Publications

HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions, G. M. Williams, V. Paschalis, J. Ortega, F. W. Muskett, J. T. Hodgkinson, G. Li, J. W. R. Schwabe, R. S. Lahue. Proc. Natl. Acad. Sci. U.S.A., 2020, 117, 23597-23605.

Bifunctional HDAC Therapeutics: One Drug to Rule Them All? J. P. Smalley, S. M. Cowley, J. T. Hodgkinson, Molecules, 2020, 25, 4394.

PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes, J. P. Smalley, G. E. Adams, C. J. Millard, Y. Song, J. K. S. Norris,  J. W. R. Schwabe, S. M. Cowley, J. T. Hodgkinson, Chem. Commun., 2020, 56, 4476-4479.

Siderophore-Antibiotic Conjugate Design - New Drugs for Bad Bugs?, K. H. Negash, J. K. S. Norris, J. T. Hodgkinson, Molecules, 2019, 24, 3314.

The design and synthesis of an antibacterial phenothiazine–siderophore conjugate, A. Tarapdar, J. K. S. Norris, O. Sampson, G. Mukamolova, J. T. Hodgkinson, Beilstein J. Org. Chem., 2018, 14, 2646–2650.

Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of Pseudonocardia sp. natural products,  S.M. Geddis, T. Coroama, S. Forrest, J. T. Hodgkinson, M. Welch, D. R. Spring, Beilstein J. Org. Chem. 2018, 14, 2680-2688.

Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes, Y. R. Baker, J. T. Hodgkinson, B. I. Florea, E. Alza, W. R. J. D. Galloway, L. Grimm, S. M. Geddis, S. J. Walsh, H. S. Overkleeft, M. Welch, D. R. Spring, Chem. Sci. 2017, 8, 7403-7411

A new pseudomonas quinolone signal (PQS) binding partner: MexG, J. T. Hodgkinson, J. Gross, Y.R. Baker, D.R. Spring, M. Welch, Chem. Sci. 2016, 7, 2553-2562.

Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489, S. M. Geddis, L. Carro, J. T. Hodgkinson, D. R. Spring, Eur. J. Org. Chem. 2016, 5799-5802.

The synthesis of Quinolone Natural Products from Pseudonocardia sp. F. Salvaggio, J. T. Hodgkinson, L. Carro, S.M. Geddis, W.R.J.D. Galloway, M. Welch, D.R. Spring, Eur. J. Org. Chem. 2016, 434-437.

Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells, B. Morkunas, B. Gal, W. R. J. D. Galloway, J. T. Hodgkinson, B. M. Ibbeson, Y. S. Tan, M. Welch, D. R. Spring, Beilstein J. Org. Chem. 2016, 12, 1428-1433.

The Pseudomonas Quinolone Signal (PQS), T. Sams, Y. R. Baker, J. T. Hodgkinson, J. Gross, D. R. Spring, M. Welch, Israel J. Chem. 2016, 56, 282-294.

Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation, Z. Walsh, E. R. Janecek, J. T. Hodgkinson, J. Sedlmair, A. Koutsioubas, D. R. Spring, M. Welch, C. J. Hirschmugl, C. Toprakcioglu, J. R. Nitschke, M. Jones, O. A. Scherman, Proc. Natl. Acad. Sci. USA 2014, 111, 17743-17748.

Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy, A. Grossmann, S. Bartlett, M. Janecek, J. T. Hodgkinson, D. R. Spring, Angew. Chem. Int. Ed. 2014, 53, 13093-13097.

Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing, S. D. Bowden, N. Hale, J. C. S. Chung, J. T. Hodgkinson, D. R. Spring, M. Welch, Microbiol. 2013, 159, 2375-2385.

Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin, Y. R. Baker, W. R. J. D. Galloway, J. T. Hodgkinson, D. R. Spring, Molecules 2013, 18, 11783-11796.

Ligand Binding Kinetics of the Quorum sensing regulator PqsR, M Welch, J. T. Hodgkinson, J. Gross, D.R. Spring , T. Sams, Biochemistry, 2013, 52, 4433-4438.

Combating multi-drug resistant bacteria: current strategies for the discovery of novel antibacterials, K. M. G. O'Connell, J. T. Hodgkinson, H. F. Sore, M. Welch, G. P. C. Salmond, D. R. Spring, Angew. Chem. Int. Ed. 2013, 52, 10706-10733.

