Publications
Acknowledgements
If you publish work supported by the AIF, e.g. by using one or more of our microscope systems or by support in image or data analysis, it is obligatory to include a sentence in the acknowledgement in addition to any personal acknowledgement. For example:
"We thank the Advanced Imaging Facility (RRID:SCR_020967) at the University of Leicester for support."
Please include the RRID number (Research Resource IDentifier) what is a international unique identifier allocated to the AIF.
When publishing results obtained using the Zeiss LSM980 Airyscan 2 confocal laser scanning microscope you are also required to acknowledge the BBSRC grant nr: BB/S019510/1.
2024
Li Y, Fang J, Singh K, Ortu F, Suntharalingam K (2024) An immunogenic anti-cancer stem cell bi-nuclear copper(II)-flufenamic acid complex. Dalton Trans. doi: 10.1039/d4dt00384e. PubMed.
Pashley SL, Papageorgiou S, O’Regan L, Barone G, Robinson SW, Lucken K, Straatman KR, Roig J, Fry AM (2024) The mesenchymal morphology of cells expressing the EML4-ALK V3 oncogene is dependent on phosphorylation of Eg5 by NEK7. JBC doi: 10.1016/j.jbc.2024.107144. PubMed.
Fang J, Orobator ON, Olelewe C, Passeri G, Singh K, Awuah SG, Suntharalingam K (2024) A Breast Cancer Stem Active Cobalt(III)-Cyclam Complex Containing Flufenamic Acid with Immunogenic Potential (2024) Angew Chem Int Ed Engl. 63(6):e202317940. doi: 10.1002/anie.202317940. PubMed.
Tax G, Guay KP, Pantalone L, Ceci M, Soldà T, Hitchman CJ, Hill JC, Vasiljević S, Lia A, Modenutti CP, Straatman KR, Santino A, Molinari M, Zitzmann N, Hebert DN, Roversi P, Trerotola M (2024) Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells. Traffic. 25:e12927. PubMed.
2023
Hindul NL, Abbott LR, Adan SMD, Straatman KR, Fry AM, Hirota K, Tanaka K (2023) Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells. bioRxiv 2023.09.08.556827; doi:https://doi.org/10.1101/2023.09.08.556827.Johnson A, Feng X, Singh K, Ortu F, Suntharalingam K. (2023) The Anti-Breast Cancer Stem Cell Potency of Copper(I)-Non-Steroidal Anti-Inflammatory Drug Complexes. Molecules. 28:6401. PubMed.
Campesan S, Del Popolo I, Marcou K, Straatman-Iwanowska A, Repici M, Boytcheva KV, Cotton VE, Allcock N, Rosato E, Kyriacou CP, Giorgini F (2023) Bypassing mitochondrial defects rescues Huntington's phenotypes in Drosophila. Neurobiol Dis.:106236. doi: 10.1016/j.nbd.2023.106236. PubMed.
Tax G, Guay KP, Soldà T, Hitchman CJ, JHill JC, Vasiljević S, Lia A, Modenutti CP, Straatman KR, Santino A, Molinari M, Zitzmann N, Hebert DN, Roversi P, Trerotola M (2023) Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells. bioRxiv 2023.05.30.542711; doi: https://doi.org/10.1101/2023.05.30.542711.
Osei P, Northcote-Smith J, Fang J, Singh K, Ortu F, Suntharalingam K (2023) The Bulk Breast Cancer Cell and Breast Cancer Stem Cell Activity of Bi-nuclear Copper(II)-Phenanthroline Complexes. Chemistry. 30:e202301188. PubMed.
Rauf A, Khatab H, Borg M, Twell D (2023) Genetic control of generative cell shape by DUO1 in Arabidopsis. Plant Reprod. doi: 10.1007/s00497-023-00462-x. PubMed.
Bird MF, Hebbes CP, Tamang A, Willets J, Thompson JP, Guerrini R, Calo G, Lambert DG (2023) In vitro sepsis upregulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells. Br J Pharmacol. doi: 10.1111/bph.16088. PubMed.
Passeri G, Northcote-Smith J, Suntharalingam K. (2023) Payload Release Profile and Anti-Cancer Stem Cell Properties of Compositionally Different Polymeric Nanoparticles Containing a Copper(II) Complex. Molecules. 28:2506. PubMed.
Bezdekova J, Canfarotta F, Grillo F, Yesilkaya H, Vaculovicova M, Piletsky S (2023) Molecularly imprinted nanoparticles for pathogen visualisation. Nanoscale 5: 2602-2609. PubMed.
Dave N, Albiheyri RS, Wanford JJ, Green LR, Oldfield NJ, Turner DPJ, Martinez-Pomares L, Bayliss CD (2023) Variable disruption of epithelial monolayers by Neisseria meningitidis carriage isolates of the hypervirulent MenW cc11 and MenY cc23 lineages. Microbiology (Reading). 169:001305. doi: 10.1099/mic.0.001305. PubMed.
Singh A, Busacca S, Gaba A, Sheaff M, Poile C, Nakas A, Dzialo J, Bzura A, Dawson AG, Fennell DA, Fry AM (2023) BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms. Oncogene. 42: 572-585. PubMed.
Passeri G, Vincent RA, Xiao Z, Northcote-Smith J, Suntharalingam K (2023) Encapsulation and Delivery of an Osteosarcoma Stem Cell Active Gallium(III)-Diflunisal Complex Using Polymeric Micelles. ChemMedChem. 18(4):e202200599. PubMed.
2022
Giakomidi D, Khemiri S, Mahbuba W, McVey DG, Al-Janabi F, Guerrini R, Calo G, Ye S, Lambert DG (2022) Nociceptin/Orphanin FQ receptor expression in primary human umbilical vein endothelial cells is not regulated by exposure to breast cancer cell media or angiogenic stimuli. BJA Open, 4: Article 100110. doi: 10.1016/j.bjao.2022.100110.
Khan S, Miles GJ, Demetriou C, Sidat Z, Foreman N, West K, Karmokar A, Howells L, Pritchard C, Thomas AL, Brown K (2022) Ex vivo explant model of adenoma and colorectal cancer to explore mechanisms of action and patient response to cancer prevention therapies. Mutagenesis. 37:227-237. PubMed.
