Leicester Institute of Structural and Chemical Biology

Chemical Biology

chemical biology equipmentChemical biology expertise at Leicester covers a broad range of synthetic capabilities and physical measurement methodologies, including:

Synthetic capabilities:

  • Novel small molecule libraries - Generation of bespoke small molecule libraries for emerging approaches such as the development of proteolysis targeting chimeras (PROTACs) and protein-protein interaction inhibitors
  • Small and large-scale synthesis of peptides, peptoids, PNA and peptidomimetics. Solid- phase peptide synthesis using an automated microwave peptide synthesiser
  • Custom DNA oligonucleotide synthesis
  • Computer modelling for small molecule ligand design
  • Fluorescent labelling of small molecule ligands and peptides Novel design of transition metal luminescent probes for imaging in cells
  • Novel contrast agents for magnetic resonance imaging (MRI)

Physical measurement:

  • Customised spectroscopy strategies for new assay methodologies
  • Design of fluorescence and label-free based biosensors
  • Label-free imaging and sensing
  • Micro fluidic strategies: including digital droplet single cell analysis, or single molecule quantification
  • Optical manipulation of live cells
  • Biological force measurements: mechanochemical cell and single molecule biology
  • Raman and fluorescence confocal microspectroscopy
  • Computer modelling: quantum mechanical ab initio calculations and classical molecular modelling

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