Publications

Selected publications from group members are listed below.

2021

Formaldehyde regulates tetrahydrofolate stability and thymidylate synthase catalysisX. Chen, S. Y. Chothia, J. Basran, R. J. Hopkinson*, Chemical Communications, 2021, 57, 5778.

2020

Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde, R. Reinbold, T. John, P. Spingardi, A. Kawamura, C. J. Schofield, R. J. Hopkinson, Scientific Reports, 2020, 17955

2019

Formaldehyde quantification using ampicillin is not selective, R. Reinbold, T. John, P. Spingardi, A. Kawamura, C. J. Schofield*, R. J. Hopkinson*, Scientific Reports, 2019, 18289.

2018

Mechanistic and Structural Studies of KDM-Catalysed Demethylation of Histone 1 Isotype 4 at Lysine 26, L. J. Walport, R. J. Hopkinson, R. Chowdhury, Y. Zhang, J. Bonnici, R. Schiller, A. Kawamura, C. J. Schofield*, FEBS Letters, 592, 3264–3273.

Human histone demethylase KDM6B can catalyse sequential oxidations, R. J. Hopkinson*, G. W. Langley, R. Belle, L. J. Walport, K. Dunne, E. Salah, A. Kawamura, T. D. W. Claridge, C. J. Schofield*, Chemical Communications, 2018, 54, 7975-7978.

Integrative analysis of fitness and metabolic effects of plasmids in Pseudomonas aeruginosa PAO1, A. San Millan*, M. Toll-Riera*, Q. Qin, A. Betts, R. J. Hopkinson, J. S. McCullagh, R. C. MacLean, The ISME Journal, 12, 3014-3024.

NMR Analyses on N-Hydroxymethylated Nucleobases – Implications for Formaldehyde Toxicity and Nucleic Acid Demethylases, S. Shishodia, D. Zhang, A. El-Sagheer, T. Brown, T. D. W. Claridge, C. J. Schofield, R. J. Hopkinson*, Organic and Biomolecular Chemistry, 2018, 16, 4021-4032.

Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation, R. L. Hancock, M. I. Abboud, T. J. Smart, E. Flashman, A. Kawamura, C. J. Schofield*, R. J. Hopkinson*, ChemBioChem, 2018, 19, 917-921.

Deciphering Functions of Intracellular Formaldehyde - Linking Cancer and Aldehyde Metabolism, R. J. Hopkinson*, C. J. Schofield*, Biochemistry, 2018, 57(6), 904-906.