Institute for Precision Health


Take a look at publications by members of the Institute for Precision Health.

Chris Brightling

Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial. DOI:/10.1016/j.jaci.2021.03.044

PHOSP-COVID Collaborative Group. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. DOI:10.1016/S2213-2600(22)00127-8

Risankizumab in severe asthma – a phase 2a, placebo-controlled trial. DOI:10.1056/NEJMoa2030880

Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial. DOI:10.1016/S2213-2600(21)00226-5 

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. DOI:10.1016/S2213-2600(21)00383-0

Jacqui Shaw

Tracking the Evolution of Non-Small-Cell Lung Cancer. DOI:10.1056/NEJMoa1616288

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. DOI:10.1038/nature22364

Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence. DOI:10.1158/1078-0432.CCR-18-3663

Prevalence of ctDNA in early screen-detected breast cancers using highly sensitive and specific dual molecular barcoded personalised mutation assays. DOI:10.1016/j.annonc.2021.04.018

Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease. DOI:10.1200/PO.20.00522

Don Jones

Cov-MS: A Community-Based Template Assay for Mass-Spectrometry-Based Protein Detection in SARS-CoV-2 Patients. DOI:10.1021/jacsau.1c00048 

Mass spectrometric detection of KRAS protein mutations using molecular imprinting. DOI:10.1039/d1nr03180e 

Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction. DOI:10.1373/clinchem.2016.264853

Modulation of acetylcholinesterase activity using molecularly imprinted polymer nanoparticles. DOI:10.1039/d2tb00278g

Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets. DOI:10.1002/ejhf.1608

Lynne Howells

Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery. DOI:10.1038/s41416-019-0672-6

Risk of cancer incidence and mortality associated with diabetes: A systematic review with trend analysis of 203 cohorts. DOI:10.1016/j.numecd.2020.09.023

Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial. DOI:10.1093/jn/nxz029

Inequalities in cancer screening, prevention and service engagement between UK ethnic minority groups. DOI:10.12968/bjon.2022.31.10.S14

Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants. DOI:10.1038/s41374-020-00511-3

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