Ibrahim Z, Wang T, Destaing O, Salvi N, Hoghoughi N, Chabert C, Rusu A, Gao J, Feletto L, Reynoird N, Schalch T, Zhao Y, Blackledge M, Khochbin S, Panne D (2022) Structural insights into p300 regulation and acetylation-dependent genome organisation. Nat Commun. 13:7759. doi: 10.1038/s41467-022-35375-2. PubMed.
Malki I, Liepina I, Kogelnik N, Watmuff H, Robinson S, Lightfoot A, Gonchar O, Bottrill A, Fry AM, Dominguez C (2022) Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity, and cellular functions. Nucleic Acids Res. 50:13045-13062. PubMed.
Vincent RA, Passeri G, Northcote-Smith J, Singh K, Suntharalingam K (2022) The Osteosarcoma Stem Cell Activity of a Gallium(III)-Phenanthroline Complex Appended to Salicylate. Chembiochem. 23:e202200532. PubMed.
Bird MF, Gallacher-Horley B, McDonald J, McVey DG, Al-Janabi F, Guerrini R, Calo G, Ye S, Thompson JP, Lambert DG (2022) In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells. PLoS One. 17(9):e0274080. PubMed.
Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F (2022) Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane. Biomedicines. 10:2294. doi: 10.3390/biomedicines10092294. PubMed.
Stylianou P, Rushwan S, Wang W, Miah MA, Darweesh O, Mackinnon A, Roach KM, Hitchman CJ, Gonchar O, Thorpe S, Harris C, Haigh R, Richards DF, Snetkov V, Beasley J, Cleary SJ, Barer M, Ward JPT, Rooney C, McCaughan F, Bradding P, Beale R, Knight MM, Sethi T, Gooptu B (2022) CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis. bioRxiv 2022.08.12.503154; doi: 10.1101/2022.08.12.503154.
Morris GE, Denniff MJ, Karamanavi E, Andrews SA, Kostogrys RB, Bountziouka V, Ghaderi-Najafabadi M, Shamkhi N, McConnell G, Kaiser MA, Carleton L, Schofield C, Kessler T, Rainbow RD, Samani NJ, Webb TR (2022) The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrin α9β1 and α4β1. Br J Pharmacol. doi: 10.1111/bph.15921. PubMed.
Hames RG, Jasiunaite Z, Ercoli G, Wanford JJ, Carreno D, Straatman K, Martinez-Pomares L, Yesilkaya H, Glenn S, Moxon ER, Andrew PW, Kyriacou CP, Oggioni MR (2022) Diurnal Differences in Intracellular Replication Within Splenic Macrophages Correlates With the Outcome of Pneumococcal Infection. Front Immunol 13. PubMed.
Blockley A, Ogle D, Woodrow C, Montealegre-Z F, Warren B (2022) Physiological changes throughout an insect ear due to age and noise - A longitudinal study. iScience. 25:104746. PubMed.
Lucken K, O'Regan L, Choi J, Sampson J, Pashley SL, Bayliss R, Khan S, Fry AM (2022) EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity. Mol Cancer Res. 20:854-866. PubMed.
Richardson A, Ciampani V, Stancu M, Bondarenko K, Newton S, Steinert JR, Pilati N, Graham BP, Kopp-Scheinpflug C, Forsythe ID (2022) Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse. Elife. 11:e75219. doi: 10.7554/eLife.75219. PubMed.
Bird MF, Hebbes CP, Scott SWM, Willets J, Thompson JP, Lambert DG (2022) A novel bioassay to detect Nociceptin/Orphanin FQ release from single human polymorphonuclear cells. PLoS One.: 17(5):e0268868. doi: 10.1371/journal.pone.0268868. PubMed.
Passeri G, Northcote-Smith J, Perera R, Gubic N, Suntharalingam K. (2022) An Osteosarcoma Stem Cell Potent Nickel(II)-Polypyridyl Complex Containing Flufenamic Acid. Molecules. 27(10):3277. doi: 10.3390/molecules27103277. PubMed.
Al-Bayati M, Samarasinghe S (2022) Biofilm and Gene Expression Characteristics of the Carbapenem-Resistant Enterobacterales, Escherichia coli IMP, and Klebsiella pneumoniae NDM-1 Associated with Common Bacterial Infections. Int J Environ Res Public Health. 19(8):4788. doi: 10.3390/ijerph19084788. PubMed.
Johnson A, Iffland-Mühlhaus L, Northcote-Smith J, Singh K, Ortu F, Apfel UP, Suntharalingam K. (2022) A bioinspired redox-modulating copper(II)-macrocyclic complex bearing non-steroidal anti-inflammatory drugs with anti-cancer stem cell activity. Dalton Trans. 51(15):5904-5912. doi: 10.1039/d2dt00788f. PubMed.
Kamata T, Al Dujaily E, Alhamad S, So TY, Margaritaki O, Giblett S, Pringle JH, Le Quesne J, Pritchard C (2022) Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment. Dis Model Mech. 15(2):dmm049148. doi: 10.1242/dmm.049148. PubMed.
Passeri G, Northcote-Smith J, Suntharalingam K. (2022) Delivery of an immunogenic cell death-inducing copper complex to cancer stem cells using polymeric nanoparticles. RSC Adv. 12(9):5290-5299. doi: 10.1039/d1ra08788f. PubMed.
Giakomidi D, Bird MF, Guerrini R, Calo G, Lambert DG (2022) Fluorescent opioid receptor ligands as tools to study opioid receptor function. J Pharmacol Toxicol Methods.: 113:107132. doi: 10.1016/j.vascn.2021.107132. PubMed.
Alaqbi SS, Burke L, Guterman I, Green C, West K, Palacios-Gallego R, Cai H, Alexandrou C, Myint NNM, Parrott E, Howells LM, Higgins JA, Jones DJL, Singh R, Britton RG, Tufarelli C, Thomas A, Rufini A (2022) Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells. PLoS One. 17:e0262364. doi: 10.1371/journal.pone.0262364. PubMed.
Collier MEW, Ambrose AR, Goodall AH (2022) Does hsa-miR-223-3p from platelet-derived extracellular vesicles regulate tissue factor expression in monocytic cells? Platelets. doi: 10.1080/09537104.2022.2027903. PubMed.
Hindul NL, Jhita A, Oprea DG, Hussain TA, Gonchar O, Campillo MAM, O'Regan L, Kanemaki MT, Fry AM, Hirota K, Tanaka K (2022) Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes. Biol Open. :bio.059056. doi: 10.1242/bio.059056. PubMed.
