University of Leicester BHF Research Accelerator for Precision Medicine

Joanne Miksza

joanne miksza profileBiostatistician

jm830@leicester.ac.uk

Background

Joanne completed an undergraduate degree in Mathematics and Economics with the Open University before gaining an MSc in Medical Statistics at the University of Leicester. She joined the Real World Evidence Unit at Leicester Diabetes Centre as an Epidemiologist prior to her current role.

Research interests

  • The use of large electronically collected health datasets to analyse outcomes in a real world population.
  • Formulating analysis plans to investigate electronically collected health data.
  • Statistical analysis and data cleaning methods specific to these large datasets.
  • Using Hospital Episode Statistics data to perform in silico clinical trials.

Publications

Ling S, Brown K, Miksza JK, Howells L, Morrison A, Issa E, Yates T, Khunti K, Davies MJ, Zaccardi F. (2020). Association of Type 2 Diabetes With Cancer: A Meta-analysis With Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million People. Diabetes Care, Sep 2020; 43(9): 2313-2322. DOI: 10.2337/dc20_0204

Ling S, Brown K, Miksza JK, Howells LM, Morrison A, Issa E, Yates T, Khunti K, Davies MJ, Zaccardi F. (2020). Risk of cancer incidence and mortality associated with diabetes: A systematic review with trend analysis of 203 cohorts. Nutr Metab Cardiovasc Dis. 2021 Jan 4;31(1):14-22.        doi:10.1016/j.numecd.2020.09.023. Epub 2020 Sep 25.

Gray LJ, Brady EM, Albaina O, Edwardson CL, Harrington D, Khunti K, Miksza J, Raposo JF, Smith E, Vazeou A, Vergara I, Weihrauch-Blüher S, Davies MJ; PRE-STARt Collaborative. Evaluation and refinement of the PRESTARt tool for identifying 12-14 year olds at high lifetime risk of developing type 2 diabetes compared to a clinicians assessment of risk: a cross-sectional study. BMC Endocr Disord. 2019 Jul 25;19(1):79. doi: 10.1186/s12902-019-0410-3. PMID: 31345191; PMCID: PMC6659313.

Packham C, Butcher E, Williams M, Miksza J, Morriss R, Khunti K. Cardiovascular risk profiles and the uptake of the NHS Healthcheck programme in male prisoners in six UK prisons: an observational cross-sectional survey. BMJ Open. 2020 May 24;10(5):e033498. doi: 10.1136/bmjopen-2019-033498. PMID: 32448789; PMCID: PMC7253003.

Miksza JK, Zaccardi F, Kunutsor SK, Seidu S, Davies MJ, Khunti K. Statins and risk of thromboembolism: A meta-regression to disentangle the efficacy-to-effectiveness gap using observational and trial evidence. Nutr Metab Cardiovasc Dis. 2019 Oct;29(10):1023-1029. doi: 10.1016/j.numecd.2019.06.022. Epub 2019 Jul 6. PMID: 31383500.

Chetan MR, Miksza JK, Lawrence I, Anjana RM, Unnikrishnan R, Amutha A, Shanthi Rani CS, Jebarani S, Mohan V, Khunti K, Narendran P. The increased risk of microvascular complications in South Asians with type 1 diabetes is influenced by migration. Diabet Med. 2020 Dec;37(12):2136-2142. doi: 10.1111/dme.14184. Epub 2019 Nov 28. PMID: 31721280.

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