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics, B. Morkunas, W. R. J. D Galloway, M. Wright, B. M. Ibbeson, J. T. Hodgkinson, K. M. O'Connell, N. Bartolucci, M. Della Valle, M. Welch, D. R. Spring, Org. Biomol. Chem. 2012, 10, 8452-8464.

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria, W. R. J. D. Galloway, J. T. Hodgkinson, S. Bowden, M. Welch, D. R. Spring, Trends Microbiol. 2012, 20, 449-458.

Preparation of the quorum sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and structurally related analogues with biological activity using a microwave-assisted procedure, J. T. Hodgkinson, W. R. J. D. Galloway, M. Welch, D. R. Spring, Nature Protoc. 2012, 7, 1184-1192.

Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa, J. T. Hodgkinson, W. R. J. D. Galloway, M. Wright, I. K. Mati, R. L. Nicholson, M. Welch, D. R. Spring, Org. Biomol. Chem. 2012, 10, 6032-6044.

Robust routes for the synthesis of N-acylated-L-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity, J. T. Hodgkinson, W. R. J. D. Galloway, M. Casoli, H. Keane, X. Su, M. Welch, D. R. Spring, Tetrahedron Lett. 2011, 52, 3291-3294.

Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues, J. T. Hodgkinson, W. R. J. D. Galloway, S. Saraf, I. R. Baxendale, S. V. Ley, M. Ladlow, M. Welch, D. R. Spring, Org. Biomol. Chem. 2011, 9, 57-61.

Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways, W. R. J. D. Galloway, J. T. Hodgkinson, S. D. Bowden, M. Welch, D. R Spring, Chem. Rev. 2011, 11, 28-67.

Diversity-Oriented Synthesis of Macrocyclic Peptidomimetics, A. Isidro-Llobet, T. Murillo, P. Bello, A. Cilibrizzi, J. T. Hodgkinson, W. R. J. D. Galloway, A. Bender, M. Welch, D. R. Spring, Proc. Natl. Acad. Sci. USA 2011, 108, 6793-6798.

Novel and Efficient Copper-Catalysed Synthesis of Nitrogen-Linked Medium-Ring Biaryls, J. L. Kenwright, W. R. J. D. Galloway, D. T. Blackwell, A. Isidro-Llobet, J. Hodgkinson, L. Wortmann, S. D. Bowden, M. Welch, D. R. Spring, Chem. Eur. J. 2011, 17, 2981-2986.

2-Heptyl-4-Quinolone, a Precursor of the Pseudomonas Quinolone Signal Molecule, Modulates Swarming Motility in Pseudomonas aeruginosa, D. G. Ha, J. H. Merritt, T. H. Hampton, J. T. Hodgkinson, M. Janecek, D. R. Spring, M. Welch, G. A. O'Toole, J. Baceriol. 2011, 193, 6770-6780.

Controlling the contents of microdroplets by exploiting the permeability of PDMS, J. Shim, S. N. Patil, J. T. Hodgkinson, S. D. Bowden, D. R. Spring, M. Welch, W. T. S. Huck, F. Hollfelder, C. Abell, Lab Chip 2011, 11, 1132-1137.

Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule, J. T. Hodgkinson, S. D. Bowden, W. R. J. D. Galloway, D. R. Spring, M. Welch, J. Bacteriol. 2010, 192, 3833-3837.

Diversity-oriented synthesis of bicyclic and tricyclic alkaloids, M. Diaz Gavilan, W. R. J. D. Galloway, K. M. G. O'Connell, J. T. Hodgkinson, D. R. Spring, Chem. Commun. 2010, 46, 776-778.

Mastering the Chemical Language of Bacteria, W. R. J. D. Galloway, J. T. Hodgkinson, M. Welch, D. R. Spring, Chem. Biol. 2009, 16, 913-914.

2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator, L. Y. W. Lee, T. Hupfield, R. L. Nicholson, J. T. Hodgkinson, X. Su, G. L. Thomas, G. P. C. Salmond, M. Welch, D. R. Spring, Mol. Biosyst. 2008, 4, 505-507.

Synthesis of a Biotin Labeled Quorum Sensing Molecule; Towards a General Method for Target Identification, R. J. Spandl, R. L. Nicholson, D. M. Marsden, J. T. Hodgkinson, X. Su, G. L. Thomas, G. P. C. Salmond, M. Welch, D. R. Spring, Synlett 2008, 2122-2126.

Learning the Language of Bacteria, J. T. Hodgkinson, M. Welch, D. R. Spring, ACS Chem. Biol. 2007, 2, 715-717.