Bird MF, McDonald J, Horley B, O'Doherty JP, Fraser B, Gibson CL, Guerrini R, Caló G, Lambert DG (2022) MOP and NOP receptor interaction: Studies with a dual expression system and bivalent peptide ligands. PLoS One.: 17(1):e0260880. doi: 10.1371/journal.pone.0260880. PubMed.
2021
Wanford JJ, Hames RG, Carreno D, Jasiunaite Z, Chung WY, Arena F, Di Pilato V, Straatman K, West K, Farzand R, Pizza M, Martinez-Pomares L, Andrew PW, Moxon ER, Dennison AR, Rossolini GM, Oggioni MR (2021) Interaction of Klebsiella pneumoniae with tissue macrophages in a mouse infection model and ex-vivo pig organ perfusions: an exploratory investigation. The Lancet Microbe, DOI: 10.1016/S2666-5247(21)00195-6. PubMed.
Blockley A, Ogle D, Woodrow C, Montealegre-Z F, Warren B (2021) Physiological changes throughout the ear due to age and noise - a longitudinal study. bioRxiv 2021.11.25.470017; doi: 10.1101/2021.11.25.470017.
Poblocka M, Bassey AL, Smith VM, Falcicchio M, Manso AS, Althubiti M, Sheng X, Kyle A, Barber R, Frigerio M, Macip S (2021) Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker. Sci Rep. 11(1):20358. doi: 10.1038/s41598-021-99852-2. PubMed.
Xiao Z, Passeri G, Northcote-Smith J, Singh K, Suntharalingam K (2021) Osteosarcoma Stem Cell Potent Gallium(III)-Polypyridyl Complexes Bearing Diflunisal. Chemistry. 27(55):13846-13854. doi: 10.1002/chem.202102207. PubMed.
Pearce AC, Bamford MJ, Barber R, Bridges A, Convery MA, Demetriou C, Evans S, Gobbetti T, Hirst DJ, Holmes DS, Hutchinson JP, Jayne S, Lezina L, McCabe MT, Messenger C, Morley J, Musso MC, Scott-Stevens P, Manso AS, Schofield J, Slocombe T, Somers D, Walker AL, Wyce A, Zhang XP, Wagner SD (2021) GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice. J Biol Chem. 297:100928. doi: 10.1016/j.jbc.2021.100928. PubMed.
Darweesh O, Al-Shehri E, Falquez H, Lauterwasser J, Edlich F, Patel R. (2021) Identification of a novel Bax-Cdk1 signalling complex that links activation of the mitotic checkpoint to apoptosis. J Cell Sci. 134. PubMed.
Carreno D, Wanford JJ, Jasiunaite Z, Hames RG, Chung WY, Dennison AR, Straatman K, Martinez-Pomares L, Pareek M, Orihuela CJ, Restrepo MI, Lim WS, Andrew PW, Moxon ER, Oggioni MR (2021) Splenic macrophages as the source of bacteraemia during pneumococcal pneumonia. EBioMedicine. 72:103601. doi: 10.1016/j.ebiom.2021.103601. Epub ahead of print. PubMed.
Margaritis M, Saini F, Baranowska-Clarke AA, Parsons S, Vink A, Budgeon C, Allcock N, Wagner BE, Samani NJ, von der Thüsen J, Robertus JL, Sheppard MN, Adlam D (2021) Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. Cardiovasc Res. 2021 May 28:cvab183. doi: 10.1093/cvr/cvab183. PubMed.
Giakomidi D, Bird MF, McDonald J, Marzola E, Guerrini R, Chanoch S, Sabu N, Horley B, Calo G, Lambert DG (2021) Evaluation of [Cys(ATTO 488)8]Dermorphin-NH2 as a novel tool for the study of μ-opioid peptide receptors. PLoS One. 16:e0250011. doi: 10.1371/journal.pone.0250011. PubMed.
Zhang M, Luo JL, Sun Q, Harber J, Dawson AG, Nakas A, Busacca S, Sharkey AJ, Waller D, Sheaff MT, Richards C, Wells-Jordan P, Gaba A, Poile C, Baitei EY, Bzura A, Dzialo J, Jama M, Le Quesne J, Bajaj A, Martison L, Shaw JA, Pritchard C, Kamata T, Kuse N, Brannan L, De Philip Zhang P, Yang H, Griffiths G, Wilson G, Swanton C, Dudbridge F, Hollox EJ, Fennell DA (2021) Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment. Nat Commun. 12:1751. PubMed.
Busacca S, O'Regan L, Singh A, Sharkey AJ, Dawson AG, Dzialo J, Parsons A, Kumar N, Schunselaar LM, Guppy N, Nakas A, Sheaff M, Mansfield AS, Janes SM, Baas P, Fry AM, Fennell DA (2021) BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma. Mol Cancer Ther. 20:379-388. PubMed.
Miles GJ, Powley I, Mohammed S, Howells L, Pringle JH, Hammonds T, MacFarlane M, Pritchard C (2021) Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants. Lab Invest. 101:396-407. PubMed.
Viticchié G, Powley I, Demetriou C, Cooper J, Butterworth M, Patel M, Abid N, Miles G, Howells L, Pringle H, MacFarlane M, Pritchard C (2021) Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients. J Vis Exp Feb 7: (168) doi: 10.3791/62130. PubMed.
Collins A, Miles GJ, Powley IR, Hew R, Pringle JH, MacFarlane M, Pritchard C, Moss EL (2021) Development of a patient-derived explant model for prediction of drug responses in endometrial cancer. Gynecol Oncol. 160: 557 - 567. PubMed.
2020
Blbas S, Watson E, Butler H, Brown J, Herbert TP, Stover CM, Bevington A, Abbasian N (2020) Dexamethasone acutely suppresses the anabolic SNAT2/SLC38A2 amino acid transporter protein in L6‐G8C5 rat skeletal muscle cells. FASEB Bioadv. 3:36-48. PubMed.
Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F (2020) A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics. PLoS Genet. e1009129. PubMed.
Abbasian N, Bevington A, Burton JO, Herbert KE, Goodall AH, Brunskill NJ (2020) Inorganic Phosphate (Pi) Signaling in Endothelial Cells: A Molecular Basis for Generation of Endothelial Microvesicles in Uraemic Cardiovascular Disease. Int J Mol Sci.: 6993 PubMed.
