Gene Expression: Molecular Basis and Medical Relevance

Module code: BS3010

This module follows the expression of protein-coding genes by looking at the environment of a gene in the nucleus, transcription, the processing of mRNA and production of multiple mRNA sequences from each gene, export of mRNA into the cytoplasm, proof-reading of mRNA, to the regulation by small RNA molecules. At all of these stages, we examine the mechanisms by which the level is controlled and fidelity maintained, and we address the origins of disease when these mechanisms fail. 

This module will give a thorough understanding of the molecular mechanisms of gene expression and its control, in mammals, to enable you to pursue independent study in this area. An emphasis will be put on the role of creative thought and rigorous tests of hypotheses in science and how to appraise published work and become independent thinkers in the planning and interpretation of experimental approaches to discovering how gene activity is controlled.