Dr Dennis Bernieh

Dr Bernieh is an Early Career Researcher working at the van Geest MultiOmics Facility in the Division of Cardiovascular Sciences. His research interest involves the application of mass spectrometry-based omics approaches to understand how fundamental metabolic processes are altered in multimorbid cardiovascular disease. With a focus on how risk factors are shared across these chronic conditions (hypertension, diabetes, obesity and heart failure) leading to cardiovascular multimorbidity. He specialises in the identification of novel biological markers for diagnosis, prognosis, early risk stratification and precision medicine interventions.

Oct 2025 Wellcome Trust (£201,979, PI), Mechanistic investigation of maladaptive metabo-energetics remodelling in multimorbid cardiovascular disease

July 2023 MRC Impact Accelerator Account (£68,000, PI), Multiomics of energy metabolism remodelling in multimorbid CVD

Sept 2023 Future50, Institute of Precision Health, PhD Studentship, (£80,000)

Nov 2022 UKRI-MRC, Equip–World Class Lab Award, (£357,750, Co-I), Advance TQ-MS with an automated sample extractor for a multiuser interdisciplinary translational research facility

Sept 2022 Future100, Institute of Precision Health, PhD Studentship, (£120,000)

Sept 2019 Industry & Academia Exchange (IAX) Grant, (£36,500, Co-I)

July 2019 MRC CiC/LD3 Grant, (£90,000, Co-I)

Dec 2018 Leicester Precision Medicine Institute (LPMI) Grant (£30,000, Co-I)

1. Jenkins, S., Cross, A., Osman, H., Salim, F., Lane, D., Bernieh, D., Khunti, K. and Gupta, P., 2024. Effectiveness of biofeedback on blood pressure in patients with hypertension: systematic review and meta-analysis. J Hum Hypertens, 38(10), pp.719-727.
   
   
2. Nazareth, J., Adebayo, A., Fahad, M., Karim, H., Pan, D., Sze, S., Martin, C.A., Minhas, J.S., Bernieh, D., Osman, H. and Elverstone, P., 2024. Cardiovascular medication adherence testing in patients living with HIV: A single‐centre observational study. HIV Med, 25(12), pp.1330-1339.
   
   
3. Agarwal, A., Osman, H., Patel, P., Mathur, S.K., Bernieh, D. and Gupta, P., 2024. Systematic review of medication adherence in patients with hypertension in India. J Hypertens, 42(Suppl 1), p.e59.
   
   
4. Bernieh D, Larwood LA, Gill H, Lane D, Jones D, Gupta P. (2023) Development of a multianalyte mass spectrometry method for quantitation of antihypertensives in milk. J Hypertens. 41(Suppl 1): e288-9.
   
   
5. Osman H, Lane D, Bernieh D, Seidu S, Patel P, Khunti K, Brunskill NJ, Xu G, Gupta P. (2023). An innovative chemical adherence test demonstrates very high rates of non-adherence to oral cardio-metabolic medications. Kidney Int Rep. https://doi.org/10.1016/j.ekir.2023.09.033
   
   
6. Bernieh D, Lane D, Gill H, Jones D, Gupta P. (2023). Microsampling based mass spectrometry for quantification of angiotensin peptides in the renin angiotensin aldosterone system. J Hypertens, 41(Suppl 1):e110-1.
   
   
7. Bernieh D, Lane D, Rufus P, Osman H, Salim F, Alghamdi R, Jenkins S, Gill H, Ng L, Jones D, Gupta P. (2022). Development of a targeted proteomics assay for quantification of angiotensin peptides in the renin angiotensin aldosterone system. J Hypertens, 40(Suppl 1): e284.
   
   
8. Argyridou S, Davies MJ, Biddle GJH, Bernieh D, Suzuki T, Dawkins NP, Rowlands AV, Khunti K, Smith AC, Yates T. (2021). Evaluation of an 8-Week Vegan Diet on Plasma Trimethylamine-N-Oxide and Postchallenge Glucose in Adults with Dysglycemia or Obesity. J Nutr. doi: 10.1093/jn/nxab046. Epub ahead of print. PMID: 33784394.
   
   
9. Israr, M.Z., Bernieh, D., Salzano, A., Cassambai, S., Yazaki, Y., Heaney, L.M., Jones, D.J., Ng, L.L. and Suzuki, T., 2021. Association of gut-related metabolites with outcome in acute heart failure. Am Heart J. 234, pp.71-80.
   