Cellot G, Vranic S, Shin Y, Worsley R, Rodrigues AF, Bussy C, Casiraghi C, Kostarelos K, McDearmid JR (2020) Graphene oxide nanosheets modulate spinal glutamatergic transmission and modify locomotor behaviour in an in vivo zebrafish model. Nanoscale Horiz. 5:1250-1263. PubMed.
Delfino L, Mason RP, Kyriacou CP, Giorgini F, Rosato E (2020) Rab8 promotes mutant HTT aggregation, reduces neurodegeneration, and ameliorates behavioural alterations in a Drosophila model of Huntington's Disease. J. Huntingtons Dis. 9:253-263. PubMed.
Kamata T, So TY, Ahmed Q, Giblett S, Patel B, Luo J, Reddel R, Pritchard C (2020) Fibroblast-derived STC-1 modulates tumor-associated macrophages and lung adenocarcinoma development. Cell Rep. 2020 Jun 23;31(12):107802. doi: 10.1016/j.celrep.2020.107802. PubMed.
Turnbull RE, Fairall L, Saleh A, Kelsall E, Morris KL, Ragan TJ, Savva CG, Chandru A, Millard CJ, Makarova OV, Smith CJ, Roseman AM, Fry AM, Cowley SM, Schwabe JWR (2020) The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun 11:3252 - 3266. PubMed.
Warren B, Fenton GE, Klenschi E, Windmill JFC, French AS (2020) Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear. J Neurosci. 40(15):3130-3140. doi: 10.1523/JNEUROSCI.2279-19.2019. PubMed
Durmort C, Ercoli G, Ramos-Sevillano E, Chimalapati S, Haigh RD, De Ste Croix M, Gould K, Hinds J, Guerardel Y, Vernet T, Oggioni M, Brown JS (2020) Deletion of the zinc transporter lipoprotein AdcAII causes hyperencapsulation of Streptococcus pneumoniae associated with distinct alleles of the type I restriction-modification system. mBio 11:e00445-20. PubMed.
O’Regan L, Barone G, Adib R, Woo CG, Jeong HJ, Richardson EL, Richards MW, Muller PAJ, Collis SJ, Fennell DA, Choi J, Bayliss R, Fry AM (2020) EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7. J Cell Sci jcs.241505 doi: 10.1242/jcs.241505. PubMed.
Powley IR, Patel M, Miles G, Pringle H, Howells L, Thomas A, Kettleborough C, Bryans J, Hammonds T, MacFarlane M, Pritchard C (2020) Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery. Br J Cancer. 122:735-744. PubMed.
Mitsi E, Carniel B, Reiné J, Rylance J, Zaidi S, Soares-Schanoski A, Connor V, Collins AM, Schlitzer A, Nikolaou E, Solórzano C, Pojar S, Hill H, Hyder-Wright AD, Jambo KC, Oggioni MR, De Ste Croix M, Gordon SB, Jochems SP, Ferreira DM (2020) Nasal Pneumococcal density is associated with microaspiration and Heightened human alveolar macrophage responsiveness to bacterial pathogens. Am J Respir Crit Care Med. 201:335-347. PubMed.
Ekpenyong-Akiba AE, Poblocka M, Althubiti M, Rada M, Jurk D, Germano S, Kocsis-Fodor G, Shi Y, Canales JJ, Macip S (2020) Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition. Aging Cell. 2020:e13079.
2019
Stylianou P, Clark K, Gooptu B, Smallwood D, Brightling CE, Amrani Y, Roach KM, Bradding P (2019) Tensin1 expression and function in chronic obstructive pulmonary disease. Sci Rep 9: 18942. PubMed.
Hansen CN, Özkaya Ö, Roe H, Kyriacou CP, Giongo L, Rosato E (2019) Locomotor behaviour and clock neurons organisation in the agricultural pest Drosophila suzukii. Physiol. 10:941.doi: 10.3389/fphys.2019.00941. PubMed.
Adib R, Montgomery JM, Atherton J, O'Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM (2019) Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. Sci. Signal. 12, eaaw2939. PubMed.
Aravani D, Morris GE, Jones PD, Tattersall HK, Karamanavi E, Kaiser MA, Kostogrys RB, Najafabadi MG, Andrews SL, Nath M, Ye S, Stringer EJ, Samani NJ, Webb TR (2019) HHIPL1, a gene at the 14q32 coronary artery disease locus, positively Regulates hedgehog signaling and promotes atherosclerosis. Circulation 140: 500–513. PubMed.
Al-Ismaeel Q , Neal CP, Al-Mahmoodi H, Almutairi Z, Al-Shamarti I, Straatman K, Jaunbocus N, Irvine A, Issa E, Moreman C, Dennison AR, Sayan AE, McDearmid J, Greaves P, Tulchinsky E, Kriajevska M (2019) ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins. British Journal of Cancer.
Ekpenyong-Akiba AE, Canfarotta F, Bashar Abd H, Poblocka M, Casulleras M, Castilla-Vallmanya L, Kocsis-Fodor G, Kelly ME, Janus J, Althubiti M, Piletska E, Piletskyc S, Macip S (2019) Detecting and targeting senescent cells using molecularly imprinted nanoparticles. Nanoscale Horiz. 4: 757-768. doi: 10.1039/c8nh00473k.
Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö EM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F (2019) The Parkinson's disease-linked protein DJ-1 associates with cytoplasmic mRNP granules during stress and neurodegeneration. Mol Neurobiol 56:61-77. doi: 10.1007/s12035-018-1084-y. PubMed.
O’Regan L, Barone G, Adib R, Woo CG, Jeong HJ, Richardson EL, Richards MW, Muller PAJ, Collis SJ, Fennell DA, Choi J, Bayliss R, Fry AM (2019) EML4-ALK V3 drives cell migration through NEK9 and NEK7 kinases in non-small-cell lung cancer. bioRxiv.
2018
Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, Straatman K, Luo J, Balmanno K, Jones DTW, Collins VP, Cook SJ, Caunt CJ, Pritchard C (2018) Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK. Heliyon. 4:e01065. PubMed.
Adib R, Montgomery JM, Atherton J, O'Regan L, Richards M, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM (2018) Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression. Sci Signal. 12(594). pii: eaaw2939. PubMed.
Bird MF, Guerrini R, Willets JM, Thompson JP, Caló G, Lambert DG (2018) Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594; a novel fluorescent probe for the NOP receptor. Br J Pharmacol. doi: 10.1111/bph.14504. PubMed.
