Publications

Publications which have made use of the Midlands Regional Cryo-EM Facility.

  • Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R, Crowther RA, Newell KL, Ghetti B, Goedert M, Scheres SHW. "Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules." Nature. 2019 Apr; 568(7752):420-423. doi: 10.1038/s41586-019-1026-5. Epub 2019 Mar 20. PubMed PMID: 30894745; PubMed Central PMCID: PMC6472968.
  • Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M. "The pore structure of Clostridium perfringens epsilon toxin." Nat Commun. 2019 Jun 14;10(1):2641. doi: 10.1038/s41467-019-10645-8. PubMed PMID: 31201325; PubMed Central PMCID: PMC6572795.
  • Míguez Amil S, Jiménez-Ortega E, Ramírez-Escudero M, Talens-Perales D, Marín-Navarro J, Polaina J, Sanz-Aparicio J, Fernandez-Leiro R. "The cryo-EM Structure of Thermotoga maritima β-Galactosidase: Quaternary Structure Guides Protein Engineering." ACS Chem Biol. 2020 Jan 17;15(1):179-188. doi: 10.1021/acschembio.9b00752. Epub 2019 Dec 24. PubMed PMID: 31874027.
  • Flydal MI, Alcorlo-Pagés M, Johannessen FG, Martínez-Caballero S, Skjærven L, Fernandez-Leiro R, Martinez A, Hermoso JA. "Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin." Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11229-11234. doi: 10.1073/pnas.1902639116. Epub 2019 May 22. PubMed PMID: 31118288; PubMed Central PMCID: PMC6561269.
  • Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR. "Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex." Cell Rep. 2020 Feb 25;30(8):2699-2711.e8. doi: 10.1016/j.celrep.2020.01.091. PubMed PMID: 32101746; PubMed Central PMCID: PMC7043024.
  • Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A. "Structure of the processive human Pol δ holoenzyme." Nat Commun. 2020 Feb 28;11(1):1109. doi:10.1038/s41467-020-14898-6. PubMed PMID: 32111820; PubMed Central PMCID: PMC7048817.
  • Turnbull RE, Fairall L, Saleh A, Kelsall E, Morris KL, Ragan TJ, Savva CG, Chandru A, Millard CJ1,2, Makarova OV, Smith CJ, Roseman AM, Fry AM, Cowley SM, Schwabe JWR. "The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure." Nat Commun. 2020 Jun 26;11(1):3252. doi: 10.1038/s41467-020-17078-8. PMID: 32591534.
  • Higashi TL, Eickhoff P, Sousa JS, Locke J, Nans A, Flynn HR, Snijders AP, Papageorgiou G, O'Reilly N, Chen ZA, O'Reilly FJ, Rappsilber J, Costa A, Uhlmann F. "A Structure-Based Mechanism for DNA Entry into the Cohesin Ring." Mol Cell. 2020 Jul 30:S1097-2765(20)30503-7. doi: 10.1016/j.molcel.2020.07.013. Online ahead of print. PMID: 32755595