   
10. Argyridou, S., Bernieh, D., Henson, J., Edwardson, C.L., Davies, M.J., Khunti, K., Suzuki, T. and Yates, T., 2020. Associations between physical activity and trimethylamine N-oxide in those at risk of type 2 diabetes. BMJ Open Diabetes Res Care, 8(2), p.e001359.
    
    
11. Israr, M.Z., Bernieh, D., Salzano, A., Yazaki, Y. and Suzuki, T., 2020. Matrix-assisted laser desorption ionisation (MALDI) mass spectrometry (MS): basics and clinical applications. Clin Chem Lab Med, 58(6), pp.883-896.
    
    
12. Yazaki, Y., Aizawa, K., Israr, M.Z., Negishi, K., Salzano, Cassambai, S. and Bernieh, D., 2020. Ethnic differences in association of outcomes with trimethylamine N‐oxide in acute heart failure patients. ESC Heart Fail. 7(5), pp.2373-2378.
    
    
13. Salzano, A., Israr, M.Z., Garcia, D.F., Middleton, L., Bernieh, D., Cassambai, S. and Page, K., 2020. Circulating cell-free DNA levels are associated with adverse outcomes in heart failure: testing liquid biopsy in heart failure. Eur J Prev Cardiol, p.2047487320912375.
    
    
14. Salzano, A., Cassambai, S., Yazaki, Y., Israr, M.Z., Bernieh, D., Wong, M. and Suzuki, T. (2020). The Gut Axis Involvement in Heart Failure: Focus on Trimethylamine N-oxide. Heart Fail Clin, 16(1), pp.23-31.
    
    
15. Cassambai, S., Salzano, A., Yazaki, Y., Bernieh, D., Wong, M., Israr, M. Z, Suzuki, T. (2019). Impact of acute choline loading on circulating trimethylamine N-oxide (TMAO) levels. Eur J Prev Cardiol. 26(17), pp.1899-1902.
    
    
16. Tanna, S., Alalaqi, A., Bernieh, D., and Lawson, G. (2018). VAMS coupled with HRMS as a simplified alternative to DBS analysis for TDM of cardiovascular drugs. Clin Mass Spectrom, 10, pp.1-8.
    
    
17. Bernieh, D., Lawson, G., and Tanna, S. (2017). Quantitative LC-HRMS determination of cardiovascular drugs, in dried blood spots, as an indicator of adherence to medication. J Pharm Biomed Anal, 142, pp.232 - 243.
    
    
18. Tanna, S., Bernieh, D., and Lawson, G. (2015). LC-HRMS analysis of dried blood spot samples for assessing adherence to cardiovascular medications. Journal of Bioanalysis & Biomedicine, 7(1) p001 – 005.

Dr Bernieh supervises projects on:

• Mass spectrometric techniques for biomarker discovery, validation and quantification
• Quantitative Proteomics
• Metabolomics
• Microsampling for point of care testing applications
• Mass spectrometric techniques for assessment of Medications Adherence and Therapeutic Drug Monitoring

PhD

Current PhD Student – Ammar Akram (IPH Future50 2023-2027, Second Supervisor)

Current PhD Student – Elliot Gyedu (IPH, Future100 2022-2026, Second Supervisor)

Dr Bernieh teaches on the following research modules in the School of Biological Sciences:

BSc (BS3101, BS3102, BS3201, BS0012)

MSc (BS4010)

• Member of the Scientific Committee (Life Science), 26^th International Mass Spectrometry Conference (IMSC) 2026
• Reviewer, Journal of Mass Spectrometry & Advances in the Clinical Lab (JMSACL).
• Member, European Society of Cardiology (ESC), Working Group on Cellular Biology of the Heart.
• Member, ESC Council on Basic Cardiovascular Science.
• Member, The British Mass Spectrometry Society, UK (BMSS).
• ECR representative, UoL BHF 4-year PhD Steering Committee.
• Fellow, Higher Education Academy

Dec 2024 – Wellcome Accelerator Award

June 2022 – European Society of Hypertension, Talal Zein Award

• Energy metabolism
• Biomarkers of cardiometabolic disease
• Precision Medicine
• Mass Spectrometry