Chung WY, Wanford JJ, Kumar R, Isherwood JD, Haigh RD, Oggioni MR, Dennison AR, Ercoli G (2018) An ex vivo porcine spleen perfusion as a model of bacterial sepsis. ALTEX. 2018 Aug 3. doi: 10.14573/altex.1805131. PubMed.
Jones PD, Kaiser MA, Ghaderi Najafabadi M, Koplev S, Zhao Y, Douglas G, Kyriakou T, Andrews S, Rajmohan R, Watkins H, Channon KM, Ye S, Yang X, Björkegren JLM, Samani NJ, Webb TR (2018) JCAD, a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells. Arterioscler Thromb Vasc Biol. 38:1711-1722. PubMed.
Mukherjee M, Sabir S, O'Regan L, Sampson J, Richards MW, Huguenin-Dezot N, Ault JR, Chin JW, Zhuravleva A, Fry AM, Bayliss R (2018) Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release. Sci Signal. 14; 11(543): eaao2464. PubMed.
Al-Osta I, Mucha M, Pereda D, Piqué-Gili M, Okorocha AE, Thomas R, Hartell NA (2018) Imaging calcium in hippocampal presynaptic terminals with a ratiometric calcium sensor in a novel transgenic mouse. Front Cell Neurosci. 12:209. doi: 10.3389/fncel.2018.00209. PubMed.
Warren B, Matheson T (2018) The role of the mechanotransduction ion channel candidate nanchung-inactive in auditory transduction in an insect ear. J Neurosci. 38:3741-3752. PubMed.
Kelsall EJ, Vertesy A, Straatman K, Tariq M, Gadea R, Parmar C, Schreiber G, Randhawa S, Dominguez C, Klipp E, Tanaka K (2018) Constitutively active RAS in S. pombe causes persistent Cdc42 signalling but only transient MAPK activation. bioRxiv.
Ercoli G , Fernandes VE, Chung WY, Wanford JJ, Thomson S, Christopher D. Bayliss, Straatman K, Crocker PR, Dennison A, Martinez-Pomares L, Andrew PW, Moxon ER, Oggioni MR (2018) Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia. Nature Microbiology: doi:10.1038/s41564-018-0147-1. PubMed.
2017
Fry AM, Bayliss R, Roig J (2017) Mitotic Regulation by NEK Kinase Networks.Front Cell Dev Biol. 1: 102. doi: 10.3389/fcell.2017.00102. PubMed.
Elgamoudi BA, Ketley JM (2017) Lighting up my life: a LOV-based fluorescent reporter for Campylobacter jejuni. Res Microbiol. pii: S0923-2508(17)30169-9. PubMed.
Rada M, Althubiti M, Ekpenyong-Akiba AE, Lee KG, Lam KP, Fedorova O, Barlev NA, Macip S (2017) BTK blocks the inhibitory effects of MDM2 on p53 activity.Oncotarget. 8:106639-106647. PubMed.
Sampson J, O'Regan L, Dyer MJS, Bayliss R, Fry AM (2017) Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.Cancer Res. 77:4785-4796. PubMed.
Collier MEW, Ettelaie C, Goult BT, Maraveyas A, Goodall AH (2017) Investigation of the filamin A–dependent mechanisms of tissue factor incorporation into microvesicles. Thromb Haemost ; 117: 2034-2044. PubMed.
Kamata T, Giblett S, Pritchard C (2017) KRASG12D expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment. Blood. doi: 10.1182/blood-2017-02-770149. PubMed.
Rada M, Vasileva E, Lezina L, Marouco D, Antonov AV, Macip S, Melino G, Barlev NA (2017) Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene.36:922-932. PubMed.
Sepsi A, Higgins JD, Heslop-Harrison JS, Schwarzacher T (2017) CENH3 morphogenesis reveals dynamic centromere associations during synaptonemal complex formation and the progression through male meiosis in hexaploid wheat. Plant J. 89: 235-249. PubMed.
2016
Samuel J, Jayne S, Chen Y, Majid A, Wignall A, Wormull T, Najeeb H, Luo JL, Jones GDD, Macip S, Dyer MJS (2016) Posttranscriptional Upregulation of p53 by Reactive Oxygen Species in Chronic Lymphocytic Leukemia. Cancer Res 76: 6311 - 6319. PubMed.
Althubiti M, Rada M, Samuel J, Escorsa JM, Najeeb H, Lee KG, Lam KP, Jones GD, Barlev NA, Macip S (2016) BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses. Cancer Res. 76:5405 - 5414. PubMed.
Nale JY, Chutia M, Carr P, Hickenbotham PT, Clokie MR (2016) 'Get in Early'; Biofilm and wax moth (Galleria mellonella) models reveal new insight into the therapeutic potential of clostridium defficile bacteriophages. Front Microbiol 1383. doi: 10.3389/fmicb.2016.01383. eCollection 2016. PubMed.
Banushi B, Forneris F, Straatman-Iwanowska A, Strange A, Lyne AM, Rogerson C, Burden JJ, Heywood WE, Hanley J, Straatman KR, Smith H, Bem D, Kriston-Vizi J, Ariceta G, Risteli M, Wang C, Waddington SN, Howe SJ, Ferraro F, Gjinovci A, Lawrence S, Marsh M, Girolami M, Bozec L, Mills K, Gissen P (2016) Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nature Communications. PubMed.
Jones PD, Kaiser MA, Ghaderi Najafabadi M, McVey DG, Beveridge AJ, Schofield CL, Samani NJ, Webb TR (2016) The coronary artery disease associated coding variant in zinc finger C3HC-type containing 1 (ZC3HC1) affects cell cycle regulation. J Biol Chem. 291: 16318-16327. PubMed.
Bakali E, McDonald J, Elliott RA, Lambert DG, Tincello DG (2016) Cannabinoid receptor expression in the bladder is altered in detrusor overactivity. Int Urogynecol J 27: 129–139. PubMed.
2015
Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R (2015) Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization. Nat Commun. 6:8771. doi: 10.1038/ncomms9771. PubMed.
Sabir SR, Sahota NK, Jones GD, Fry AM (2015) Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents. PLOS ONE 10:e0140975. doi: 10.1371. PubMed.
Roach KM, Feghali-Bostwick CA, Amrani Y, Bradding P (2015) Lipoxin A4 Attenuates Constitutive and TGF-β1–Dependent Profibrotic Activity in Human Lung Myofibroblasts. J Immunol. 195: 2852–2860. PubMed.
