TIMMS: Improving outcomes for babies and children

TIMMS: Improving outcomes for babies and children

Explore the collaborations the TIMMS group at the University of Leicester are currently a part of.

Collaborations

Cooling in Mild Encephalopathy (COMET) Trail

2023 - 2029

The COMET Trial is funded by the NIHR and is designed to answer the question: Does whole-body hypothermia to 33.5 ±0.5°C, initiated within 6 hours of birth and continued for 72 hours, improve cognitive development at two years of age after mild Hypoxic Ischemic Encephalopathy (HIE) compared with targeted normothermia at 37.0 ± 0.5°C?


LIFT-UP PRETERM: Long term Follow-up after Trials Using a European Platform of Preterm birth cohorts

2023 - 2027

The LIFT-UP Preterm project aims to create innovative tools and methods to promote Randomised Control Trial's in very preterm populations using the RECAP Preterm platform. The ultimate aim is to generate knowledge for better health, development and quality of life for those affected by very preterm birth.


Bicarbonate for AcidosiS in very pretErm babies (BASE): A randomised clinical trial

2022 - 2029

The BASE trial is looking at the use of sodium bicarbonate for metabolic acidosis in very preterm babies. The project is designed to answer the question: In very preterm babies with metabolic acidosis, does using sodium bicarbonate or not impact their health and development in the short and long term?

 

OPTICAL: Optimising Paediatric Transition to Intensive Care for AduLts

2023 - 2026

Children with complex health care needs are frequently admitted to children's ICUs for life saving treatment. Advances in medical care and treatment mean that this group are now living longer lives. OPTICAL will gather data to inform how we can improve the quality, safety and experience of medical care for teenagers and young adults with complex health conditions when they are admitted to adult intensive care units. 


    Facilitating safe transition to home for preterm infants - a retrospective observational study (The FAST-Home Study)

    2023 - 2024

    Babies born preterm (before 37 completed weeks of pregnancy) need neonatal care but staying in hospital longer than necessary can be harmful to the baby and stressful and costly for families. There are no set rules about when it is safe for a preterm baby to go home. In this project we are exploring what reasons there are that keep babies in neonatal care. 


    The Monoclonal Antibody Medications in inflammatory Arthritis: stopping or continuing in pregnancy (MAMA) trial

    2023 - 2029

    The MAMA Trial is looking at whether stopping or continuing biologics in pregnancy is good or bad for women with inflammatory arthritis.


    Fluids Exclusively Entreal from Day 1 (FEED1): A randomised control trial of full milk feeds versus intravenous nutrition with gradual feeding for preterm infants (30-33 weeks gestational age)

    2021 - 2027

    The FEED1 trial is designed to investigate whether, in infants born at 30+0 to 32+6 weeks+days (inclusive) gestation, full milk feeds initiated in the first 24 hours of life reduce the length of hospital stay in comparison to IV fluids with gradual milk feeding. Infants will also be followed-up at two years of age to assess children’s developmental outcomes.


    Investigating the clinical and cost-effectiveness of a nutrient enriched diet for babies with a brain injury: The DOLFIN Randomised controlled trial

    2021 - 2026

    Babies who are born very early, or who suffer poor blood supply or lack of oxygen to the brain before or around birth, are more likely to have problems with their brain development and child neurological development. This may affect how children think and learn, communicate, play, and interact with the world around them.
    DOLFIN aims to answer the research question: In babies who are born very early or who suffer poor blood supply or lack of oxygen to the brain before or around birth, does giving a nutritional supplement daily for a year improve long-term cognitive development?

     

     

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