People

Dr Ranjit Arnold

Associate Professor of Cardiac Imaging and Honorary Consultant Cardiologist

School/Department: Cardiovascular Sciences, Department of

Email: jra14@le.ac.uk

Profile

I am an Associate Professor of Cardiac Imaging and Honorary Consultant Cardiologist based at the Department of Cardiovascular Sciences at the NIHR Leicester Biomedical Research Centre (BRC), supported by an NIHR EME Fellowship. My research focuses on the application of advanced cardiovascular magnetic resonance (CMR) techniques to improve the diagnosis and management of coronary artery disease. I have a particular interest myocardial perfusion imaging and the development of accelerated imaging protocols to enhance clinical feasibility. My work integrates clinical cardiology with imaging innovation and artificial intelligence, and I have a strong track record in leading prospective, diagnostic accuracy studies.

Research

My research centres on the use of advanced imaging techniques to improve the diagnosis and management of coronary artery disease. This includes the use of visual and quantitative cardiovascular magnetic resonance perfusion imaging, oxygenation-sensitive MRI, and artificial intelligence approaches for image analysis. I have a strong track record in leading prospective diagnostic accuracy trials, including studies comparing CMR perfusion imaging with CT-derived fractional flow reserve (CT-FFR), as well as the development and evaluation of accelerated CMR techniques. I am Chief Investigator of the NIHR-funded ACCELERATE-CMR trial, a multicentre study evaluating accelerated CMR in patients with suspected coronary artery disease.

Publications

  • Accelerated stress CMR for the detection of significant coronary artery disease: a prospective randomized diagnostic accuracy study. Elshibly M, Shergill S, Velvet A, Gohar A, Pattani S, Parke KS, England R, Moafi A, Hudson G, Khoo J, O'Regan DP, Wu O, Adlam D, Kellman P, McIntosh A, McConnachie A, Ladwiniec A, McCann GP, Arnold JR. Eur Heart J Cardiovasc Imaging. 2025 Nov 20:jeaf322. doi:10.1093/ehjci/jeaf322. PMID:41264815.
  • Stress T1 mapping for the detection of obstructive coronary artery disease: a prospective diagnostic accuracy study. Shergill S, Elshibly M, Velvet A, Moafi A, England R, Parke KS, Wormleighton JV, Adlam D, Hothi SS, Kellman P, McIntosh A, McConnachie A, Ladwiniec A, McCann GP, Arnold JR. J Cardiovasc Magn Reson. 2026 Jan 29:102701. doi:10.1016/j.jocmr.2026.102701. PMID: 41619975.
  • Interactive Deep Learning for Myocardial Scar Segmentation Using Cardiovascular Magnetic Resonance. Moafi A, Moafi D, Shergill S, Mirkes EM, Adlam D, Samani NJ, McCann GP, Ghazi MM, Arnold JR. J Cardiovasc Magn Reson. 2026 Mar 19:102720. doi: 10.1016/j.jocmr.2026.102720. Epub ahead of print. PMID: 41864346.
  • Cardiovascular magnetic resonance versus coronary computed tomography angiography with fractional flow reserve for diagnosing obstructive coronary artery disease in higher risk patients: rationale and design of the CONCORD-A prospective diagnostic accuracy study. Shergill S, Elshibly M, Parke KS, England R, Wormleighton JV, Das I, Gulsin GS, Hothi SS, Heggie R, Wu O, Kellman P, McIntosh A, McConnachie A, Ladwiniec A, McCann GP, Arnold JR. J Cardiovasc Magn Reson. 2025 Aug 14;28(1):101939. doi:10.1016/j.jocmr.2025.101939. PMID:40818667.
  • Assessing the impact of COmorbidities and Sociodemographic factors on Multiorgan Injury following COVID-19: rationale and protocol design of COSMIC, a UK multicentre observational study of COVID-negative controls. Shergill S, Elshibly M, Hothi SS, Parke KS, England RJ, Wormleighton JV, Hudson GJ, Tunnicliffe EM, Wild J, Smith SM, Francis S, Toshner M, Sattar N, Khunti K, Brightling CE, Antoniades C, Berry C, Greenwood JP, Moss A, Neubauer S, McCann GP, Raman B, Arnold JR. BMJ Open. 2025 Mar 6;15(3):e089508. doi: 10.1136/bmjopen-2024-089508. PMID: 40050066
  • Arnold JR, Yeo JL, Budgeon CA, Shergill S, England R, Shiwani H, Artico J, Moon JC, Gorecka M, Roditi G, Morrow A, Mangion K, Shanmuganathan M, Miller CA, Chiribiri A, Alzahir M, Ramirez S, Lin A, Swoboda PP, McDiarmid AK, Sykes R, Singh T, Bucciarelli-Ducci C, Dawson D, Fontana M, Manisty C, Treibel TA, Levelt E, Young R, McConnachie A, Neubauer S, Piechnik SK, Davies RH, Ferreira VM, Dweck MR, Berry C; Oxford Acute Myocardial Infarction OxAMI Study Investigators; COVID-HEART investigators; McCann GP, Greenwood JP. Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study. Int J Cardiovasc Imaging. 2025 Feb;41(2):247-256. doi: 10.1007/s10554-024-03304-7. Epub 2024 Dec 30. PMID: 39738791; PMCID: PMC11811239.
  • Arnold JR, Kanagala P, Budgeon CA, Jerosch-Herold M, Gulsin GS, Singh A, Khan JN, Chan DCS, Squire IB, Ng LL, McCann GP. Prevalence and prognostic significance of microvascular dysfunction in heart failure with preserved ejection fraction. JACC Cardiovascular Imaging JACC Cardiovasc Imaging. 2022 Jan 5:S1936-878X(21)00893-7. doi: 10.1016/j.jcmg.2021.11.022. PMID: 35033490
  • Arnold JR, McCann GP. Cardiovascular magnetic resonance: applications and practical considerations for the general cardiologist. Heart. 2020 Feb;106(3):174-181. doi: 10.1136/heartjnl-2019-314856. Epub 2019 Dec 11. PMID: 31826937
  • Arnold JR, Karamitsos TD, Bhamra-Ariza P, Francis JM, Searle N, Robson MD, Howells RK, Choudhury RP, Rimoldi OE, Camici PG, Banning AP, Neubauer S, Jerosch-Herold M, Selvanayagam JB. Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla. J Am Coll Cardiol. 2012 May 29;59(22):1954-64. doi: 10.1016/j.jacc.2012.01.055. PMID: 22624835
  • Arnold JR, Karamitsos TD, van Gaal WJ, Testa L, Francis JM, Bhamra-Ariza P, Ali A, Selvanayagam JB, Westaby S, Sayeed R, Jerosch-Herold M, Neubauer S, Banning AP. Residual ischemia after revascularization in multivessel coronary artery disease: insights from measurement of absolute myocardial blood flow using magnetic resonance imaging compared with angiographic assessment. Circ Cardiovasc Interv. 2013 Jun;6(3):237-45. doi: 10.1161/CIRCINTERVENTIONS.112.000064. Epub 2013 May 21. PMID: 23696598

Supervision

I have supervised six doctoral students as principal supervisor.

Teaching

My main teaching contribution is through the supervision of postgraduate students. I also contribute to teaching undergraduate and clinical students.

Qualifications

  • BMBCh MA DPhil MRCP
  • EACVI Level-3 CMR accreditation (2016-)
  • CCT in Cardiology (2016)
  • Fellow of the Higher Education Academy (2023)
  • Postgraduate Diploma degree in Health Economics for Health Professionals and Policymakers (2025)

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