Kamata T, Jin H, Giblett S, Patel F, Patel F, Foster C, Pritchard C (2015) The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours. EMBO Mol Med. 2015 Jul 16. pii: e201404838. doi: 10.15252/emmm.201404838. PubMed.
Prosser SL, Sahota NK, Pelletier L, Morrison CG, Fry AM (2015) Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis. J Cell Biol. 209:339-348. PubMed.
O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM (2015) Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J Cell Biol. 209: 349-358. PubMed.
Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R (2015) Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain. Biochem J. 467: 529-536. PubMed.
Jay M, De Faveri F, McDearmid JR (2015) Firing dynamics and modulatory actions of supraspinal dopaminergic neurons during zebrafish locomotor behaviour. Curr Biol. 25:435-44. PubMed.
Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F (2015) Rab11 modulates α-synuclein mediated defects in synaptic transmission and behaviour. Hum Mol Genet 24: 1077-1091. PubMed.
2014
Roach KM, Wulff H, Feghali-Bostwick C, Amrani Y, Bradding P (2014) Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent. Respir Res. 15: 155. PubMed.
Dissel S, Hansen CN, Ozkaya O, Hemsley M, Kyriacou CP, Rosato E (2014) The logic of circadian organization in Drosophila. Curr Biol. 24: 2257-2266. doi: 10.1016/j.cub.2014.08.023. PubMed.
Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard CA, Cain K, Macip S (2014) Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. 20:e1528. PubMed.
Patel JT, Bottrill A, Prosser SL, Jayaraman S, Straatman K, Fry AM, Shackleton S (2014) Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact. Nucleus 5: 462 - 473. PubMed.
Meinke P, Mattioli E, Haque F, Antoku S, Columbaro M, Straatman KR, Worman HJ, Gundersen GG, Lattanzi G, Wehnert M and Shackleton S (2014) Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization. PLoS Genet. 10(9):e1004605. PubMed.
Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF (2014) DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease. Cell Death Dis. 5, e1350; doi:10.1038/cddis.2014.307. PubMed.
Jamaladdin S, Kelly RD, O'Regan L, Dovey OM, Hodson GE, Millard CJ, Portolano N, Fry AM, Schwabe JW, Cowley SM (2014) Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proc. Natl. Acad. Sci. USA. 111: 9840-9845. PubMed.
Hardy T, Lee M, Hames RS, Prosser SL, Cheary DM, Samant MD, Schultz F, Baxter JE, Rhee K, Fry AM (2014) Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction. J Cell Sci. 127: 2493-2506. PubMed.
Carrera S, Senra J, Acosta MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S (2014) The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions. PLoS One. 9:e97938. PubMed.
Moiseeva EP, Straatman KR, Leyland ML and Bradding P (2014) CADM1 Controls Actin Cytoskeleton Assembly and Regulates Extracellular Matrix Adhesion in Human Mast Cells. PLOS ONE 9: e85980. PubMed.
Ahmed SB, Prigent SA (2014) A nuclear export signal and oxidative stress regulate ShcD subcellular localisation: a potential role for ShcD in the nucleus. Cell Signal. 26:32-40. PubMed.
Jay M, Bradley S, McDearmid JR (2014) Effects of nitric oxide on neuromuscular properties of developing zebrafish embryos. PLoS One. 9(1):e86930. PubMed.
2013
Dhani DK, Goult BT, George GM, Rogerson DT, Bitton DA, Miller CJ, Schwabe JW and Tanaka K (2013) Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6). Mol Biol Cell. 24:3337-3349. PubMed.
Goult BT, Xu XP, Gingras AR, Swift M, Patel B, Bate N, Kopp PM, Barsukov IL, Critchley DR, Volkmann N, Hanein D (2013) Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.J Struct Biol. 184:21-32. PubMed.
Blakemore LM, Boes C, Cordell R and Manson MM (2013) Curcum in-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage. Carcinogenesis. 34:351-60. PubMed.
Cooke RM, Mistry R, Challiss RA and Straub VA (2013) Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy. J Neurosci. 33: 5626-37. PubMed.
Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW, Macip S (2013) Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ 20:910-9. PubMed.
Watkins RJ, Patil R, Goult BT, Thomas MG, Gottlob I, and Shackleton S (2013) A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus. Hum Mol Genet. Feb 20. PubMed.
Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB and Cohen GM (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8:e56603. PubMed.
Raschpichler M, Straatman K, Pampel A, Schroeter ML, Arelin K, Schloegl H, Fritzsch D, Mende M, Stumvoll M, Villringer A and Mueller K (2013) Abdominal fat distribution and its relationship to brain changes - the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study. BMJopen;3:e001915. PubMed.
Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF and Giorgini F (2013) Parkinson’s disease-associated mutations in DJ-1 modulate its dimerization in living cells. J. Mol. Med. 91:599-611. PubMed.
Venoux M, Tait X, Hames RS, Straatman KR, Woodland HR and Fry AM (2013) Poc1A and Poc1B act together in human cells to ensure centriole integrity. J Cell Sci. 126: 163-175. PubMed.
2012
Prosser SL, Samant MD, Baxter JE, Morrison CG and Fry AM (2012) Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. J Cell Sci. 125: 5353-5368. PubMed.
Andreadi C, Cheung LK, Giblett S, Patel B, Jin H, Mercer K, Kamata T, Lee P, Williams A, McMahon M, Marais R and Pritchard C (2012) The intermediate-activity L597V-BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev.; 26: 1945–1958. PubMed.
Funaya C, Samarasinghe S, Pruggnaller S, Ohta M, Connolly Y, Jan Müller J Murakami H, Grallert A, Yamamoto M, Smith D, Antony C and Tanaka K (2012) Transient Structure Associated with the Spindle Pole Body Directs Meiotic Microtubule Reorganization in S. pombe. Current Biology 22: 562-574. PubMed.
Lalo U, Jones S, Roberts JA, Mahaut-Smith MP and Evans RJ (2012) Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness. J Biol Chem. 287: 32747-32754. PubMed.
Baines RJ, Chana RS, Hall M, Febbraio M, Kennedy D, Brunskill NJ (2012) CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies. Am J Physiol Renal Physiol. 303:F1006-14. PubMed.
Elliott PR, Irvine AF, Jung HS, Tozawa K, Pastok MW, Picone R, Badyal SK, Basran J, Rudland PS, Barraclough R, Lian L-Y, Bagshaw CR, Kriajevska M and Barsukov IL (2012) Asymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling. Structure 20: 654-666. PubMed.
Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S (2012) Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. Biol Chem. 287:9845-54 PubMed.
Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ (2012) New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur J Cell Biol. 91: 180-191. PubMed.
Zalli D, Bayliss R, Fry AM (2012) The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis. Hum Mol Genet. 21: 1155-1171. PubMed.
2011
Sylvius N, Bonne G, Straatman K, Reddy T, Gant TW and Shackleton S (2011) MicroRNA expression profiling in patients with lamin A/C associated muscular dystrophy. FASEB J. 25:3966-3978. PubMed.
Smith E, Hégarat N, Vesely C, Roseboom I, Larch C, Streicher H, Straatman K, Flynn H, Skehel M, Hirota T, Kuriyama R and Hochegger H (2011) Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1. EMBO J. 30: 2233-2245. PubMed.
van de Ven C, Bialecka M, Neijts R, Young T, Rowland JE, Stringer EJ, Van Rooijen C, Meijlink F, Nóvoa A, Freund JN, Mallo M, Beck F, Deschamps J (2011) Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development. 138:3451-62. PubMed.
Thomas MG, Kumar A, Thompson JR, Proudlock FA, Straatman K, and Gottlob I (2011) Is high-resolution spectral domain optical coherence tomography reliable in nystagmus? Br J Ophthalmol 2011-300476. PubMed.
Lopes CA, Prosser SL, Romio L, Hirst RA, O'Callaghan C, Woolf AS and Fry AM (2011) Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1. J Cell Sci. 124:600-12. PubMed.
Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA and Critchley DR (2011) Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol. 349:494-502. PubMed.
2010 - 2005
Cruse G, Yang W, Duffy SM, Chachi L, Leyland M, Amrani Y and Bradding P (2010) Counterregulation of b2-adrenoceptor function in human mast cells by stem cell factor. J. Allergy Clin. Immunol. 125:257-263. PubMed.
Lalo U, Allsopp RC, Mahaut-Smith MP and Evans RJ (2010) P2X1 receptor mobility and trafficking; regulation by receptor insertion and activation. J. Neurochem. 113: 1177-1187. PubMed.
Bradley S, Tossell K, Lockley R and McDearmid JR (2010) Nitric Oxide Synthase Regulates Morphogenesis of Zebrafish Spinal Cord Motoneurons. J. Neurosci. 30: 16818 –16831. PubMed.
Hayward DG, Newbatt Y, Pickard L, Byrne E, Mao G, Burns S, Sahota NK, Workman P, Collins I, Aherne W and Fry AM (2010) Identification by High-Throughput Screening of Viridin Analogs as Biochemical and Cell-Based Inhibitors of the Cell Cycle-Regulated Nek2 Kinase. J Biomol Screen. 15: 918-927. PubMed.
Kopp PM, Bate N, Hansen TM, Brindle NPJ, Praekelt U, Debrand E, Coleman S, Mazzeo D, Goult BT, Gingras AR, Pritchard CA, Critchley DR and Monkley SJ (2010) Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1. Eur. J. Cell Biol. 89: 661-673. PubMed.
Gingras A.R, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC and Critchley DR (2010) The central region of talin has a unique fold that binds vinculin and actin. J Biol Chem. 285:29577-29587. PubMed.
Clark K, Howe JD, Pullar CE, Green JA, Artym VV, Yamada KM and Critchley DR (2010) Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. J Cell Biochem. 109:808-817. PubMed.
Haque F, Mazzeo D, Patel JT, Smallwood DT, Ellis JA, Shannahan CM and Shackleton S (2010) Mammalian SUN protein networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 285: 3487-3498. PubMed.
Gehrig J, Reischl M, Kalmar E, Ferg M, Hadzhiev Y, Zaucker A, Song C, Schindler S, Liebel U and Müller F (2009) Automated high throughput mapping of promoter-enhancer interactions in zebrafish embryos. Nature Methods 6: 911 - 916. PubMed.
Sayan, A.E., Griffiths, T.R., Pal, R., Browne, G.B., Ruddick, A., Yagci, T., Edwards, R., Mayer, N.J., Qazi, H., Goyal, S., Fernandez, S., Straatman, K., Jones, G.D.D., Bowman, K.J., Colquhoun, A., Mellon, J.K., Kriajevska, M., and Tulchinsky, E. (2009) SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer. PNAS 106:14884-14889. PubMed.
O'Regan L. and Fry, A.M. (2009) The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis. Mol Cell Biol.;29:3975-3990. PubMed.
Prosser, S.L. and Fry, A.M. (2009) Fluorescence imaging of the centrosome cycle in mammalian cells. Methods in Molecular Biology 545: 165-183. PubMed.
Prosser, S.L., Straatman, K.R. and Fry, A.M. (2009) Molecular dissection of the centrosome overduplication pathway in S-phase arrested cells. Mol. Cell. Biol. 29: 1760-1773. PubMed.
Westwood, I., Cheary, D-M., Baxter, J.E., Richards, M.W., Fry, A.M. and Bayliss, R. (2009) Insights into the conformational variability and regulation of human Nek2 kinase. Journal of Molecular Biology 386: 476-485. PubMed.
Hames, R.S., Hames, R., Prosser, S.L., Euteneuer, U., Lopes, C.A.M., Moore, W., Woodland, H. and Fry, A.M. (2008) Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells. Experimental Cell Research 314: 574-589. PubMed.
Noble, C., Mercer, K., Hussain, J., Carragher, L., Giblett, S., Hayward, R., Patterson, C., Marais, R. and Pritchard, C.A. (2008) CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. Molecular Cell 31: 862-872. PubMed.
Pattrick, M., Luckett, J., Yue, L. and Stover, C. (2008) Dual role of complement in adipose tissue. Mol Immunol. october. PubMed.
Stover, C.M., Luckett, J.C., Echtenacher, B., Dupont, A., Figgitt, S.E., Brown, J., Männel, D.N. and Schwaeble, W.J. (2008) Properdin plays a protective role in polymicrobial septic peritonitis. J Immunol. 180:3313-3318. PubMed.
Wickenden, J.A., Jin, H., Johnson, M., Gillings, A.S., Newson, C., Austin, M., Chell, S.D., Balmanno, K., Pritchard, C.A. and Cook S.J. (2008) Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. Oncogene 27: 7150-7161. PubMed.
