People

Dr Karen Appiah

Epidemiologist Leicester Real World Evidence Unit Diabetes Research Centre

Profile

I have a background in medical physiology and joined the Leicester Real World Evidence Unit in October 2019. I also hold a Master of Science degree in Stroke Medicine from University College London and completed my PhD with the Department of Cardiovascular Sciences at the University of Leicester. My research interests includes epidemiology prevention and pathophysiology. I am passionate and proactive and committed to improving and transforming patient care using my analytical competencies.

Research

My research activities include analysing and promoting translational evidence for health and wellbeing whereby I evaluate disease prognosis and develop predictive modelling risk score tools of health outcomes. I work with many large patient and healthy population databases and datasets and use my findings to make recommendations in guiding healthcare practice and patient management. My main source of funding is from Nuffield Health a healthcare charity with whom we have an external collaborative relationship and I contribute to the data analysis of their projects.

Publications

(0) Appiah KO, Nath M, Manning L, Davison WJ, Mazzucco S, Li L, John FP, Rothwell PM, Panerai RB, Haunton VJ, Robinson TG. Increasing Blood Pressure Variability Predicts Poor Functional Outcome Following Acute Stroke. J Stroke Cerebrovasc Dis. 2021 Jan;30(1):105466. doi: 10.1016/j.jstrokecerebrovasdis.2020.105466. Epub 2020 Nov 13. PMID: 33197799.

Davison WJ, Appiah K, Robinson TG, McGurgan IJ, Rothwell PM, Potter JF. A calcium channel or angiotensin converting enzyme inhibitor/angiotensin receptor blocker regime to reduced blood pressure variability in acute ischaemic stroke (CAARBS): A feasibility trial. J Neurol Sci. 2020;413:116753. doi:10.1016/j.jns.2020.116753

Appiah KOB, Patel M, Panerai RB, et al. Increased blood pressure variability following acute stroke is associated with poor long-term outcomes: a systematic review. Blood pressure monitoring. 2019;24(2):67-73.

Appiah KO, Minhas JS, Robinson TG. Managing high blood pressure during acute ischemic stroke and intracerebral hemorrhage. Current Opinion in Neurology. 2018;31(1):8-13.

Banerjee, G., D. Wilson, G. Ambler, K. Osei-Bonsu Appiah, C. Shakeshaft, S. Lunawat, H. Cohen, T. Yousry, G. Y. H. Lip, K. W. Muir, M. M. Brown, R. Al-Shahi Salman, H. R. Jäger and D. J. Werring (2017). "Cognitive Impairment Before Intracerebral Hemorrhage Is Associated With Cerebral Amyloid Angiopathy." Stroke.

Appiah, K. O. B., et al. (2017). "Blood pressure variability: The methodological heterogeneity in quantifying the prognostic value in acute stroke." International Journal of Stroke 12 (5 Supplement 2): 11.

Supervision

Acute stroke; prognostic modelling; hip and knee replacement PROMs

Press and media

Acute stroke; prognostic modelling; hip and knee replacement PROMs

Activities

Referee for Journal of Diabetes Obesity and Metabolism ; NIHR ARC East Midlands Faculty Member

Awards

Milan May 2019

Conferences

Blood pressure variability: the methodological heterogeneity in quantifying the prognostic value in acute stroke; UK Stroke Forum Conference Liverpool November 2017

Increased blood pressure variability predicts poor short-term functional outcome; European Stroke Organisation Conference Gothenburg May 2018

Acceptability of Blood Pressure Variability Measurement Techniques Following Acute Ischaemic Stroke; European Stroke Organisation Conference Gothenburg May 2018

Observing the Natural History of Blood Pressure Variability following Acute Ischaemic Stroke and Transient Ischaemic Attack; Telford December 2018

Predicting long-term independence following stroke: added value of increased BPV assessed from enhanced casual BP; European Stroke Organisation Conference Milan May 2019

Increasing BPV from Day-Time ABPM Predicts Long Term Functional Outcome Following Acute Stroke; European Stroke Organisation Conference Milan May 2019

Increasing BPV measured from 24-Hour ABPM improves prediction of long-term functional outcome compared to enhanced casual BP; European Stroke Organisation Conference

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