Sixty years of Genetics in Leicester

The Department of Genetics at the University of Leicester has a storied and illustrious history, marked by groundbreaking discoveries, pioneering research, and an enduring legacy in the field of genetic science. 

This year, the department, now known as Genetics, Genomics and Cancer Sciences proudly celebrates its 60th anniversary, a milestone that reflects six decades of transformative contributions to genetics. 

Since its inception, the department has been at the forefront of genetic research and education, making a profound impact on science and society alike.

A Landmark in Genetic Innovation: DNA Fingerprinting

One of the department's crowning achievements is undoubtedly the invention of DNA fingerprinting by Sir Alec Jeffreys in 1984. This revolutionary technique, discovered serendipitously, transformed forensic science and has since evolved into an indispensable tool in criminal investigations, paternity tests, and beyond. The significance of Jeffreys’ discovery cannot be overstated: it provided humanity with a means of uniquely identifying individuals based on their genetic makeup. From solving high-profile criminal cases to reuniting families separated by conflict, DNA fingerprinting has left an indelible mark on the world. Sir Alec’s contributions earned him global acclaim, cementing the University of Leicester’s reputation as a hub of genetic innovation.

Solving a Royal Mystery: The Richard III Identification

Fast forward to the 21st century, the department once again found itself in the global spotlight. In 2012, researchers played a pivotal role in the identification of the remains of King Richard III, discovered beneath a car park in Leicester. By comparing mitochondrial DNA from the skeletal remains to living descendants of Richard’s sister, the team confirmed the monarch’s identity. This remarkable achievement highlighted the power of genetics to unlock historical mysteries and brought together science, history, and archaeology in a way that captivated the public imagination. The Richard III project stands as a testament to the department’s interdisciplinary approach.

A Beacon for Microbial Research: The UK's First Phage Centre

Back in 1964, the department’s foundations stood firmly on microbial genetic research, reflecting the cutting-edge science of the time. That microbial thread has continued to the present day, exemplified by last year’s foundation of the UK’s first Phage Research Centre, a research initiative dedicated to understanding bacteriophages—viruses that infect bacteria. This area has gained renewed importance in recent years, as phages are potential solutions to the growing crisis of antibiotic resistance. By exploring the potential of these microscopic entities for therapy and many other biological interventions, Leicester’s phage scientists, led by Professor Martha Clokie, have positioned themselves at the cutting edge of an emerging field with significant implications for global health.

Breakthroughs in Behavioural Genetics

The department has also made unique contributions in the field of behavioural genetics. Professor Bambos Kyriacou and colleagues have conducted pioneering research into circadian rhythms, the biological processes that regulate sleep-wake cycles and other daily patterns. Their innovative work with fruit flies shed light on the genetic mechanisms underlying these rhythms, with implications for understanding human sleep disorders and other conditions. This research highlights the Department’s diverse expertise and its role in uncovering the genetic basis of complex behaviours.

Excellence in Cancer Research

In addition to its achievements in forensic and microbial genetics, the department boasts research strengths with direct medical relevance, exemplified by its Leicester Cancer Research Centre. This centre has earned a stellar reputation for its contributions to understanding the genetic underpinnings of cancer and developing targeted therapies. One of its key figures, Professor Dean Fennell, has been instrumental in advancing research into mesothelioma, a rare and aggressive cancer often linked to asbestos exposure. Under his leadership, the centre has pioneered clinical trials and explored innovative treatments, bringing hope to patients and their families. Dean’s work underscores the centre’s commitment to translating cutting-edge genetic research into real-world medical solutions.

 

A Future Built on Innovation and Collaboration

Today, the department continues to thrive as a hub of innovation, education, and collaboration. It remains deeply committed to addressing the pressing challenges of our time, from tackling genetic diseases to exploring the ethical implications of emerging biotechnologies. Its legacy is one of discovery, impact, and inspiration.

The anniversary will be marked today (Monday, December 16) in an event where guest speaker, Professor Julian Parkhill FRS from the University of Cambridge will review 60 years of genetic and genomic advances through the lens of microbial research, and Professor Bambos Kyriacou, the department’s longest serving member, will tell the history of Genetics in Leicester in his own inimitable style.

Genetics Professor Mark Jobling, who has been with the University for 32 of its 60 years, said: “The pioneering work taking place across the department since its very beginning continues today. We’re extremely proud of our achievements which are a true reflection of the innovative research being carried out by a dedicated team of people, working in a collegial and supportive atmosphere.”