Clareece Nevill

I am a Research Associate in the Biostatistics Research Group, where I spend half of my time as part of an NIHR Evidence Synthesis Group and the other half on my PhD. My field of interest is in evidence synthesis, primarily focusing on the following:

• Data visualisation
• Interactive applications
• Meta-analysis (including network, diagnostic, and living)

The research tab described in more detail my current research projects.

Evidence Synthesis Group @ Complex Reviews Synthesis Unit

I conduct and support various evidence synthesis projects that come through the ESG @ CRSU via the NIHR Evidence Synthesis Programme.

I also contribute to the development of the CRSU's suite of evidence synthesis web applications. As well as general upkeep and user improvements of the apps, I have been involved in development particular features:

• Network meta-regression
• Visualisation of network meta-analysis ranking
• Interactive assessment of future studies such that they influence meta-analyses

NIHR Doctoral Research Fellowship

I am currently pursuing a PhD under the NIHR Doctoral Research Fellowship programme. The current title of my PhD is 'Development and Evaluation of Synthesis Methods for Living Systematic Reviews including an Interactive Platform for Analysis, Updating and Dissemination: An Application to Electronic Cigarettes for Smoking Cessation'. The key aims of the PhD in the field of living systematic reviews (LSRs) are:

• Establish the evidence synthesis methodology, and reporting approaches used to communicate results, regarding LSRs
• Improve and evaluate methods for identifying optimal time-points for publishing LSR results and for informing the design of future research
• Improve the conduct of LSRs, tackling their continual updates and evolving evidence-base, and improve the accessibility and communication of LSR results and update to different user groups
• Assess the generalisability of tools in WP3, and address the practical challenges of publishing LSRs

Raval, P; Kulkarni, K; Johnson, N; Divall, P; Nevill, C; Sutton, A; Dias, J. Frequency and reporting of complications after Dupuytren’s contracture interventions: A systematic review and meta-analysis. Plastic and Reconstructive Surgery ():10.1097/PRS.0000000000011440, March 29, 2024. | DOI: 10.1097/PRS.0000000000011440 

Nicola Cooper, Evi Germeni, Suzanne C Freeman, Nishant Jaiswal, Clareece R Nevill, Alex J Sutton, Martin Taylor-Rowan, Terence J Quinn, New horizons in evidence synthesis for older adults, Age and Ageing, Volume 52, Issue 11, November 2023, afad211, https://doi.org/10.1093/ageing/afad211

Freeman, S.C., Saeedi, E., Ordóñez-Mena, J.M., Nevill, C.R. et al. Data visualisation approaches for component network meta-analysis: visualising the data structure. BMC Med Res Methodol23, 208 (2023). https://doi.org/10.1186/s12874-023-02026-z

Nevill CR, Cooper NJ, Sutton AJ. A multifaceted graphical display, including treatment ranking, was developed to aid interpretation of network meta-analysis. J Clin Epidemiol. 2023 May;157:83-91. doi: 10.1016/j.jclinepi.2023.02.016. Epub 2023 Mar 3. PMID: 36870376.

Hussein, H., Nevill, C.R., Meffen, A. et al. Double-counting of populations in evidence synthesis in public health: a call for awareness and future methodological development. BMC Public Health22, 1827 (2022). https://doi.org/10.1186/s12889-022-14213-6

Xin, Y., Nevill, C.R., Nevill, J. et al. Feasibility study for interactive reporting of network meta-analysis: experiences from the development of the MetaInsight COVID-19 app for stakeholder exploration, re-analysis and sensitivity analysis from living systematic reviews. BMC Med Res Methodol22, 26 (2022). https://doi.org/10.1186/s12874-022-01507-x

Quinn, T.J., Burton, J.K., Carter, B. et al. Following the science? Comparison of methodological and reporting quality of covid-19 and other research from the first wave of the pandemic. BMC Med19, 46 (2021). https://doi.org/10.1186/s12916-021-01920-x

Sze S, Pan D, Nevill CR, Gray LJ, Martin CA, Nazareth J, Minhas JS, Divall P, Khunti K, Abrams KR, Nellums LB, Pareek M. Ethnicity and clinical outcomes in COVID-19: A systematic review and meta-analysis. EClinicalMedicine. 2020 Dec;29:100630. doi: 10.1016/j.eclinm.2020.100630. Epub 2020 Nov 12. PMID: 33200120; PMCID: PMC7658622.

Freeman, S.C., Kerby, C.R., Patel, A. et al. Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA. BMC Med Res Methodol19, 81 (2019). https://doi.org/10.1186/s12874-019-0724-x