Codd V., D. Dolezel, J. Stehlik, A. Piccin, K.J. Garner, S.N. Racey, K.R. Straatman, E.J. Louis, R. Costa, I. Sauman, C.P. Kyriacou, E. Rosato (2007) Circadian Rhythm Gene Regulation in the Housefly Musca domestica. Genetics 177(3): 1539-5. PubMed.
Rellos, P., Ivins, F.J., Baxter, J.E., Pike, A., Nott, T.J., Parkinson, D-M., Das, S., Howell, S., Federov, O., Shen, Q.Y., Fry, A.M., Knapp, S. and Smerdon, S.J. (2007) Structure and regulation of the human Nek2 centrosomal kinase. Journal of Biological Chemistry 282: 6833-6842. PubMed.
Wu, W., Baxter, J.E., Wattam, S.L., Hayward, D.G., Fardilha, M., Knebel, A., Ford, E.M., da Cruz e Silva, E.F. and Fry, A.M. (2007) Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase. Journal of Biological Chemistry 282: 26431-26440. PubMed.
Haque, F., Lloyd, D.J., Smallwood, D.T., Dent, C., Shanahan, C.M., Fry, A.M., Trembath, R.C. and Shackleton, S. (2006) SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Molecular and Cellular Biology 26: 3738-3751. PubMed.
Hayes, M.J., Kimata, Y., Wattam, S.L., Lindon, C., Mao, G., Yamano, H. and Fry, A.M. (2006) Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C. Nature Cell Biology 8: 607-614. PubMed.
Hames, R.S., Crookes, R.E., Hayes, M.J., Straatman, K.R., Merdes, A., Faragher, A.J. and Fry, A.M. (2005) Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1 and localized proteasomal degradation. Molecular Biology of the Cell 16: 1711-1724. PubMed.
Mercer, K., Giblett, S., Oakden, A., Brown, J., Marais, R. and Pritchard, C. (2005) A-Raf and Raf-1 work together to influence transient ERK phosphorylation and G1/S cell cycle progression. Oncogene 24:5207-5217. PubMed.
Mercer, K., Giblett, S., Green, S., Da Rocha Dias, S., Plumb, M., Marais, R. and Pritchard, C. (2005) Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Research 65: 11493-11500. PubMed.
Shackleton, S., Smallwood, D.T., Clayton, P., Wilson, L.C., Agarwal, A.K., Garg, A. and Trembath R.C. (2005) Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype. Journal of Medical Genetics 42: 36-42. PubMed.
Shu, X., Fry, A.M., Tulloch, B., Manson, F.D.C., Crabb, J.W., Khanna, H., Faragher, A.J., Lennon, A., He, S., Trojan, P., Giessl, A., Wolfrum, U., Swaroop, A., Vervoot, R. and Wright, A.F. (2005) RPGR ORF15 isoform co-localises with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin. Human Molecular Genetics 14: 1183-1197. PubMed.
Rapley, J., Baxter, J.E., Wattam, S.L., Casenghi, M., Meraldi, P., Nigg, E.A. and Fry, A.M. (2005) Coordinate regulation of the mother centriole component Nlp by Nek2 and Plk1 protein kinases. Molecular and Cellular Biology 25: 1309-1324. PubMed.
Wilson, G.M., Fielding, A.B., Simon, G.C., Yu, X., Andrews, P.D., Hames, R.S., Fry, A.M., Peden, A.A., Gould, G.W. and Prekeris, R. (2005) The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Molecular Biology of the Cell 16: 849-860. PubMed.
Publications arising from the Wellcome Trust Imaging grant (060514), 2004 - 2000
Hayward, D.G., Clarke, R.B., Faragher, A.J., Pillai, M.R., Hagan, I.M. and Fry, A.M. (2004) The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res. 64:7370-7376. PubMed.
Mistry, P., Deacon, K., Mistry, S., Blank, J. & Patel, R. (2004) NF-kB promotes survival during mitotic cell cycle arrest. J. Biol. Chem. 279: 1482-1490. PubMed.
Pritchard, C.A., Hayes, L., Wojnowski, L., Zimmer, A., Marais, R. & Norman, J.C. (2004) B-Raf acts via the ROCK II/LIMK/cofilin pathway to maintain actin stress fibres in fibroblasts. Mol Cell Biol. 24: 5937-5952. PubMed.
Roberts, M.S., Woods, A.J., Dale, T.C., Van Der Sluijs, P. and Norman, J.C. (2004) Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol Cell Biol. 24: 1505-1515. PubMed.
Romio, L., Fry, A.M., Winyard, P., Malcolm, S. Woolf, A. and Feather, S. (2004) OFD1 encodes a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human organogenesis. J. Am. Soc. Nephrol. 15:2556-68. PubMed.
Twomey, C., Wattam, S.L., Pillai, M.R., Rapley, J., Baxter, J.E. and Fry, A.M. (2004) Nek2B stimulates zygotic centrosome assembly in Xenopus laevis in a kinase-independent manner. Dev. Biol. 265: 384-398. PubMed.
Warnke, S., Kemmler, S., Hames, R.S., Tsai, H-L., Hoffmann-Rohrer, U., Fry, A.M. and Hoffmann, I. (2004) Polo-like kinase-2 is required for centriole duplication in mammalian cells. Curr. Biol. 14: 1200-1207. PubMed.
Woods, A.J., White, D.M., Caswell, P.T., and Norman, J.C. (2004) PKD/PKCm promotes avb integrin recycling and delivery to nascent focal adhesions. EMBO J. 23: 2531–2543. PubMed.
Deacon, K., Mistry, P., Chernoff, J., Blank, J. and Patel, R. (2003). p38 MAP kinase mediates cell death and p21-activated kinase (PAK) mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol. Biol. Cell. 14: 2071-2087. PubMed.
Faragher, A.J. and Fry, A.M. (2003) Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. Mol. Biol. Cell 14: 2876-2889. PubMed.
Giannone, G., Jiang, G., Sutton, D.H., Critchley, D.R. and Sheetz, M.P. (2003) Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J. Cell Biol. 163: 409-419. PubMed.
Hagemann, C., Patel, R. and Blank, J. (2003). MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome. Biochem. J. 73: 71-79. PubMed.
Roberts, M.S., Woods, A.J., Shaw, P.E. and Norman, J.C. (2003) ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin. J Biol Chem, 278: 1975-1985. PubMed.