xpress

Location: George Porter Building, Lower Ground Floor, -1.20
Primary use: Postgraduate Research
Access: Restricted Access
Probes: BBO Prodigy Cryoprobe (¹H / ¹⁹F / ¹⁵N—³¹P) + BBFO SmartProbe (¹H / ¹⁹F / ¹⁵N—³¹P)
Variable temperature: High and low temperature available
Accessories: Insight XPress Stopped-Flow Accessory

About

The AVNEO500 is our newest NMR spectrometer, installed January 2023 as part of our EPSRC Strategic Equipment Grant (EP/W02151X/1). The spectrometer is used for research with access for trained users. The spectrometer has a 60 position sample changer and two probes: a 5 mm Prodigy BBO cryoprobe and BBFO SmartProbe. It is capable of running a wide range of 1D and 2D spectra on a multitude of NMR nuclei, as well as DOSY spectra. The instrument is also capable of monitoring fast reactions with the InsightXpress Stopped Flow Accessory.

Bruker Avance III 500 MHz

Location: George Porter Building, first floor, 1.03
Primary use: Undergraduate teaching
Access: Open access with sample changer
Probe: BBO 5mm – Z gradient (¹H / ³¹P—¹⁰⁹Ag)
Variable temperature: Low and high temperature available

About

The AVIII500 spectrometer is the open access NMR spectrometer for undergraduates. Postgraduate research workers may use the spectrometer when undergraduate lab classes are not running. It is equipped with a 5mm BBO probe and a 60 position sample changer which is controlled and accessed using ICONNMR software. Longer experiments (¹³C{1H}, and 2D spectra – such as COSY and HSQC) should be submitted for overnight accumulation after 7 pm on weekdays or at weekends. For NMR experiments not in the automation window, please consult the experimental officer.

Bruker Avance III HD 400 MHz

Location: George Porter Building, second floor, 2.02
Primary use: Postgraduate research
Access: Open access with sample changer
Probe: BBFO 5mm – Z gradient (¹H / ¹⁹F / ¹⁵N—³¹P)
Variable temperature: High temperature available

About

The AVIIIHD400 spectrometer is the open access NMR spectrometer for undergraduate and postgraduate research. The spectrometer has a 5mm BBFO probe and a 60 position sample changer which is controlled and accessed using ICONNMR software. It can run a wide range of 1D and 2D spectra on a multitude of NMR nuclei.