LIFT-UP PRETERM

Long term Follow-up after Trials Using a European Platform of Preterm birth cohorts

The LIFT-UP Preterm project aims to create innovative tools and methods to promote Randomised Control Trials in very preterm populations using the RECAP Preterm platform. The ultimate aim is to generate knowledge for better health, development and quality of life for those affected by very preterm birth.

The LIFT-UP project will create a data entry tool integrated into the RECAP Preterm platform, based on the open source PARCA-R questionnaire, which is a parent completed questionnaire that can be used to assess children’s cognitive and language development at 24 months of age. Other tools relate to the analysis of trial data, making it possible to compare between trials and the cohorts on the platform. These will assess the “transportability” of trial results, meaning what effects can be expected when the trial interventions are applied to very preterm infants with characteristics that may differ from those included in the trial.

The new tools created for LIFT-UP Preterm will be implemented in a proof-of-concept study to follow up the TREOCAPA (Prophylactic treatment of the ductus arterious in preterm infants by acetaminophen) trial when the enrolled children are two years of age. TREOCAPA-Long-term (LT) is following up at the age of two the children who participated in the TREOCAPA trial using the online data tool created in LIFT-UP Preterm. The aim of TREOCAPA-LT is to determine whether the preventive use of paracetamol in preterm infants during the first five days of life is safe and effective in reducing the risk of neurodevelopmental disorders in early childhood.

People

Professor Samantha Johnson is an investigator on this project, providing guidance in the developmental follow-up of children at two years of age and use of the PARCA-R questionnaire. 

• For more information visit the LIFT-UP Preterm website